3IIQ

Crystallographic analysis of bacterial signal peptidase in ternary complex with Arylomycin A2 and a beta-sultam inhibitor

Summary for 3IIQ

• Entry DOI: 10.2210/pdb3iiq/pdb
• Related: 1B12 1KN9 1T7D
• Related PRD ID: PRD_000117
• Descriptor: SIGNAL PEPTIDASE I, ARYLOMYCIN A2, 4-[(1,1-dioxido-1,2-thiazetidin-2-yl)carbonyl]morpholine, ... (8 entities in total)
• Functional Keywords: ser/lys dyad, lipopeptide, serine protease, biaryl bridge, morpholino beta-sultam, antibiotic, peptidase, hydrolase-antibiotic-inhibitor complex, hydrolase/antibiotic/inhibitor
• Biological source: ESCHERICHIA COLI; More
• Cellular location: Cell inner membrane; Multi-pass membrane protein: P00803
• Total number of polymer chains: 4
• Total formula weight: 59219.29

Authors

Paetzel, M. (deposition date: 2009-08-03, release date: 2009-09-01, Last modification date: 2023-09-06)

• Primary citation: Luo, C.,Roussel, P.,Dreier, J.,Page, M.G.,Paetzel, M.; Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A2 and a Beta-Sultam Inhibitor.; Biochemistry, 48:8976-, 2009; PubMed: 19655811; DOI: 10.1021/BI9009538

Experimental method

X-RAY DIFFRACTION (2 Å)