7QGS

Crystal structure of p300 CH1 domain in complex with CITIF (a CITED2-HIF-1alpha hybrid)

Summary for 7QGS

Entry DOI	10.2210/pdb7qgs/pdb
Descriptor	Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone acetyltransferase, ZINC ION, ... (4 entities in total)
Functional Keywords	hypoxia, transcription factor, intrinsically disordered protein, protein binding
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	17491.15
Authors	Hegedus, Z.,Wilson, A.J.,Edwards, T.A. (deposition date: 2021-12-10, release date: 2022-05-11, Last modification date: 2024-01-31)
Primary citation	Hobor, F.,Hegedus, Z.,Ibarra, A.A.,Petrovicz, V.L.,Bartlett, G.J.,Sessions, R.B.,Wilson, A.J.,Edwards, T.A. Understanding p300-transcription factor interactions using sequence variation and hybridization. Rsc Chem Biol, 3:592-603, 2022 Cited by PubMed: 35656479 DOI: 10.1039/d2cb00026a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation