5UHL

Crystal structure of the core catalytic domain of human O-GlcNAcase complexed with Thiamet G

Summary for 5UHL

• Entry DOI: 10.2210/pdb5uhl/pdb
• Related: 5UHK 5UHO 5UHp
• Descriptor: O-GlcNAcase TIM-barrel domain, O-GlcNAcase stalk domain, (2Z,3aR,5R,6S,7R,7aR)-2-(ethylimino)-5-(hydroxymethyl)hexahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol, ... (4 entities in total)
• Functional Keywords: hydrolase, o-glcnacase, gh84, enzyme, thiamet g
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 3: Nucleus . Isoform 1: Cytoplasm : O60502 O60502
• Total number of polymer chains: 4
• Total formula weight: 118044.43

Authors

Klein, D.J.,Elsen, N.L. (deposition date: 2017-01-11, release date: 2017-03-29, Last modification date: 2024-03-06)

• Primary citation: Elsen, N.L.,Patel, S.B.,Ford, R.E.,Hall, D.L.,Hess, F.,Kandula, H.,Kornienko, M.,Lumb, K.J.,Reid, J.,Selnick, H.,Shipman, J.M.,Sharma, S.,Soisson, S.M.,Klein, D.J.; Crystal structure of the core catalytic domain of human O-GlcNAcase and molecular basis of activity and inhibition; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.14 Å)