7QGS

Crystal structure of p300 CH1 domain in complex with CITIF (a CITED2-HIF-1alpha hybrid)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha	polymer	58	6402.2	1	UniProt (Q99967) UniProt (Q16665) Pfam (PF08778) In PDB	Homo sapiens	MSG-related protein 1,MRG-1,P35srj,HIF-1-alpha,HIF1-alpha,ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,Class E basic helix-loop-helix protein 78,bHLHe78,Member of PAS protein 1,PAS domain-containing protein 8
2	A	Histone acetyltransferase	polymer	96	10892.7	1	UniProt (Q7Z6C1) Pfam (PF02135) UniProt (by SIFTS) (Q09472) In PDB	Homo sapiens (human)
3	A	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
4		water	water		18.0	41	Chemie (HOH)

Sequence modifications

B: 5 - 23 (UniProt: Q99967)

PDB	External Database	Details
Gly 1	-	expression tag
Pro 2	-	expression tag
Gly 3	-	expression tag
Ser 4	-	expression tag

B: 24 - 58 (UniProt: Q16665)
A: 330 - 420 (UniProt: Q7Z6C1)

PDB	External Database	Details
Gly 325	-	expression tag
Pro 326	-	expression tag
Ile 327	-	expression tag
Gly 328	-	expression tag
Ser 329	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	17294.9
Non-Polymers*	Number of molecules	3
	Total formula weight	196.2
All*	Total formula weight	17491.1

*Water molecules are not included.