5UHL
Crystal structure of the core catalytic domain of human O-GlcNAcase complexed with Thiamet G
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 8BJ A 501 |
| Chain | Residue |
| A | GLY67 |
| A | VAL254 |
| A | TRP278 |
| A | ASN280 |
| A | ASP285 |
| A | ASN313 |
| A | PHE68 |
| A | TYR69 |
| A | LYS98 |
| A | ASP174 |
| A | ASP175 |
| A | CYS215 |
| A | TYR219 |
| A | THR250 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue 8BJ C 501 |
| Chain | Residue |
| C | GLY67 |
| C | PHE68 |
| C | TYR69 |
| C | LYS98 |
| C | ASP174 |
| C | ASP175 |
| C | CYS215 |
| C | TYR219 |
| C | THR250 |
| C | VAL254 |
| C | TRP278 |
| C | ASN280 |
| C | ASP285 |
| C | TYR286 |
| C | ASN313 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 552 |
| Details | Domain: {"description":"GH84","evidences":[{"source":"PROSITE-ProRule","id":"PRU01353","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01353","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16533067","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28939839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VVT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
