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Anthrax Toxin Lethal factor
Descriptor:	Lethal Factor precursor, SULFATE ION, ZINC ION
Authors:	Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
Deposit date:	2001-05-17
Release date:	2001-11-07
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal structure of the anthrax lethal factor. Nature, 414, 2001

1JKY

Crystal Structure of the Anthrax Lethal Factor (LF): Wild-type LF Complexed with the N-terminal Sequence of MAPKK2
Descriptor:	Lethal Factor, mitogen-activated protein kinase kinase 2
Authors:	Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
Deposit date:	2001-07-13
Release date:	2001-11-07
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (3.9 Å)
Cite:	Crystal structure of the anthrax lethal factor. Nature, 414, 2001

1PWP

Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155
Descriptor:	Lethal factor, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA, ZINC ION
Authors:	Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
Deposit date:	2003-07-02
Release date:	2004-01-13
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Identification of small molecule inhibitors of anthrax lethal factor. Nat.Struct.Mol.Biol., 11, 2004

1PWQ

Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a metal-chelating peptidyl small molecule inhibitor
Descriptor:	Lethal factor, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE, ZINC ION
Authors:	Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
Deposit date:	2003-07-02
Release date:	2004-01-13
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (3.52 Å)
Cite:	The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat.Struct.Mol.Biol., 11, 2004

1PWW

Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.
Descriptor:	LF20, Lethal factor, ZINC ION
Authors:	Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
Deposit date:	2003-07-02
Release date:	2004-01-27
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat.Struct.Mol.Biol., 11, 2004

1PWV

Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.
Descriptor:	LF20, Lethal factor
Authors:	Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
Deposit date:	2003-07-02
Release date:	2004-02-03
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (2.85 Å)
Cite:	The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat.Struct.Mol.Biol., 11, 2004

1PWU

Crystal Structure of Anthrax Lethal Factor complexed with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide), a known small molecule inhibitor of matrix metalloproteases.
Descriptor:	3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, Lethal factor, ZINC ION
Authors:	Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
Deposit date:	2003-07-02
Release date:	2004-02-03
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat.Struct.Mol.Biol., 11, 2004

1XFX

Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride
Descriptor:	CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:	Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:	2004-09-15
Release date:	2005-05-03
Last modified:	2017-12-20
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005

1XFZ

Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride
Descriptor:	CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:	Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:	2004-09-15
Release date:	2005-05-03
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (3.25 Å)
Cite:	Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005

1XFU

Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin
Descriptor:	CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:	Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:	2004-09-15
Release date:	2005-05-03
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (3.35 Å)
Cite:	Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005

1XFY

Crystal structure of anthrax edema factor (EF) in complex with calmodulin
Descriptor:	CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:	Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:	2004-09-15
Release date:	2005-05-03
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005

1XFW

Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP)
Descriptor:	ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, Calmodulin 2, ...
Authors:	Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:	2004-09-15
Release date:	2005-05-03
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (3.4 Å)
Cite:	Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005

1XFV

Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
Descriptor:	3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin 2, ...
Authors:	Shen, Q, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:	2004-09-15
Release date:	2005-05-03
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (3.35 Å)
Cite:	Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005

1Y0V

Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate
Descriptor:	CALCIUM ION, Calmodulin, Calmodulin-sensitive adenylate cyclase, ...
Authors:	Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.-J.
Deposit date:	2004-11-16
Release date:	2005-05-03
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (3.6 Å)
Cite:	Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor Embo J., 24, 2005

1YQY

Structure of B. Anthrax Lethal factor in complex with a hydroxamate inhibitor
Descriptor:	(2R)-2-{[(4-FLUORO-3-METHYLPHENYL)SULFONYL]AMINO}-N-HYDROXY-2-TETRAHYDRO-2H-PYRAN-4-YLACETAMIDE, Lethal factor, ZINC ION
Authors:	Shoop, W.L, Xiong, Y, Wiltsie, J, Woods, A, Guo, J, Pivnichny, J.V, Felcetto, T, Michael, B.F, Bansal, A.
Deposit date:	2005-02-02
Release date:	2005-05-31
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Anthrax lethal factor inhibition. Proc.Natl.Acad.Sci.Usa, 102, 2005

1ZXV

X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.
Descriptor:	(E)-3-(5((5-(4-CHLOROPHENYL)FURAN-2-YL)METHYLENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)PROPANOIC ACID, ZINC ION, lethal factor
Authors:	Wong, T.Y, Liddington, R.C.
Deposit date:	2005-06-08
Release date:	2005-07-05
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.67 Å)
Cite:	Efficient synthetic inhibitors of anthrax lethal factor. Proc.Natl.Acad.Sci.Usa, 102, 2005

3KWV

Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers
Descriptor:	CALCIUM ION, Lethal factor, Protective antigen PA-63
Authors:	Feld, G.K, Kintzer, A.F, Krantz, B.A.
Deposit date:	2009-12-01
Release date:	2010-11-10
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (3.101 Å)
Cite:	Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers. Nat.Struct.Mol.Biol., 17, 2010

2L0R

Conformational Dynamics of the Anthrax Lethal Factor Catalytic Center
Descriptor:	Lethal factor
Authors:	Dalkas, G.A, Chasapis, C.T, Gkazonis, P.V, Bentrop, D.A, Spyroulias, G.A.
Deposit date:	2010-07-15
Release date:	2010-12-22
Last modified:	2011-07-13
Method:	SOLUTION NMR
Cite:	Conformational dynamics of the anthrax lethal factor catalytic center. Biochemistry, 49, 2010

4DV8

Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule PT8421
Descriptor:	(2S)-6-[(4-fluorobenzyl)amino]-2-[(2R)-2-(4-fluorophenyl)-2-methoxyethyl]-N-hydroxyhexanamide, Lethal factor, MALONATE ION, ...
Authors:	Margosiak, S.A, Sankaran, B.
Deposit date:	2012-02-22
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.632 Å)
Cite:	Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain. Bioorg.Med.Chem.Lett., 22, 2012

4FXQ

Full-length Certhrax toxin from Bacillus cereus in complex with Inhibitor P6
Descriptor:	8-fluoro-2-(3-piperidin-1-ylpropanoyl)-1,3,4,5-tetrahydrobenzo[c][1,6]naphthyridin-6(2H)-one, CHLORIDE ION, Putative ADP-ribosyltransferase Certhrax, ...
Authors:	Visschedyk, D.D, Dimov, S, Kimber, M.S, Park, H.W, Merrill, A.R.
Deposit date:	2012-07-03
Release date:	2012-09-26
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.9599 Å)
Cite:	Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus. J.Biol.Chem., 287, 2012

4GF1

Crystal Structure of Certhrax
Descriptor:	Putative ADP-ribosyltransferase Certhrax, UNKNOWN ATOM OR ION
Authors:	Hong, B.S, Dimov, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Park, H, Structural Genomics Consortium (SGC)
Deposit date:	2012-08-02
Release date:	2012-09-26
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus. J.Biol.Chem., 287, 2012

4PKS

Anthrax toxin lethal factor with bound small molecule inhibitor 11
Descriptor:	1,2-ETHANEDIOL, GLYCEROL, Lethal factor, ...
Authors:	Maize, K.M, De la Mora, T, Finzel, B.C.
Deposit date:	2014-05-15
Release date:	2014-11-12
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014

4PKR

Anthrax toxin lethal factor with bound small molecule inhibitor 10
Descriptor:	CHLORIDE ION, GLYCEROL, Lethal factor, ...
Authors:	Maize, K.M, De la Mora, T, Finzel, B.C.
Deposit date:	2014-05-15
Release date:	2014-11-12
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014

4PKU

Anthrax toxin lethal factor with bound small molecule inhibitor 15
Descriptor:	Lethal factor, N~2~-(3-aminobenzyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
Authors:	Maize, K.M, De la Mora, T, Finzel, B.C.
Deposit date:	2014-05-15
Release date:	2014-11-12
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014

4PKW

Anthrax toxin lethal factor with bound small molecule inhibitor GM6001
Descriptor:	1,2-ETHANEDIOL, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, GLYCEROL, ...
Authors:	Maize, K.M, De la Mora, T, Finzel, B.C.
Deposit date:	2014-05-15
Release date:	2014-11-12
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014

12 3 >

Total results:	70
Displayed results:	25
Sorted by:	Release date (from oldest)
Query:	PF07737