1HTY
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GOLGI ALPHA-MANNOSIDASE II
Descriptor:(4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ALPHA-MANNOSIDASE II, ...
Authors:van den Elsen, J.M.H., Kuntz, D.A., Rose, D.R.
Deposit date:2001-01-02
Release date:2002-01-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1HWW
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GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE
Descriptor:(4R)-2-METHYLPENTANE-2,4-DIOL, 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL, ALPHA-MANNOSIDASE II, ...
Authors:van den Elsen, J.M.H., Kuntz, D.A., Rose, D.R.
Deposit date:2001-01-10
Release date:2002-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1HXK
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GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH DEOXYMANNOJIRIMICIN
Descriptor:(4R)-2-METHYLPENTANE-2,4-DIOL, 1-DEOXYMANNOJIRIMYCIN, ALPHA-MANNOSIDASE II, ...
Authors:van den Elsen, J.M.H., Kuntz, D.A., Rose, D.R.
Deposit date:2001-01-16
Release date:2002-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J., 20, 2001
1PS3
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GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH KIFUNENSINE
Descriptor:(4R)-2-METHYLPENTANE-2,4-DIOL, Alpha-mannosidase II, KIFUNENSINE, ...
Authors:Shah, N., Kuntz, D.A., Rose, D.R.
Deposit date:2003-06-20
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Comparison of Kifunensine and 1-Deoxymannojirimycin Binding to Class I and II alpha-Mannosidases Demonstrates Different Saccharide Distortions in Inverting and Retaining Catalytic Mechanisms
Biochemistry, 42, 2003
1QWN
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GOLGI ALPHA-MANNOSIDASE II COVALENT INTERMEDIATE COMPLEX WITH 5-FLUORO-GULOSYL-FLUORIDE
Descriptor:(4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-FLUORO-BETA-L-GULOSYL FLUORIDE, ...
Authors:Numao, S., Kuntz, D.A., Withers, S.G., Rose, D.R.
Deposit date:2003-09-02
Release date:2003-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
1QWU
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GOLGI ALPHA-MANNOSIDASE II D341N MUTANT COMPLEX WITH 5-F-GULOSIDE
Descriptor:(4S)-2-METHYL-2,4-PENTANEDIOL, 5-FLUORO-BETA-L-GULOSYL FLUORIDE, Alpha-mannosidase II, ...
Authors:Numao, S., Kuntz, D.A., Withers, S.G., Rose, D.R.
Deposit date:2003-09-03
Release date:2003-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
1QX1
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GOLGI ALPHA-MANNOSIDASE II D341N MUTANT COMPLEX WITH 2-F-MANNOSYL-F
Descriptor:(4S)-2-METHYL-2,4-PENTANEDIOL, 2-DEOXY-2-FLUOROHEXOPYRANOSYL FLUORIDE, Alpha-mannosidase II, ...
Authors:Numao, S., Kuntz, D.A., Withers, S.G., Rose, D.R.
Deposit date:2003-09-04
Release date:2003-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
J.Biol.Chem., 278, 2003
1R33
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH 5-THIO-D-MANNOPYRANOSYLAMINE
Descriptor:(4S)-2-METHYL-2,4-PENTANEDIOL, 5-THIO-A/B-D-MANNOPYRANOSYLAMINE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kuntz, D.A., Xin, W., Kavelekar, L.M., Rose, D.R., Pinto, B.M.
Deposit date:2003-09-30
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:5-Thio-d-glycopyranosylamines and their amidinium salts as potential transition-state mimics of glycosyl hydrolases: synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling
TETRAHEDRON ASYMMETRY, 16, 2005
1R34
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH 5-THIO-D-MANNOPYRANOSYLAMIDINIUM SALT
Descriptor:(4S)-2-METHYL-2,4-PENTANEDIOL, N-(1-IMINIO-2-PHENYLETHYL)-5-THIOHEXOPYRANOSYLAMINE BROMIDE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kuntz, D.A., Xin, W., Kavelekar, L.M., Rose, D.R., Pinto, B.M.
Deposit date:2003-09-30
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:5-Thio-d-glycopyranosylamines and their amidinium salts as potential transition-state mimics of glycosyl hydrolases: synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling
TETRAHEDRON ASYMMETRY, 16, 2005
1TQS
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GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SALACINOL
Descriptor:(4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2S,3S)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISULFONIUMYLIDENE]-D-ARABINITOL INNER SALT, Alpha-mannosidase II, ...
Authors:Kuntz, D.A., Ghavami, A., Johnston, B.D., Pinto, B.M., Rose, D.R.
Deposit date:2004-06-18
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
Tetrahedron Asymmetry, 16, 2005
1TQT
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GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH A DIASTEREOMER OF SALACINOL
Descriptor:(4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2R,3R)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISULFONIUMYLIDENE]-D-ARABINITOL INNER SALT, Alpha-mannosidase II, ...
Authors:Kuntz, D.A., Ghavami, A., Johnston, B.D., Pinto, B.M., Rose, D.R.
Deposit date:2004-06-18
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
Tetrahedron Asymmetry, 16, 2005
1TQU
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GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH THE SALACINOL ANALOG GHAVAMIOL
Descriptor:(4R)-2-METHYLPENTANE-2,4-DIOL, 1'-((1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL)-4-N-AMMONIUM)-1'-DEOXY-L-ERYTHRITOL-3'-SULFATE INNER SALT, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Kuntz, D.A., Ghavami, A., Johnston, B.D., Pinto, B.M., Rose, D.R.
Deposit date:2004-06-18
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
Tetrahedron Asymmetry, 16, 2005
1TQV
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GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SELENO-SALACINOL (BLINTOL)
Descriptor:(4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2S,3S)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISELENONIUMYLIDENE]-D-ARABINITOL INNER SALT, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Kuntz, D.A., Ghavami, A., Johnston, B.D., Pinto, B.M., Rose, D.R.
Deposit date:2004-06-18
Release date:2005-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
TETRAHEDRON ASYMMETRY, 16, 2005
1TQW
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GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH A DIASTEREOMER OF SELENO-SALACINOL
Descriptor:(4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2R,3R)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISELENONIUMYLIDENE]-D-ARABINITOL INNER SALT, Alpha-mannosidase II, ...
Authors:Kuntz, D.A., Ghavami, A., Johnston, B.D., Pinto, B.M., Rose, D.R.
Deposit date:2004-06-18
Release date:2005-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Insights into the Mechanism of Drosophila melanogaster Golgi a-Mannosidase II Through Crystallographic Analysis of the Interactions with Analogues of the Naturally Occurring Glycomimetic Salacinol
TETRAHEDRON ASYMMETRY, 16, 2005
2ALW
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH NOEUROMYCIN
Descriptor:(2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-mannosidase II, ...
Authors:Kuntz, D.A., Bols, M.B., Liu, H., Rose, D.R.
Deposit date:2005-08-08
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:The role of the active site Zn in the catalytic mechanism of the GH38 Golgi alpha-mannosidase II: implications from noeuromycin inhibition
Biocatal.Biotransfor., 34, 2006
2F18
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL
Descriptor:(2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-mannosidase II, ...
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-11-14
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography.
Proteins, 69, 2007
2F1A
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (2R,3R,4S)-2-({[(1S)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL
Descriptor:(2R,3R,4S)-2-({[(1S)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-11-14
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography.
Proteins, 69, 2007
2F1B
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (2R,3R,4S,5R)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)-5-METHYLPYRROLIDINE-3,4-DIOL
Descriptor:(2R,3R,4S,5R)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)-5-METHYLPYRROLIDINE-3,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-11-14
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography.
Proteins, 69, 2007
2F7O
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH MANNOSTATIN A
Descriptor:(1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-12-01
Release date:2006-07-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structural Basis of the Inhibition of Golgi alpha-Mannosidase II by Mannostatin A and the Role of the Thiomethyl Moiety in Ligand-Protein Interactions.
J.Am.Chem.Soc., 128, 2006
2F7P
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH BENZYL-MANNOSTATIN A
Descriptor:(1R,2R,3R,4S,5R)-4-(BENZYLAMINO)-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-12-01
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Structural Basis of the Inhibition of Golgi alpha-Mannosidase II by Mannostatin A and the Role of the Thiomethyl Moiety in Ligand-Protein Interactions.
J.Am.Chem.Soc., 128, 2006
2F7Q
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH AMINOCYCLOPENTITETROL
Descriptor:(1R,2R,3S,4S,5R)-5-AMINOCYCLOPENTANE-1,2,3,4-TETROL, (4S)-2-METHYL-2,4-PENTANEDIOL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-12-01
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Golgi alpha-mannosidase II complex with aminocyclopentitetrol
To be Published
2F7R
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH BENZYL-AMINOCYCLOPENTITETROL
Descriptor:(1R,2R,3S,4S,5R)-5-(BENZYLAMINO)CYCLOPENTANE-1,2,3,4-TETROL, (4S)-2-METHYL-2,4-PENTANEDIOL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kuntz, D.A., Rose, D.R.
Deposit date:2005-12-01
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Golgi alpha-mannosidase II complex with benzyl-aminocyclopentitetrol
To be Published
2FYV
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH AN AMINO-SALACINOL CARBOXYLATE ANALOG
Descriptor:(4S)-2-METHYL-2,4-PENTANEDIOL, 6-DEOXY-6-[(2R,3R,4R)-3,4-DIHYDROXY-2-(HYDROXYMETHYL)PYRROLIDIN-1-YL]-L-GULONIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kuntz, D.A, Hamlet, T., Rose, D.R.
Deposit date:2006-02-08
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Synthesis, enzymatic activity, and X-ray crystallography of an unusual class of amino acids.
Bioorg.Med.Chem., 14, 2006
2OW6
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (1R,5S,6S,7R,8S)-1-THIONIABICYCLO[4.3.0]NONAN-5,7,8-TRIOL CHLORIDE
Descriptor:(1R,5S,6S,7R,8S)-1-THIONIABICYCLO[4.3.0]NONAN-5,7,8-TRIOL, (4R)-2-METHYLPENTANE-2,4-DIOL, Alpha-mannosidase 2, ...
Authors:Kuntz, D.A.
Deposit date:2007-02-15
Release date:2008-01-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Binding of sulfonium-ion analogues of di-epi-swainsonine and 8-epi-lentiginosine to Drosophila Golgi alpha-mannosidase II: The role of water in inhibitor binding.
Proteins, 71, 2008
2OW7
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GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (1R,6S,7R,8S)-1-THIONIABICYCLO[4.3.0]NONAN-7,8-DIOL CHLORIDE
Descriptor:(1R,6S,7R,8S)-1-THIONIABICYCLO[4.3.0]NONAN-7,8-DIOL, (4R)-2-METHYLPENTANE-2,4-DIOL, Alpha-mannosidase 2, ...
Authors:Kuntz, D.A.
Deposit date:2007-02-15
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Binding of sulfonium-ion analogues of di-epi-swainsonine and 8-epi-lentiginosine to Drosophila Golgi alpha-mannosidase II: The role of water in inhibitor binding.
Proteins, 71, 2008
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