1DD7
  • Download 1dd7
  • View 1dd7
Molmil generated image of 1dd7
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114) (N-[(1,3-BENZODIOXOL-5-YL)METHYL]-1-[2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL]-4-(METHOXYCARBONYL)-PIPERAZINE-2-ACETAMIDE COMPLEX
Descriptor:INDUCIBLE NITRIC OXIDE SYNTHASE (E.C.1.14.13.39)
Authors:Adler, M., Whitlow, M.
Deposit date:1999-11-08
Release date:2000-03-29
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry.
Proc.Natl.Acad.Sci.USA, 97, 2000
1DF1
  • Download 1df1
  • View 1df1
Molmil generated image of 1df1
MURINE INOSOXY DIMER WITH ISOTHIOUREA BOUND IN THE ACTIVE SITE
Descriptor:NITRIC OXIDE SYNTHASE (E.C.1.14.13.39)
Authors:Crane, B.R., Rosenfeld, R.J., Arvai, A.S., Ghosh, D.K., Ghosh, S., Tainer, J.A., Stuehr, D.J., Getzoff, E.D.
Deposit date:1999-11-16
Release date:1999-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.
EMBO J., 18, 1999
1DWV
  • Download 1dwv
  • View 1dwv
Molmil generated image of 1dwv
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-HYDROXYARGININE AND 4-AMINO TETRAHYDROBIOPTERIN
Descriptor:NITRIC OXIDE SYNTHASE (E.C.1.14.13.39)
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1999-12-14
Release date:2000-02-06
Last modified:2009-06-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures of the N(Omega)-Hydroxy-L-Arginine Complex of Inducible Nitric Oxide Synthase Oxygenase Dimer with Active Andinactive Pterins
Biochemistry, 39, 2000
1DWW
  • Download 1dww
  • View 1dww
Molmil generated image of 1dww
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-HYDROXYARGININE AND DIHYDROBIOPTERIN
Descriptor:NITRIC OXIDE SYNTHASE (E.C.1.14.13.39)
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1999-12-14
Release date:2000-02-06
Last modified:2009-06-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures of the N(Omega)-Hydroxy-L-Arginine Complex of Inducible Nitric Oxide Synthase Oxygenase Dimer with Active Andinactive Pterins
Biochemistry, 39, 2000
1DWX
  • Download 1dwx
  • View 1dwx
Molmil generated image of 1dwx
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-HYDROXYARGININE AND TETRAHYDROBIOPTERIN
Descriptor:NITRIC OXIDE SYNTHASE (E.C.1.14.13.39)
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1999-12-14
Release date:2000-02-06
Last modified:2009-06-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of the N(Omega)-Hydroxy-L-Arginine Complex of Inducible Nitric Oxide Synthase Oxygenase Dimer with Active Andinactive Pterins
Biochemistry, 39, 2000
1JWJ
  • Download 1jwj
  • View 1jwj
Molmil generated image of 1jwj
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH W457F MUTATION AT TETRAHYDROBIOPTERIN BINDING SITE
Descriptor:Nitric Oxide Synthase, Inducible
Authors:Aoyagi, M., Arvai, A.S., Ghosh, S., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2001-09-04
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Biochemistry, 40, 2001
1JWK
  • Download 1jwk
  • View 1jwk
Molmil generated image of 1jwk
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH W457A MUTATION AT TETRAHYDROBIOPTERIN BINDING SITE
Descriptor:Nitric Oxide Synthase, Inducible
Authors:Aoyagi, M., Arvai, A.S., Ghosh, S., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2001-09-04
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Biochemistry, 40, 2001
1K2R
  • Download 1k2r
  • View 1k2r
Molmil generated image of 1k2r
STRUCTURE OF RAT BRAIN NNOS HEME DOMAIN COMPLEXED WITH NG-NITRO-L-ARGININE
Descriptor:nitric-oxide synthase (E.C.1.14.13.39)
Authors:Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L., Raman, C.S.
Deposit date:2001-09-28
Release date:2003-03-04
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of rat brain nNOS heme domain
To be Published
1K2S
  • Download 1k2s
  • View 1k2s
Molmil generated image of 1k2s
STRUCTURE OF RAT BRAIN NNOS HEME DOMAIN COMPLEXED WITH NG-ALLYL-L-ARGININE
Descriptor:nitric-oxide synthase (E.C.1.14.13.39)
Authors:Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L., Raman, C.S.
Deposit date:2001-09-28
Release date:2003-03-04
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of rat brain nNOS heme domain
To be Published
1K2T
  • Download 1k2t
  • View 1k2t
Molmil generated image of 1k2t
STRUCTURE OF RAT BRAIN NNOS HEME DOMAIN COMPLEXED WITH S-ETHYL-N-PHENYL-ISOTHIOUREA
Descriptor:nitric-oxide synthase (E.C.1.14.13.39)
Authors:Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L., Raman, C.S.
Deposit date:2001-09-28
Release date:2003-03-04
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of rat brain nNOS heme domain
To be Published
1K2U
  • Download 1k2u
  • View 1k2u
Molmil generated image of 1k2u
STRUCTURE OF RAT BRAIN NNOS HEME DOMAIN COMPLEXED WITH S-ETHYL-N-[4-(TRIFLUOROMETHYL)PHENYL] ISOTHIOUREA
Descriptor:nitric-oxide synthase (E.C.1.14.13.39)
Authors:Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L., Raman, C.S.
Deposit date:2001-09-28
Release date:2003-03-04
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of rat brain nNOS heme domain
To be Published
1LZX
  • Download 1lzx
  • View 1lzx
Molmil generated image of 1lzx
RAT NEURONAL NOS HEME DOMAIN WITH NG-HYDROXY-L-ARGININE BOUND
Descriptor:Nitric-oxide synthase (E.C.1.14.13.39)
Authors:Li, H., Shimizu, H., Flinspach, M., Jamal, J., Yang, W., Xian, M., Cai, T., Wen, E.Z., Jia, Q., Wang, P.G., Poulos, T.L.
Deposit date:2002-06-11
Release date:2002-11-27
Last modified:2010-10-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide Synthase Provides Mechanistic Insights into NO Biosynthesis
Biochemistry, 41, 2002
1LZZ
  • Download 1lzz
  • View 1lzz
Molmil generated image of 1lzz
RAT NEURONAL NOS HEME DOMAIN WITH N-ISOPROPYL-N'-HYDROXYGUANIDINE BOUND
Descriptor:Nitric-oxide synthase (E.C.1.14.13.39)
Authors:Li, H., Shimizu, H., Flinspach, M., Jamal, J., Yang, W., Xian, M., Cai, T., Wen, E.Z., Jia, Q., Wang, P.G., Poulos, T.L.
Deposit date:2002-06-11
Release date:2002-11-27
Last modified:2010-10-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide Synthase Provides Mechanistic Insights into NO Biosynthesis
Biochemistry, 41, 2002
1M00
  • Download 1m00
  • View 1m00
Molmil generated image of 1m00
RAT NEURONAL NOS HEME DOMAIN WITH N-BUTYL-N'-HYDROXYGUANIDINE BOUND
Descriptor:Nitric-oxide synthase (E.C.1.14.13.39)
Authors:Li, H., Shimizu, H., Flinspach, M., Jamal, J., Yang, W., Xian, M., Cai, T., Wen, E.Z., Jia, Q., Wang, P.G., Poulos, T.L.
Deposit date:2002-06-11
Release date:2002-11-27
Last modified:2010-10-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide Synthase Provides Mechanistic Insights into NO Biosynthesis
Biochemistry, 41, 2002
1M8D
  • Download 1m8d
  • View 1m8d
Molmil generated image of 1m8d
INDUCIBLE NITRIC OXIDE SYNTHASE WITH CHLORZOXAZONE BOUND
Descriptor:Inducible Nitric Oxide Synthase
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-24
Release date:2002-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M8E
  • Download 1m8e
  • View 1m8e
Molmil generated image of 1m8e
INDUCIBLE NITRIC OXIDE SYNTHASE WITH 7-NITROINDAZOLE BOUND
Descriptor:inducible Nitric oxide synthase, (E.C.1.14.13.39)
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-24
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M8H
  • Download 1m8h
  • View 1m8h
Molmil generated image of 1m8h
INDUCIBLE NITRIC OXIDE SYNTHASE WITH 6-NITROINDAZOLE BOUND
Descriptor:inducible Nitric oxide synthase
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-24
Release date:2002-08-07
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M8I
  • Download 1m8i
  • View 1m8i
Molmil generated image of 1m8i
INDUCIBLE NITRIC OXIDE SYNTHASE WITH 5-NITROINDAZOLE BOUND
Descriptor:inducible Nitric oxide synthase
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-24
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9J
  • Download 1m9j
  • View 1m9j
Molmil generated image of 1m9j
HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH CHLORZOXAZONE BOUND
Descriptor:endothelial Nitric-oxide synthase (E.C.1.14.13.39)
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-29
Release date:2002-08-14
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9K
  • Download 1m9k
  • View 1m9k
Molmil generated image of 1m9k
HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH 7-NITROINDAZOLE BOUND
Descriptor:endothelial Nitric-oxide synthase (E.C.1.14.13.39)
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-29
Release date:2002-08-14
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9M
  • Download 1m9m
  • View 1m9m
Molmil generated image of 1m9m
HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH 6-NITROINDAZOLE BOUND
Descriptor:endothelial Nitric-oxide synthase (E.C.1.14.13.39)
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-29
Release date:2002-08-07
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9Q
  • Download 1m9q
  • View 1m9q
Molmil generated image of 1m9q
HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH 5-NITROINDAZOLE BOUND
Descriptor:endothelial Nitric-oxide synthase (E.C.1.14.13.39)
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-29
Release date:2002-08-07
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9R
  • Download 1m9r
  • View 1m9r
Molmil generated image of 1m9r
HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH 3-BROMO-7-NITROINDAZOLE BOUND
Descriptor:endothelial Nitric-oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 3-BROMO-7-NITROINDAZOLE
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-29
Release date:2002-08-14
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9T
  • Download 1m9t
  • View 1m9t
Molmil generated image of 1m9t
INDUCIBLE NITRIC OXIDE SYNTHASE WITH 3-BROMO-7-NITROINDAZOLE BOUND
Descriptor:inducible nitric oxide synthase
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-09-05
Release date:2002-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1MMV
  • Download 1mmv
  • View 1mmv
Molmil generated image of 1mmv
RAT NEURONAL NOS HEME DOMAIN WITH NG-PROPYL-L-ARGININE BOUND
Descriptor:nitric-oxide synthase (E.C.1.14.13.39)
Authors:Bretscher, L.E., Li, H., Poulos, T.L., Griffith, O.W.
Deposit date:2002-09-04
Release date:2003-09-16
Last modified:2010-10-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines
J.Biol.Chem., 278, 2003
PDBj@FacebookPDBj@TwitterwwPDBwwPDB FoundationEM DataBank

Copyright © 2013-2017 Protein Data Bank Japan