8P6M
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8P5N
| Arsenate reductase (ArsC2) from Deinococcus indicus, co-crystallized with arsenate | Descriptor: | ARSENATE, GLYCEROL, Low molecular weight phosphatase family protein | Authors: | Gouveia, A.G, Matias, P.M, Romao, C.V. | Deposit date: | 2023-05-24 | Release date: | 2023-08-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Unraveling the multifaceted resilience of arsenic resistant bacterium Deinococcus indicus . Front Microbiol, 14, 2023
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7UW6
| The co-crystal structure of low molecular weight protein tyrosine phosphatase (LMW-PTP) with a small molecule inhibitor SPAA-2 | Descriptor: | 2-[(1,3-benzothiazol-2-yl)amino]-2-oxoethane-1-sulfonic acid, Low molecular weight phosphotyrosine protein phosphatase | Authors: | Wang, J, Zhang, Z.Y. | Deposit date: | 2022-05-02 | Release date: | 2022-10-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. J.Med.Chem., 65, 2022
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7PUA
| Middle assembly intermediate of the Trypanosoma brucei mitoribosomal small subunit | Descriptor: | 30S Ribosomal protein S17, putative, 30S ribosomal protein S8, ... | Authors: | Lenarcic, T, Leibundgut, M, Saurer, M, Ramrath, D.J.F, Fluegel, T, Boehringer, D, Ban, N. | Deposit date: | 2021-09-29 | Release date: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mitoribosomal small subunit maturation involves formation of initiation-like complexes. Proc.Natl.Acad.Sci.USA, 119, 2022
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7DHF
| Vibrio vulnificus Wzb in complex with benzylphosphonate | Descriptor: | GLYCEROL, PHOSPHATE ION, Protein-tyrosine-phosphatase | Authors: | Ma, Q, Wang, X. | Deposit date: | 2020-11-14 | Release date: | 2021-01-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.211 Å) | Cite: | Wzb of Vibrio vulnificus represents a new group of low-molecular-weight protein tyrosine phosphatases with a unique insertion in the W-loop. J.Biol.Chem., 296, 2021
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7DHE
| Vibrio vulnificus Wzb in complex with benzylphosphonate | Descriptor: | Protein-tyrosine-phosphatase, benzylphosphonic acid | Authors: | Ma, Q, Wang, X. | Deposit date: | 2020-11-14 | Release date: | 2021-01-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Wzb of Vibrio vulnificus represents a new group of low-molecular-weight protein tyrosine phosphatases with a unique insertion in the W-loop. J.Biol.Chem., 296, 2021
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7DHD
| Vibrio vulnificus Wzb | Descriptor: | CHLORIDE ION, Protein-tyrosine-phosphatase | Authors: | Ma, Q, Wang, X. | Deposit date: | 2020-11-14 | Release date: | 2021-01-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Wzb of Vibrio vulnificus represents a new group of low-molecular-weight protein tyrosine phosphatases with a unique insertion in the W-loop. J.Biol.Chem., 296, 2021
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7KH8
| Human LMPTP in complex with inhibitor | Descriptor: | 3-[(2,6-dichlorophenyl)methyl]-8-(2-methylphenyl)-3H-purin-6-amine, Low molecular weight phosphotyrosine protein phosphatase, NITRATE ION | Authors: | Stanford, S.M, Diaz, M.A, Ardecky, R.J, Zou, J, Roosild, T, Holmes, Z.J, Hedrick, M.P, Rodiles, S, Santelli, E, Chung, T.D.Y, Jackson, M.R, Bottini, N, Pinkerton, A.B. | Deposit date: | 2020-10-20 | Release date: | 2021-05-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. J.Med.Chem., 64, 2021
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7CUY
| Crystal structure of Primo-1 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Low molecular weight phosphotyrosine protein phosphatase 1 | Authors: | Lee, H.S, Kim, S.J, Ku, B. | Deposit date: | 2020-08-25 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.081 Å) | Cite: | Structural and Biochemical Characterization of the Two Drosophila Low Molecular Weight-Protein Tyrosine Phosphatases DARP and Primo-1. Mol.Cells, 43, 2020
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7BTG
| Crystal structure of DARP, drosophila arginine phosphatase | Descriptor: | CHLORIDE ION, GEO10716p1, PHOSPHATE ION | Authors: | Lee, H.S, Mo, Y, Ku, B, Kim, S.J. | Deposit date: | 2020-04-01 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.188 Å) | Cite: | Structural and Biochemical Characterization of the Two Drosophila Low Molecular Weight-Protein Tyrosine Phosphatases DARP and Primo-1. Mol.Cells, 43, 2020
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6Y2V
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6Y2W
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6U1P
| Crystal structure of VpsU (VC0916) from Vibrio cholerae | Descriptor: | GLYCEROL, Low molecular weight phosphotyrosine protein phosphatase | Authors: | Tripathi, S.M, Schwechheimer, C, Herbert, K, Osorio, J, Yildiz, F.H, Rubin, S.M. | Deposit date: | 2019-08-16 | Release date: | 2020-08-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae. Plos Pathog., 16, 2020
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6SGA
| Body domain of the mt-SSU assemblosome from Trypanosoma brucei | Descriptor: | 9S rRNA, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Saurer, M, Ramrath, D.J.F, Niemann, M, Calderaro, S, Prange, C, Mattei, S, Scaiola, A, Leitner, A, Bieri, P, Horn, E.K, Leibundgut, M, Boehringer, D, Schneider, A, Ban, N. | Deposit date: | 2019-08-03 | Release date: | 2019-09-18 | Last modified: | 2019-09-25 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery. Science, 365, 2019
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6SGB
| mt-SSU assemblosome of Trypanosoma brucei | Descriptor: | 9S rRNA, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Saurer, M, Ramrath, D.J.F, Niemann, M, Calderaro, S, Prange, C, Mattei, S, Scaiola, A, Leitner, A, Bieri, P, Horn, E.K, Leibundgut, M, Boehringer, D, Schneider, A, Ban, N. | Deposit date: | 2019-08-03 | Release date: | 2019-09-25 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery. Science, 365, 2019
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5Z3M
| Crystal structure of Low Molecular Weight Phosphotyrosine phosphatase (VcLMWPTP-2) from Vibrio choleraeO395 | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, GLYCEROL, Phosphotyrosine protein phosphatase, ... | Authors: | Chatterjee, S, Nath, S, Sen, U. | Deposit date: | 2018-01-08 | Release date: | 2018-09-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Vibrio cholerae LMWPTP-2 display unique surface charge and grooves around the active site: Indicative of distinctive substrate specificity and scope to design specific inhibitor. Biochim Biophys Acta Proteins Proteom, 1867, 2019
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5O7B
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5GOT
| Crystal structure of SP-PTP, low molecular weight protein tyrosine phosphatase from Streptococcus pyogenes | Descriptor: | CHLORIDE ION, Low molecular weight phosphotyrosine phosphatase family protein | Authors: | Ku, B, Keum, C.W, KIim, S.J. | Deposit date: | 2016-07-29 | Release date: | 2016-09-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | Crystal structure of SP-PTP, a low molecular weight protein tyrosine phosphatase from Streptococcus pyogenes Biochem.Biophys.Res.Commun., 478, 2016
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5KQL
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5KQP
| Crystal structure of Apo-form LMW-PTP | Descriptor: | Low molecular weight phosphotyrosine protein phosphatase | Authors: | Wang, J, Zhang, Z.-Y, Yu, Z.-H. | Deposit date: | 2016-07-06 | Release date: | 2016-10-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.052 Å) | Cite: | Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. J.Med.Chem., 2016
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5KQG
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5KQM
| Co-crystal structure of LMW-PTP in complex with MES | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Low molecular weight phosphotyrosine protein phosphatase | Authors: | Wang, J, Zhang, Z.-Y, Yu, Z.-H. | Deposit date: | 2016-07-06 | Release date: | 2016-10-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. J.Med.Chem., 2016
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5JNS
| Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with phosphate | Descriptor: | DIMETHYL SULFOXIDE, Low molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION | Authors: | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | Deposit date: | 2016-04-30 | Release date: | 2017-03-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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5JNV
| Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with HEPES | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, Low molecular weight phosphotyrosine protein phosphatase | Authors: | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | Deposit date: | 2016-04-30 | Release date: | 2017-03-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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5JNT
| Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with MES | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ... | Authors: | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | Deposit date: | 2016-04-30 | Release date: | 2017-03-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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