5UHL
Crystal structure of the core catalytic domain of human O-GlcNAcase complexed with Thiamet G
Summary for 5UHL
Entry DOI | 10.2210/pdb5uhl/pdb |
Related | 5UHK 5UHO 5UHp |
Descriptor | O-GlcNAcase TIM-barrel domain, O-GlcNAcase stalk domain, (2Z,3aR,5R,6S,7R,7aR)-2-(ethylimino)-5-(hydroxymethyl)hexahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol, ... (4 entities in total) |
Functional Keywords | hydrolase, o-glcnacase, gh84, enzyme, thiamet g |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform 3: Nucleus . Isoform 1: Cytoplasm : O60502 O60502 |
Total number of polymer chains | 4 |
Total formula weight | 118044.43 |
Authors | Klein, D.J.,Elsen, N.L. (deposition date: 2017-01-11, release date: 2017-03-29, Last modification date: 2024-03-06) |
Primary citation | Elsen, N.L.,Patel, S.B.,Ford, R.E.,Hall, D.L.,Hess, F.,Kandula, H.,Kornienko, M.,Lumb, K.J.,Reid, J.,Selnick, H.,Shipman, J.M.,Sharma, S.,Soisson, S.M.,Klein, D.J. Crystal structure of the core catalytic domain of human O-GlcNAcase and molecular basis of activity and inhibition To Be Published, |
Experimental method | X-RAY DIFFRACTION (3.14 Å) |
Structure validation
Download full validation report