1XFA

Structure of NBD1 from murine CFTR- F508R mutant

Summary for 1XFA

Entry DOI	10.2210/pdb1xfa/pdb
Related	1XF9
Descriptor	Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	cystic fibrosis, abc transporters, atp, nucleotide-binding domain, transport protein
Biological source	Mus musculus (house mouse)
Cellular location	Early endosome membrane; Multi-pass membrane protein (By similarity): P26361
Total number of polymer chains	2
Total formula weight	64932.17
Authors	Thibodeau, P.H.,Brautigam, C.A.,Machius, M.,Thomas, P.J. (deposition date: 2004-09-14, release date: 2004-12-28, Last modification date: 2023-08-23)
Primary citation	Thibodeau, P.H.,Brautigam, C.A.,Machius, M.,Thomas, P.J. Side chain and backbone contributions of Phe508 to CFTR folding. Nat.Struct.Mol.Biol., 12:10-16, 2005 Cited by PubMed: 15619636 DOI: 10.1038/nsmb881 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation