8P0L

Crystal structure of human O-GlcNAcase in complex with an S-linked CKII peptide

Summary for 8P0L

Entry DOI	10.2210/pdb8p0l/pdb
Descriptor	Protein O-GlcNAcase, CYSTEINE, SERINE, ... (5 entities in total)
Functional Keywords	carbohydrate, s-glcnac, gh84, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	206489.27
Authors	Males, A.,Davies, G.J.,Calvelo, M.,Alteen, M.G.,Vocadlo, D.J.,Rovira, C. (deposition date: 2023-05-10, release date: 2023-11-29)
Primary citation	Calvelo, M.,Males, A.,Alteen, M.G.,Willems, L.I.,Vocadlo, D.J.,Davies, G.J.,Rovira, C. Human O -GlcNAcase Uses a Preactivated Boat-skew Substrate Conformation for Catalysis. Evidence from X-ray Crystallography and QM/MM Metadynamics. Acs Catalysis, 13:13672-13678, 2023 Cited by PubMed: 37969138 DOI: 10.1021/acscatal.3c02378 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation