Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8VHQ
DownloadVisualize
BU of 8vhq by Molmil
Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and ATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
8VHO
DownloadVisualize
BU of 8vho by Molmil
Crystal Structure of E. coli class Ia ribonucleotide reductase alpha subunit bound to dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
8VHR
DownloadVisualize
BU of 8vhr by Molmil
Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and GTP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
8VHP
DownloadVisualize
BU of 8vhp by Molmil
Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to CDP and two molecules of ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (2.608 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
8VHN
DownloadVisualize
BU of 8vhn by Molmil
Crystal Structure of E. coli class Ia ribonucleotide reductase alpha subunit bound to two ATP molecules
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
8VHU
DownloadVisualize
BU of 8vhu by Molmil
Crystal structure of dATP bound E. coli class Ia ribonucleotide reductase alpha construct fused with the C-terminal tail of E. coli class Ia beta subunit
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CHLORIDE ION, Fusion protein of Ribonucleoside-diphosphate reductase 1 subunits alpha and beta, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
7URG
DownloadVisualize
BU of 7urg by Molmil
cryo-EM structure of ribonucleotide reductase from Synechococcus phage S-CBP4 bound with TTP
Descriptor: Ribonucleotide reductase, THYMIDINE-5'-TRIPHOSPHATE
Authors:Xu, D, Burnim, A.A, Ando, N.
Deposit date:2022-04-21
Release date:2022-09-07
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade.
Elife, 11, 2022
7RW6
DownloadVisualize
BU of 7rw6 by Molmil
BORF2-APOBEC3Bctd Complex
Descriptor: DNA dC->dU-editing enzyme APOBEC-3B, Maltose/maltodextrin-binding periplasmic protein,Ribonucleoside-diphosphate reductase large subunit, ZINC ION
Authors:Shaban, N.M, Yan, R, Shi, K, McLellan, J.S, Yu, Z, Harris, R.S.
Deposit date:2021-08-19
Release date:2022-04-27
Last modified:2022-05-04
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.
Sci Adv, 8, 2022
7MDI
DownloadVisualize
BU of 7mdi by Molmil
Structure of the Neisseria gonorrhoeae ribonucleotide reductase in the inactive state
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Levitz, T.S, Drennan, C.L, Brignole, E.J.
Deposit date:2021-04-05
Release date:2022-01-05
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Effects of chameleon dispense-to-plunge speed on particle concentration, complex formation, and final resolution: A case study using the Neisseria gonorrhoeae ribonucleotide reductase inactive complex.
J.Struct.Biol., 214, 2021
7B9Q
DownloadVisualize
BU of 7b9q by Molmil
The SERp optimized structure of Ribonucleotide reductase from Rhodobacter sphaeroides
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Vitamin B12-dependent ribonucleotide reductase
Authors:Loderer, C, Feiler, C, Wilk, P, Kabinger, F.
Deposit date:2020-12-14
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase.
Biochemistry, 61, 2022
7B9P
DownloadVisualize
BU of 7b9p by Molmil
Structure of Ribonucleotide reductase from Rhodobacter sphaeroides
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Vitamin B12-dependent ribonucleotide reductase
Authors:Wilk, P, Feiler, C, Loderer, C, Kabinger, F.
Deposit date:2020-12-14
Release date:2022-01-12
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.646 Å)
Cite:HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase.
Biochemistry, 61, 2022
7AGJ
DownloadVisualize
BU of 7agj by Molmil
Ribonucleotide Reductase R1 protein from Aquifex aeolicus
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Rehling, D, Scaletti, E.R, Stenmark, P.
Deposit date:2020-09-22
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
Biochemistry, 61, 2022
6W4X
DownloadVisualize
BU of 6w4x by Molmil
Holocomplex of E. coli class Ia ribonucleotide reductase with GDP and TTP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MU-OXO-DIIRON, ...
Authors:Kang, G, Taguchi, A, Stubbe, J, Drennan, C.
Deposit date:2020-03-11
Release date:2020-04-08
Last modified:2020-05-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex.
Science, 368, 2020
6LKM
DownloadVisualize
BU of 6lkm by Molmil
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide
Descriptor: 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ...
Authors:Miyahara, S, Chong, K.T, Suzuki, T.
Deposit date:2019-12-19
Release date:2020-12-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published
6L7L
DownloadVisualize
BU of 6l7l by Molmil
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide
Descriptor: 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide, ACETATE ION, MAGNESIUM ION, ...
Authors:Miyahara, S, Chong, K.T, Suzuki, T.
Deposit date:2019-11-01
Release date:2020-11-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.171 Å)
Cite:TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published
6L3R
DownloadVisualize
BU of 6l3r by Molmil
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide
Descriptor: 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide, ACETATE ION, MAGNESIUM ION, ...
Authors:Miyahara, S, Chong, K.T, Suzuki, T.
Deposit date:2019-10-15
Release date:2020-10-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published
6MYX
DownloadVisualize
BU of 6myx by Molmil
EM structure of Bacillus subtilis ribonucleotide reductase inhibited double-helical filament of NrdE alpha subunit with dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Ribonucleoside-diphosphate reductase
Authors:Thomas, W.C, Bacik, J.P, Chen, J.Z, Ando, N.
Deposit date:2018-11-02
Release date:2019-06-19
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6MW3
DownloadVisualize
BU of 6mw3 by Molmil
EM structure of Bacillus subtilis ribonucleotide reductase inhibited filament composed of NrdE alpha subunit and NrdF beta subunit with dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Ribonucleoside-diphosphate reductase, Ribonucleoside-diphosphate reductase NrdF beta subunit
Authors:Thomas, W.C, Bacik, J.P, Kaelber, J.T, Ando, N.
Deposit date:2018-10-29
Release date:2019-06-19
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.65 Å)
Cite:Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6MVE
DownloadVisualize
BU of 6mve by Molmil
Reduced X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N.
Deposit date:2018-10-25
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6MV9
DownloadVisualize
BU of 6mv9 by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase, ...
Authors:Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N.
Deposit date:2018-10-24
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6MT9
DownloadVisualize
BU of 6mt9 by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N.
Deposit date:2018-10-19
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6DQX
DownloadVisualize
BU of 6dqx by Molmil
Actinobacillus ureae class Id ribonucleotide reductase alpha subunit
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
Authors:McBride, M.J, Palowitch, G.M, Boal, A.K.
Deposit date:2018-06-11
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis.
Biochemistry, 58, 2019
6DQW
DownloadVisualize
BU of 6dqw by Molmil
Flavobacterium johnsoniae class Id ribonucleotide reductase alpha subuint
Descriptor: Ribonucleoside-diphosphate reductase, alpha chain
Authors:Maggiolo, A.O, Boal, A.K.
Deposit date:2018-06-11
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis.
Biochemistry, 58, 2019
6CGL
DownloadVisualize
BU of 6cgl by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound as-isolated (pH 4)
Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Ribonucleoside-diphosphate reductase, SULFATE ION
Authors:Maggiolo, A.O, Boal, A.K.
Deposit date:2018-02-20
Release date:2018-05-09
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGN
DownloadVisualize
BU of 6cgn by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound (pH 7)
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ...
Authors:Maggiolo, A.O, Boal, A.K.
Deposit date:2018-02-20
Release date:2018-05-09
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018

 

1234>

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon