2XSA
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OGOGA APOSTRUCTURE
Descriptor:HYALURONOGLUCOSAMINIDASE, CHLORIDE ION
Authors:Schuttelkopf, A.W., van Aalten, D.M.F.
Deposit date:2010-09-27
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human Oga Binds Substrates in a Conserved Peptide Recognition Groove.
Biochem.J., 432, 2010
2XSB
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OGOGA PUGNAC COMPLEX
Descriptor:HYALURONOGLUCOSAMINIDASE, 2-ACETAMIDO-2-DEOXY-D-GLUCONO-1,5-LACTONE, CHLORIDE ION
Authors:Schuttelkopf, A.W., van Aalten, D.M.F.
Deposit date:2010-09-27
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Human Oga Binds Substrates in a Conserved Peptide Recognition Groove.
Biochem.J., 432, 2010
5DIY
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THERMOBACULUM TERRENUM O-GLCNAC HYDROLASE MUTANT - D120N
Descriptor:TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Hyaluronidase, N-ACETYL-D-GLUCOSAMINE
Authors:Ostrowski, A., Gundogdu, M., Ferenbach, A.T., Lebedev, A., van Aalten, D.M.F.
Deposit date:2015-09-01
Release date:2015-10-28
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum.
J.Biol.Chem., 290, 2015
5M7R
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STRUCTURE OF HUMAN O-GLCNAC HYDROLASE
Descriptor:Protein O-GlcNAcase
Authors:Roth, C., Chan, S., Offen, W.A., Hemsworth, G.R., Willems, L.I., King, D., Varghese, V., Britton, R., Vocadlo, D.J., Davies, G.J.
Deposit date:2016-10-28
Release date:2017-03-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and functional insight into human O-GlcNAcase.
Nat. Chem. Biol., 13, 2017
5M7S
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STRUCTURE OF HUMAN O-GLCNAC HYDROLASE WITH BOUND TRANSITION STATE ANALOG THIAMETG
Descriptor:Protein O-GlcNAcase, (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL
Authors:Roth, C., Chan, S., Offen, W.A., Hemsworth, G.R., Willems, L.I., King, D., Varghese, V., Britton, R., Vocadlo, D.J., Davies, G.J.
Deposit date:2016-10-28
Release date:2017-03-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and functional insight into human O-GlcNAcase.
Nat. Chem. Biol., 13, 2017
5M7T
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STRUCTURE OF HUMAN O-GLCNAC HYDROLASE WITH PUGNAC TYPE INHIBITOR
Descriptor:Protein O-GlcNAcase, (5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE
Authors:Roth, C., Chan, S., Offen, W.A., Hemsworth, G.R., Willems, L.I., King, D., Varghese, V., Britton, R., Vocadlo, D.J., Davies, G.J.
Deposit date:2016-10-28
Release date:2017-03-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional insight into human O-GlcNAcase.
Nat. Chem. Biol., 13, 2017
5M7U
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STRUCTURE OF HUMAN O-GLCNAC HYDROLASE WITH NEW IMINOCYCLITOL TYPE INHIBITOR
Descriptor:Protein O-GlcNAcase, 2-[(2~{R},3~{S},4~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)-1-[3-[3-(trifluoromethyl)phenyl]propyl]pyrrolidin-2-yl]-~{N}-methyl-ethanamide
Authors:Roth, C., Chan, S., Offen, W.A., Hemsworth, G.R., Willems, L.I., King, D., Varghese, V., Britton, R., Vocadlo, D.J., Davies, G.J.
Deposit date:2016-10-28
Release date:2017-03-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional insight into human O-GlcNAcase.
Nat. Chem. Biol., 13, 2017
5TKE
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CRYSTAL STRUCTURE OF EUKARYOTIC HYDROLASE
Descriptor:O-GlcNAcase: chimera construct
Authors:Li, B., Jiang, J.
Deposit date:2016-10-06
Release date:2017-03-15
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.481 Å)
Cite:Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode.
Nat. Struct. Mol. Biol., 24, 2017
5UHK
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CRYSTAL STRUCTURE OF THE CORE CATALYTIC DOMAIN OF HUMAN O-GLCNACASE
Descriptor:O-GlcNAcase TIM-barrel domain, O-GlcNAcase stalk domain, GLYCEROL
Authors:Klein, D.J., Elsen, N.L.
Deposit date:2017-01-11
Release date:2017-03-29
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Crystal structure of the core catalytic domain of human O-GlcNAcase and molecular basis of activity and inhibition
To Be Published
5UHL
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CRYSTAL STRUCTURE OF THE CORE CATALYTIC DOMAIN OF HUMAN O-GLCNACASE COMPLEXED WITH THIAMET G
Descriptor:O-GlcNAcase TIM-barrel domain, O-GlcNAcase stalk domain, (2Z,3aR,5R,6S,7R,7aR)-2-(ethylimino)-5-(hydroxymethyl)hexahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
Authors:Klein, D.J., Elsen, N.L.
Deposit date:2017-01-11
Release date:2017-03-29
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Crystal structure of the core catalytic domain of human O-GlcNAcase and molecular basis of activity and inhibition
To Be Published
5UHO
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CRYSTAL STRUCTURE OF THE CORE CATALYTIC DOMAIN OF HUMAN O-GLCNACASE COMPLEXED WITH PUGNAC
Descriptor:O-GlcNAcase TIM-barrel domain, O-GlcNAcase stalk domain, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE
Authors:Klein, D.J., Elsen, N.L.
Deposit date:2017-01-11
Release date:2017-03-29
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Crystal structure of the core catalytic domain of human O-GlcNAcase and molecular basis of activity and inhibition
To Be Published
5UHP
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CRYSTAL STRUCTURE OF THE CORE CATALYTIC DOMAIN OF HUMAN O-GLCNACASE
Descriptor:O-GlcNAcase TIM-barrel domain, O-GlcNAcase stalk domain, GLYCEROL
Authors:Klein, D.J., Elsen, N.L.
Deposit date:2017-01-11
Release date:2017-03-29
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Crystal structure of the core catalytic domain of human O-GlcNAcase and molecular basis of activity and inhibition
To Be Published
5UN8
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CRYSTAL STRUCTURE OF HUMAN O-GLCNACASE IN COMPLEX WITH GLYCOPEPTIDE P53
Descriptor:Protein O-GlcNAcase, P53 peptide, N-ACETYL-D-GLUCOSAMINE
Authors:Li, B., Jiang, J.
Deposit date:2017-01-30
Release date:2017-03-15
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode.
Nat. Struct. Mol. Biol., 24, 2017
5UN9
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THE CRYSTAL STRUCTURE OF HUMAN O-GLCNACASE IN COMPLEX WITH THIAMET-G
Descriptor:Protein O-GlcNAcase, (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL
Authors:Li, B., Jiang, J.
Deposit date:2017-01-30
Release date:2017-03-15
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode.
Nat. Struct. Mol. Biol., 24, 2017
5VVO
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STRUCTURAL INVESTIGATIONS OF THE SUBSTRATE SPECIFICITY OF HUMAN O-GLCNACASE
Descriptor:Protein O-GlcNAcase
Authors:Li, B., Jiang, J., Li, H., Hu, C.-W.
Deposit date:2017-05-19
Release date:2017-09-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase.
Nat Commun, 8, 2017
5VVT
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STRUCTURAL INVESTIGATIONS OF THE SUBSTRATE SPECIFICITY OF HUMAN O-GLCNACASE
Descriptor:Protein O-GlcNAcase, ELK1 peptide, N-ACETYL-D-GLUCOSAMINE
Authors:Li, B., Jiang, J., Li, H., Hu, C.-W.
Deposit date:2017-05-20
Release date:2017-09-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase.
Nat Commun, 8, 2017
5VVU
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STRUCTURAL INVESTIGATIONS OF THE SUBSTRATE SPECIFICITY OF HUMAN O-GLCNACASE
Descriptor:Protein O-GlcNAcase, TAB1 peptide, N-ACETYL-D-GLUCOSAMINE
Authors:Li, B., Jiang, J., Li, H., Hu, C.-W.
Deposit date:2017-05-20
Release date:2017-09-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase.
Nat Commun, 8, 2017
5VVV
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STRUCTURAL INVESTIGATIONS OF THE SUBSTRATE SPECIFICITY OF HUMAN O-GLCNACASE
Descriptor:Protein O-GlcNAcase, a-crystallin B, N-ACETYL-D-GLUCOSAMINE
Authors:Li, B., Jiang, J., Li, H., Hu, C.-W.
Deposit date:2017-05-20
Release date:2017-09-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase.
Nat Commun, 8, 2017
5VVX
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STRUCTURAL INVESTIGATIONS OF THE SUBSTRATE SPECIFICITY OF HUMAN O-GLCNACASE
Descriptor:Protein O-GlcNAcase, Lamin B1, N-ACETYL-D-GLUCOSAMINE
Authors:Li, B., Jiang, J., Li, H., Hu, C.-W.
Deposit date:2017-05-21
Release date:2017-09-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase.
Nat Commun, 8, 2017
2CBI
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STRUCTURE OF THE CLOSTRIDIUM PERFRINGENS NAGJ FAMILY 84 GLYCOSIDE HYDROLASE, A HOMOLOGUE OF HUMAN O-GLCNACASE
Descriptor:HYALURONIDASE, SULFATE ION, CHLORIDE ION, ...
Authors:Rao, F.V., Dorfmueller, H.C., Villa, F., Allwood, M., Eggleston, I.M., van Aalten, D.M.F.
Deposit date:2006-01-04
Release date:2006-02-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.
EMBO J., 25, 2006
2CBJ
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STRUCTURE OF THE CLOSTRIDIUM PERFRINGENS NAGJ FAMILY 84 GLYCOSIDE HYDROLASE, A HOMOLOGUE OF HUMAN O-GLCNACASE IN COMPLEX WITH PUGNAC
Descriptor:HYALURONIDASE, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, CHLORIDE ION
Authors:Rao, F.V., Dorfmueller, H.C., Villa, F., Allwood, M., Eggleston, I.M., van Aalten, D.M.F.
Deposit date:2006-01-05
Release date:2006-02-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.
EMBO J., 25, 2006
2CHN
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BACTEROIDES THETAIOTAOMICRON HEXOSAMINIDASE WITH O-GLCNACASE ACTIVITY- NAG-THIAZOLINE COMPLEX
Descriptor:GLUCOSAMINIDASE, CALCIUM ION, 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, ...
Authors:Dennis, R.J., Taylor, E.J., Macauley, M.S., Stubbs, K.A., Turkenburg, J.P., Hart, S.J., Black, G.N., Vocadlo, D.J., Davies, G.J.
Deposit date:2006-03-15
Release date:2006-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and Mechanism of a Bacterial B-Glucosaminidase Having O-Glcnacase Activity
Nat.Struct.Mol.Biol., 13, 2006
2CHO
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BACTEROIDES THETAIOTAOMICRON HEXOSAMINIDASE WITH O-GLCNACASE ACTIVITY
Descriptor:GLUCOSAMINIDASE, CALCIUM ION, ACETATE ION, ...
Authors:Dennis, R.J., Taylor, E.J., Macauley, M.S., Stubbs, K.A., Turkenburg, J.P., Hart, S.J., Black, G.N., Vocadlo, D.J., Davies, G.J.
Deposit date:2006-03-16
Release date:2006-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and Mechanism of a Bacterial B-Glucosaminidase Having O-Glcnacase Activity
Nat.Struct.Mol.Biol., 13, 2006
2J47
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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH A IMIDAZOLE-PUGNAC HYBRID INHIBITOR
Descriptor:GLUCOSAMINIDASE, (5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE, GLYCEROL
Authors:Dennis, R.J., Davies, G.J.
Deposit date:2006-08-25
Release date:2006-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Inhibition of O-Glcnacase by a Gluco-Configured Nagstatin and a Pugnac-Imidazole Hybrid Inhibitor
Chem. Commun., 42, 2006
2J4G
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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH N-BUTYL- THIAZOLINE INHIBITOR
Descriptor:HYALURONOGLUCOSAMINIDASE, (3AR,5R,6S,7R,7AR)-5-(HYDROXYMETHYL)-2-PROPYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL, ACETATE ION, ...
Authors:Dennis, R.J., Davies, G.J.
Deposit date:2006-08-31
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Analysis of Pugnac and Nag-Thiazoline as Transition State Analogues for Human O-Glcnacase: Mechanistic and Structural Insights Into Inhibitor Selectivity and Transition State Poise.
J.Am.Chem.Soc., 129, 2007
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