5UN9

The crystal structure of human O-GlcNAcase in complex with Thiamet-G

Summary for 5UN9

• Entry DOI: 10.2210/pdb5un9/pdb
• Related: 5UN8
• Descriptor: Protein O-GlcNAcase, (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL (3 entities in total)
• Functional Keywords: human o-glcnacase, thiemat-g, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 3: Nucleus . Isoform 1: Cytoplasm : O60502
• Total number of polymer chains: 2
• Total formula weight: 116143.73

Authors

Li, B.,Jiang, J. (deposition date: 2017-01-30, release date: 2017-03-15, Last modification date: 2023-10-04)

• Primary citation: Li, B.,Li, H.,Lu, L.,Jiang, J.; Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode.; Nat. Struct. Mol. Biol., 24:362-369, 2017; PubMed: 28319083; DOI: 10.1038/nsmb.3390

Experimental method

X-RAY DIFFRACTION (2.5 Å)