4K8W
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AN ARM-SWAPPED DIMER OF THE S. PYOGENES PILIN SPECIFIC ASSEMBLY FACTOR SIPA
Descriptor:LepA, 1,2-ETHANEDIOL, ETHANOL
Authors:Young, P.G., Kang, H.J., Baker, E.N.
Deposit date:2013-04-19
Release date:2013-06-26
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:An arm-swapped dimer of the Streptococcus pyogenes pilin specific assembly factor SipA.
J.Struct.Biol., 183, 2013
1B12
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CRYSTAL STRUCTURE OF TYPE 1 SIGNAL PEPTIDASE FROM ESCHERICHIA COLI IN COMPLEX WITH A BETA-LACTAM INHIBITOR
Descriptor:SIGNAL PEPTIDASE I, prop-2-en-1-yl (2S)-2-[(2S,3R)-3-(acetyloxy)-1-oxobutan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylate, PHOSPHATE ION
Authors:Paetzel, M., Dalbey, R., Strynadka, N.C.J.
Deposit date:1999-11-24
Release date:1999-12-10
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor.
Nature, 396, 1998
3IIQ
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CRYSTALLOGRAPHIC ANALYSIS OF BACTERIAL SIGNAL PEPTIDASE IN TERNARY COMPLEX WITH ARYLOMYCIN A2 AND A BETA-SULTAM INHIBITOR
Descriptor:SIGNAL PEPTIDASE I, ARYLOMYCIN A2, 4-[(1,1-dioxido-1,2-thiazetidin-2-yl)carbonyl]morpholine, ...
Authors:Paetzel, M.
Deposit date:2009-08-03
Release date:2009-09-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A2 and a Beta-Sultam Inhibitor.
Biochemistry, 48, 2009
4N31
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STRUCTURE AND ACTIVITY OF STREPTOCOCCUS PYOGENES SIPA: A SIGNAL PEPTIDASE HOMOLOGUE ESSENTIAL FOR PILUS POLYMERISATION
Descriptor:SipA, PHOSPHATE ION, PHOSPHATIDYLETHANOLAMINE
Authors:Young, P.G., Proft, T., Baker, E.N.
Deposit date:2013-10-06
Release date:2014-08-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and activity of Streptococcus pyogenes SipA: a signal peptidase-like protein essential for pilus polymerisation.
Plos One, 9, 2014
1KN9
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CRYSTAL STRUCTURE OF A BACTERIAL SIGNAL PEPTIDASE APO-ENZYME, IMPLICATIONS FOR SIGNAL PEPTIDE BINDING AND THE SER-LYS DYAD MECHANISM.
Descriptor:Signal peptidase I
Authors:Paetzel, M., Dalbey, R.E., Strynadka, N.C.J.
Deposit date:2001-12-18
Release date:2002-01-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanism
J.Biol.Chem., 277, 2002
6B88
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E. COLI LEPB IN COMPLEX WITH GNE0775 ((4S,7S,10S)-10-((S)-4-AMINO-2-(2-(4-(TERT-BUTYL)PHENYL)-4-METHYLPYRIMIDINE-5-CARBOXAMIDO)-N-METHYLBUTANAMIDO)-16,26-BIS(2-AMINOETHOXY)-N-(2-IMINOETHYL)-7-METHYL-6,9-DIOXO-5,8-DIAZA-1,2(1,3)-DIBENZENACYCLODECAPHANE-4-CARBOXAMIDE)
Descriptor:Signal peptidase I, (8S,11S,14S)-14-{[(2S)-4-amino-2-{[2-(4-tert-butylphenyl)-4-methylpyrimidine-5-carbonyl]amino}butanoyl](methyl)amino}-3,18-bis(2-aminoethoxy)-N-[(2Z)-2-iminoethyl]-11-methyl-10,13-dioxo-9,12-diazatricyclo[13.3.1.1~2,6~]icosa-1(19),2(20),3,5,15,17-hexaene-8-carboxamide, PENTAETHYLENE GLYCOL
Authors:Murray, J.M., Rouge, L.
Deposit date:2017-10-05
Release date:2018-10-10
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.407 Å)
Cite:Optimized arylomycins are a new class of Gram-negative antibiotics.
Nature, 561, 2018
3S04
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI TYPE I SIGNAL PEPTIDASE IN COMPLEX WITH AN ARYLOMYCIN LIPOGLYCOPEPTIDE ANTIBIOTIC
Descriptor:Signal peptidase I, Glyco-Arylomycin, 14-methylhexadec-9-enoic acid, ...
Authors:Paetzel, M., Luo, C.
Deposit date:2011-05-13
Release date:2011-10-05
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase.
J.Am.Chem.Soc., 133, 2011
1T7D
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI TYPE I SIGNAL PEPTIDASE IN COMPLEX WITH A LIPOPEPTIDE INHIBITOR
Descriptor:SIGNAL PEPTIDASE I, ARYLOMYCIN A2, 10-METHYLUNDECANOIC ACID
Authors:Paetzel, M., Goodall, J.J., Kania, M., Dalbey, R.E., Page, M.G.P.
Deposit date:2004-05-09
Release date:2004-07-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide Based Inhibitor.
J.Biol.Chem., 279, 2004
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