Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5WYI
DownloadVisualize
BU of 5wyi by Molmil
The Yaf9 YEATS domain Recognizing H3K122suc Peptide
Descriptor: (2S)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid, ILE-MET-PRO-LYS-ASP-ILE-GLN-LEU, SUCCINIC ACID, ...
Authors:Wang, Y, Hao, Q.
Deposit date:2017-01-13
Release date:2018-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Yaf9 YEATS domain Recognizing H3K122suc Peptide
To Be Published
6MIL
DownloadVisualize
BU of 6mil by Molmil
Crystal structure of AF9 YEATS domain in complex with histone H3K9bu
Descriptor: DI(HYDROXYETHYL)ETHER, Histone H3K9bu, MALONATE ION, ...
Authors:Vann, K.R, Klein, B.J, Kutateladze, T.G.
Deposit date:2018-09-19
Release date:2018-11-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain.
Nat Commun, 9, 2018
5J9S
DownloadVisualize
BU of 5j9s by Molmil
ENL YEATS in complex with histone H3 acetylation at K27
Descriptor: H3K27ac peptide from Histone H3.1, Protein ENL, SULFATE ION
Authors:Li, Y, Li, H.
Deposit date:2016-04-11
Release date:2017-03-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia
Nature, 543, 2017
4TMP
DownloadVisualize
BU of 4tmp by Molmil
Crystal structure of AF9 YEATS bound to H3K9ac peptide
Descriptor: 1,2-ETHANEDIOL, ALA-ARG-THR-LYS-GLN-THR-ALA-ARG-ALY-SER-THR, Protein AF-9
Authors:Li, H, Li, Y, Wang, H, Ren, Y.
Deposit date:2014-06-02
Release date:2014-11-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation.
Cell, 159, 2014
3FK3
DownloadVisualize
BU of 3fk3 by Molmil
Structure of the Yeats Domain, Yaf9
Descriptor: Protein AF-9 homolog
Authors:Wang, A.Y, Schulze, J.M, Skordalakes, E, Berger, J.M, Rine, J, Kobor, M.S.
Deposit date:2008-12-15
Release date:2009-10-27
Last modified:2021-03-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation
Proc.Natl.Acad.Sci.USA, 106, 2009
8DKB
DownloadVisualize
BU of 8dkb by Molmil
Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b
Descriptor: N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide, YEATS domain-containing protein 4
Authors:Dias, J.M, Byrnes, L.J, Varghese, A.H.
Deposit date:2022-07-05
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
J.Med.Chem., 66, 2023
5D7E
DownloadVisualize
BU of 5d7e by Molmil
Crystal structure of Taf14 YEATS domain in complex with H3K9ac
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, H3K9ac, ...
Authors:Andrews, F.H, Shanle, E.K, Strahl, B.D, Kutateladze, T.G.
Deposit date:2015-08-13
Release date:2015-09-23
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response.
Genes Dev., 29, 2015
7B0T
DownloadVisualize
BU of 7b0t by Molmil
Crystal structure of MLLT1 YEATS domain T3 mutant in complex with benzimidazole-amide based compound 1
Descriptor: 1,2-ETHANEDIOL, 3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide, Protein ENL
Authors:Ni, X, Chaikuad, A, Brennan, P.E, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2020-11-21
Release date:2021-02-17
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants.
Acs Chem.Biol., 16, 2021
7B10
DownloadVisualize
BU of 7b10 by Molmil
Crystal structure of MLLT1 YEATS domain T1 mutant in complex with benzimidazole-amide based compound 1
Descriptor: 1,2-ETHANEDIOL, 3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide, IODIDE ION, ...
Authors:Chaikuad, A, Ni, X, Brennan, P.E, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2020-11-23
Release date:2021-02-17
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants.
Acs Chem.Biol., 16, 2021
5VNB
DownloadVisualize
BU of 5vnb by Molmil
YEATS in complex with histone H3
Descriptor: 1,2-ETHANEDIOL, H3K23acK27ac peptide, SULFATE ION, ...
Authors:Cho, H.J, Cierpicki, T.
Deposit date:2017-04-29
Release date:2018-09-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode.
ACS Chem. Biol., 13, 2018
7E74
DownloadVisualize
BU of 7e74 by Molmil
Crystal structure of ENL YEATS domain T3 mutant in complex with histone H3 acetylation at K27
Descriptor: ALA-ALA-ARG-ALY, Protein ENL
Authors:Li, Y, Li, H.
Deposit date:2021-02-25
Release date:2021-07-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Mol.Cell, 82, 2022
7E7A
DownloadVisualize
BU of 7e7a by Molmil
Crystal structure of apo ENL YEATS domain T3 mutant
Descriptor: Protein ENL
Authors:Li, Y, Li, H.
Deposit date:2021-02-25
Release date:2021-07-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Crystal structure of ENL YEATS domain T1 mutant in complex with histone H3 acetylation at K27
To Be Published
5VNA
DownloadVisualize
BU of 5vna by Molmil
Crystal structure of human YEATS domain
Descriptor: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, SULFATE ION, ...
Authors:Cho, H.J, Cierpicki, T.
Deposit date:2017-04-29
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode.
ACS Chem. Biol., 13, 2018
3QRL
DownloadVisualize
BU of 3qrl by Molmil
Crystal Structure of the Taf14 YEATS domain
Descriptor: TRIETHYLENE GLYCOL, Transcription initiation factor TFIID subunit 14
Authors:Simpson, P.J, Warren, A.J.
Deposit date:2011-02-18
Release date:2012-02-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the Taf14 YEATS domain
To be Published
3RLS
DownloadVisualize
BU of 3rls by Molmil
Crystal structure of yeast AF-9 homolog protein Yaf9
Descriptor: Protein AF-9 homolog
Authors:Chen, S.D, Wu, L.J, Liu, Y.F.
Deposit date:2011-04-20
Release date:2011-05-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of yeast AF-9 homolog protein yaf9
To be Published
2L7E
DownloadVisualize
BU of 2l7e by Molmil
The structure of a domain from yeast
Descriptor: Transcription initiation factor TFIID subunit 14
Authors:Zhang, W, Zhang, J, Tu, X.
Deposit date:2010-12-08
Release date:2011-03-23
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:solution structure of Taf14 YEATS domain
To be Published
8JG4
DownloadVisualize
BU of 8jg4 by Molmil
Crystal Structure of YAF9A YEATS bound to H3K27cr peptide
Descriptor: Histone H3.1, Transcription initiation factor TFIID subunit 14b
Authors:Li, H.T, Liu, W.Q.
Deposit date:2023-05-19
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of YAF9A YEATS bound to H3K27cr peptide
To Be Published
5R68
DownloadVisualize
BU of 5r68 by Molmil
XChem group deposition -- Crystal Structure of human YEATS4 in complex with FM000199e
Descriptor: (1-methylbenzotriazol-5-yl)methanol, 1,2-ETHANEDIOL, YEATS domain-containing protein 4
Authors:Raux, B, Krojer, T, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Huber, K.V.M.
Deposit date:2020-02-29
Release date:2020-12-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:XChem group deposition
To Be Published
8PJI
DownloadVisualize
BU of 8pji by Molmil
MLLT1 in complex with compound 10a
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Protein ENL, ...
Authors:Raux, B, Diaz-Saez, L, Huber, K.V.M, Fedorov, O, Owen, D.R, Londregan, A.T, Bountra, C, Edwards, A, Arrowsmith, C.
Deposit date:2023-06-23
Release date:2023-11-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
Bioorg.Med.Chem.Lett., 98, 2023
8PJ7
DownloadVisualize
BU of 8pj7 by Molmil
MLLT3 in complex with compound PFI-6
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, PHOSPHATE ION, ...
Authors:Raux, B, Diaz-Saez, L, Huber, K.V.M, Fedorov, O, Owen, D.R, Londregan, A.T, Bountra, C, Edwards, A, Arrowsmith, C.
Deposit date:2023-06-22
Release date:2023-11-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
Bioorg.Med.Chem.Lett., 98, 2023
5R69
DownloadVisualize
BU of 5r69 by Molmil
XChem group deposition -- Crystal Structure of human YEATS4 in complex with XS038644e
Descriptor: 1,2-ETHANEDIOL, YEATS domain-containing protein 4, ~{N}-(5-oxidanylidene-7,8-dihydro-6~{H}-naphthalen-2-yl)ethanamide
Authors:Raux, B, Krojer, T, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Huber, K.V.M.
Deposit date:2020-02-29
Release date:2020-12-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:XChem group deposition
To Be Published
2NDF
DownloadVisualize
BU of 2ndf by Molmil
Solution NMR structures of AF9 yeats domain in complex with histon H3 acetylation at K18
Descriptor: Histone H3 peptide, Protein AF-9
Authors:Zeng, L, Zhou, M.
Deposit date:2016-05-19
Release date:2016-09-07
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Structure, 24, 2016
2NDG
DownloadVisualize
BU of 2ndg by Molmil
Solution NMR structures of AF9 yeats domain in complex with histone H3 crotonylation at K18
Descriptor: Histone H3 peptide, Protein AF-9
Authors:Zeng, L, Zhou, M.
Deposit date:2016-05-19
Release date:2016-09-07
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Structure, 24, 2016
8I60
DownloadVisualize
BU of 8i60 by Molmil
Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr
Descriptor: ALA-ARG-KCR-SER-ALA-PRO, GLYCEROL, SULFATE ION, ...
Authors:Konuma, T, Zhou, M.-M.
Deposit date:2023-01-26
Release date:2023-07-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.
Mol.Cell, 83, 2023
8IJ0
DownloadVisualize
BU of 8ij0 by Molmil
Crystal structure of GAS41 YEATS domain in complex with H3K9ac peptide
Descriptor: GLYCEROL, Histone H3.1, PENTAETHYLENE GLYCOL, ...
Authors:Kikuchi, M, Umehara, T.
Deposit date:2023-02-24
Release date:2023-11-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain.
Proc.Natl.Acad.Sci.USA, 120, 2023

 

123>

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon