PDB: 10 resultsInfo pagesStatus searchChemie searchBIRD

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6NY0	Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a bisbenzimidazole inhibitor Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-(4-{3-[4-(6-carboxy-1H-benzimidazol-2-yl)phenoxy]-2-hydroxypropoxy}phenyl)-1H-benzimidazole-5-carboxylic acid, Dihydrofolate reductase type 2, ... Authors: Yachnin, B.J, Berghuis, A.M. Deposit date: 2019-02-10 Release date: 2019-05-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues. Acs Omega, 4, 2019
6NXZ	Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a bisbenzimidazole inhibitor Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-[4-[(2~{R})-4-[4-(6-carboxy-1~{H}-benzimidazol-2-yl)phenoxy]-2-oxidanyl-butoxy]phenyl]-1~{H}-benzimidazole-5-carboxylic acid, Dihydrofolate reductase type 2, ... Authors: Yachnin, B.J, Berghuis, A.M. Deposit date: 2019-02-10 Release date: 2019-05-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues. Acs Omega, 4, 2019
3SFM	Novel crystallization conditions for tandem variant R67 DHFR yields wild-type crystal structure Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2 Authors: Yachnin, B.J, Berghuis, A.M. Deposit date: 2011-06-13 Release date: 2011-11-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure. Acta Crystallogr.,Sect.F, 67, 2011
2RK1	DHFR R67 Complexed with NADP and dihydrofolate Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, DIHYDROFOLIC ACID, Dihydrofolate reductase type 2, ... Authors: Krahn, J.M, London, R.E. Deposit date: 2007-10-16 Release date: 2008-06-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Crystal structure of a type II dihydrofolate reductase catalytic ternary complex. Biochemistry, 46, 2007
2RK2	DHFR R-67 complexed with NADP Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Krahn, J.M, London, R.E. Deposit date: 2007-10-16 Release date: 2008-06-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of a type II dihydrofolate reductase catalytic ternary complex. Biochemistry, 46, 2007
2RH2	High Resolution DHFR R-67 Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2 Authors: Krahn, J.M, London, R.E. Deposit date: 2007-10-05 Release date: 2008-06-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (0.96 Å) Cite: Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex Biochemistry, 46, 2007
2P4T	Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode Descriptor: Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Divya, N, Grifith, E, Narayana, N. Deposit date: 2007-03-13 Release date: 2007-06-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode. Protein Sci., 16, 2007
2GQV	High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the D2-symmetric active site Descriptor: Dihydrofolate reductase type 2 Authors: Narayana, N. Deposit date: 2006-04-22 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.1 Å) Cite: High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the D(2)-symmetric active site. Acta Crystallogr.,Sect.D, 62, 2006
1VIF	STRUCTURE OF DIHYDROFOLATE REDUCTASE Descriptor: DIHYDROFOLATE REDUCTASE, FOLIC ACID Authors: Narayana, N, Matthews, D.A, Howell, E.E, Xuong, N.-H. Deposit date: 1996-10-03 Release date: 1997-10-22 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site. Nat.Struct.Biol., 2, 1995
1VIE	STRUCTURE OF DIHYDROFOLATE REDUCTASE Descriptor: DIHYDROFOLATE REDUCTASE Authors: Narayana, N, Matthews, D.A, Howell, E.E, Xuong, N.-H. Deposit date: 1996-10-03 Release date: 1997-10-22 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site. Nat.Struct.Biol., 2, 1995