6CIC
Structure of the human nitric oxide synthase R354A/G357D mutant heme domain in complex with N-(1-(2-(Ethyl(methyl)amino)ethyl)-1,2,3,4-tetrahydroquino-lin-6-yl)thiophene-2-carboximidamide
Summary for 6CIC
Entry DOI | 10.2210/pdb6cic/pdb |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 100219.06 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2018-02-23, release date: 2018-10-31, Last modification date: 2023-10-04) |
Primary citation | Li, H.,Evenson, R.J.,Chreifi, G.,Silverman, R.B.,Poulos, T.L. Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides. Biochemistry, 57:6319-6325, 2018 Cited by PubMed: 30335983DOI: 10.1021/acs.biochem.8b00895 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.752 Å) |
Structure validation
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