8HAN
| Cryo-EM structure of the CBP catalytic core bound to the H4K12acK16ac nucleosome, class 3 | Descriptor: | CREB-binding protein, DNA (180-mer), Histone H2A type 1-B/E, ... | Authors: | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | Deposit date: | 2022-10-26 | Release date: | 2023-05-17 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8HAM
| Cryo-EM structure of the CBP catalytic core bound to the H4K12acK16ac nucleosome, class 2 | Descriptor: | CREB-binding protein, DNA (180-mer), Histone H2A type 1-B/E, ... | Authors: | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | Deposit date: | 2022-10-26 | Release date: | 2023-05-17 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8HAL
| Cryo-EM structure of the CBP catalytic core bound to the H4K12acK16ac nucleosome, class 1 | Descriptor: | CREB-binding protein, DNA (180-mer), Histone H2A type 1-B/E, ... | Authors: | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | Deposit date: | 2022-10-26 | Release date: | 2023-05-17 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8HAK
| Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 4 (4.5 angstrom resolution) | Descriptor: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | Deposit date: | 2022-10-26 | Release date: | 2023-05-17 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8HAJ
| Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 2 (4.8 angstrom resolution) | Descriptor: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | Deposit date: | 2022-10-26 | Release date: | 2023-05-17 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8HAI
| Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 1 (4.7 angstrom resolution) | Descriptor: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | Deposit date: | 2022-10-26 | Release date: | 2023-05-17 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8HAH
| Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 2 (3.9 angstrom resolution) | Descriptor: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | Deposit date: | 2022-10-26 | Release date: | 2023-05-17 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8HAG
| Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 1 (3.2 angstrom resolution) | Descriptor: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | Deposit date: | 2022-10-26 | Release date: | 2023-05-17 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nat Commun, 14, 2023
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8E1D
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7XFG
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7XEZ
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7QGS
| Crystal structure of p300 CH1 domain in complex with CITIF (a CITED2-HIF-1alpha hybrid) | Descriptor: | Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone acetyltransferase, ZINC ION | Authors: | Hegedus, Z, Wilson, A.J, Edwards, T.A. | Deposit date: | 2021-12-10 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Understanding p300-transcription factor interactions using sequence variation and hybridization. Rsc Chem Biol, 3, 2022
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7LVS
| The CBP TAZ1 Domain in Complex with a CITED2-HIF-1-Alpha Fusion Peptide | Descriptor: | Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone lysine acetyltransferase CREBBP, ZINC ION | Authors: | Appling, F.D, Berlow, R.B, Stanfield, R.L, Dyson, H.J, Wright, P.E. | Deposit date: | 2021-02-26 | Release date: | 2021-07-28 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | The molecular basis of allostery in a facilitated dissociation process. Structure, 29, 2021
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6FGS
| Solution structure of p300Taz2-p73TA1 | Descriptor: | Histone acetyltransferase p300,Tumor protein p73, ZINC ION | Authors: | Gebel, J, Kazemi, S, Lohr, F, Guntert, P, Dotsch, V. | Deposit date: | 2018-01-11 | Release date: | 2018-05-30 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain. Structure, 26, 2018
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6FGN
| Solution Structure of p300Taz2-p63TA | Descriptor: | Histone acetyltransferase p300,Tumor protein 63, ZINC ION | Authors: | Gebel, J, Kazemi, S, Lohr, F, Guntert, P, Dotsch, V. | Deposit date: | 2018-01-11 | Release date: | 2018-05-30 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain. Structure, 26, 2018
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5HPD
| Solution Structure of TAZ2-p53TAD | Descriptor: | CREB-binding protein,Cellular tumor antigen p53 fusion protein, ZINC ION | Authors: | Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2016-01-20 | Release date: | 2016-03-16 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc.Natl.Acad.Sci.USA, 113, 2016
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5HP0
| Solution Structure of TAZ2-p53AD2 | Descriptor: | CREB-binding protein,Cellular tumor antigen p53 fusion protein, ZINC ION | Authors: | Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2016-01-19 | Release date: | 2016-03-16 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc.Natl.Acad.Sci.USA, 113, 2016
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5HOU
| Solution Structure of p53TAD-TAZ1 | Descriptor: | Cellular tumor antigen p53,CREB-binding protein fusion protein, ZINC ION | Authors: | Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2016-01-19 | Release date: | 2016-03-16 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc.Natl.Acad.Sci.USA, 113, 2016
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3T92
| Crystal structure of the Taz2:C/EBPepsilon-TAD chimera protein | Descriptor: | 3,3',3''-phosphanetriyltripropanoic acid, ACETONE, HISTONE ACETYLTRANSFERASE P300 TAZ2-CCAAT/ENHANCER-BINDING PROTEIN EPSILON, ... | Authors: | Bhaumik, P, Maria, M. | Deposit date: | 2011-08-02 | Release date: | 2012-08-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300. Acta Crystallogr. D Biol. Crystallogr., 70, 2014
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3P57
| Crystal structure of the p300 TAZ2 domain bound to MEF2 on DNA | Descriptor: | DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), Histone acetyltransferase p300, ... | Authors: | He, J, Ye, J, Riquelme, C, Liu, J.O. | Deposit date: | 2010-10-08 | Release date: | 2011-08-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1921 Å) | Cite: | Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly. Nucleic Acids Res., 39, 2011
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3IO2
| Crystal structure of the Taz2 domain of p300 | Descriptor: | Histone acetyltransferase p300, SULFATE ION, ZINC ION | Authors: | Miller, M, Dauter, Z, Wlodawer, A. | Deposit date: | 2009-08-13 | Release date: | 2009-11-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Taz2 domain of p300: insights into ligand binding. Acta Crystallogr.,Sect.D, 65, 2009
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2MZD
| Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex | Descriptor: | Cellular tumor antigen p53, Histone acetyltransferase p300 | Authors: | Miller Jenkins, L.M, Feng, H, Durell, S.R, Tagad, H.D, Mazur, S.J, Tropea, J.E, Bai, Y, Appella, E. | Deposit date: | 2015-02-11 | Release date: | 2015-03-25 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex. Biochemistry, 54, 2015
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2MH0
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2LWW
| NMR structure of RelA-TAD/CBP-TAZ1 complex | Descriptor: | CREB-binding protein, Nuclear transcription factor RelA, ZINC ION | Authors: | Mukherjee, S.P, Ghosh, G, Wright, P.E. | Deposit date: | 2012-08-07 | Release date: | 2013-09-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Analysis of the RelA:CBP/p300 Interaction Reveals Its Involvement in NF-kappa B-Driven Transcription. Plos Biol., 11, 2013
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2KJE
| NMR structure of CBP TAZ2 and adenoviral E1A complex | Descriptor: | CREB-binding protein, Early E1A 32 kDa protein, ZINC ION | Authors: | Ferreon, J.C, Martinez-Yamout, M, Dyson, H, Wright, P.E. | Deposit date: | 2009-05-27 | Release date: | 2009-09-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. Proc.Natl.Acad.Sci.USA, 106, 2009
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