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3D9B
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BU of 3d9b by Molmil
Symmetric structure of E. coli AcrB
Descriptor: Acriflavine resistance protein B, NICKEL (II) ION
Authors:Veesler, D, Blangy, S, Cambillau, C, Sciara, G.
Deposit date:2008-05-27
Release date:2008-07-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:There is a baby in the bath water: AcrB contamination is a major problem in membrane-protein crystallization.
Acta Crystallogr.,Sect.F, 64, 2008
7RY3
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BU of 7ry3 by Molmil
Multidrug Efflux pump AdeJ with TP-6076 bound
Descriptor: (4S,4aS,5aR,12aS)-4-(diethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-8-[(2S)-pyrrolidin-2-yl]-7-(trifluoromethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, Efflux pump membrane transporter
Authors:Zhang, Z.
Deposit date:2021-08-24
Release date:2022-02-02
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii.
Mbio, 13, 2022
6CSX
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BU of 6csx by Molmil
Single particles Cryo-EM structure of AcrB D407A associated with lipid bilayer at 3.0 Angstrom
Descriptor: DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE
Authors:Qiu, W, Fu, Z, Guo, Y.
Deposit date:2018-03-21
Release date:2018-12-05
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and activity of lipid bilayer within a membrane-protein transporter.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1IWG
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BU of 1iwg by Molmil
Crystal structure of Bacterial Multidrug Efflux transporter AcrB
Descriptor: AcrB
Authors:Murakami, S, Nakashima, R, Yamashita, E, Yamaguchi, A.
Deposit date:2002-05-15
Release date:2002-10-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of bacterial multidrug efflux transporter AcrB
NATURE, 419, 2002
5T0O
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BU of 5t0o by Molmil
Crystal Structure of a membrane protein
Descriptor: CmeB
Authors:Su, C.-C, Yu, E.W.
Deposit date:2016-08-16
Release date:2017-09-06
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump.
Nat Commun, 8, 2017
6VKS
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BU of 6vks by Molmil
Cryo-electron microscopy structures of a gonococcal multidrug efflux pump illuminate a mechanism of drug recognition with ampicillin
Descriptor: (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE
Authors:Moseng, M.A, Lyu, M.
Deposit date:2020-01-22
Release date:2020-07-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance.
Mbio, 11, 2020
3KSO
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BU of 3kso by Molmil
Structure and Mechanism of the Heavy Metal Transporter CusA
Descriptor: Cation efflux system protein cusA, SILVER ION
Authors:Su, C.-C.
Deposit date:2009-11-23
Release date:2010-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (4.367 Å)
Cite:Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport.
Nature, 467, 2010
6VKT
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BU of 6vkt by Molmil
Cryo-electron microscopy structures of a gonococcal multidrug efflux pump illuminate a mechanism of erythromycin drug recognition
Descriptor: ERYTHROMYCIN A, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE
Authors:Lyu, M, Moseng, M.A.
Deposit date:2020-01-22
Release date:2020-07-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.72 Å)
Cite:Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance.
Mbio, 11, 2020
3KSS
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BU of 3kss by Molmil
Structure and Mechanism of the Heavy Metal Transporter CusA
Descriptor: COPPER (I) ION, Cation efflux system protein cusA
Authors:Su, C.-C.
Deposit date:2009-11-23
Release date:2010-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.88 Å)
Cite:Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport.
Nature, 467, 2010
7WLS
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BU of 7wls by Molmil
Crystal structure of the multidrug efflux transporter BpeB from Burkholderia pseudomallei
Descriptor: Efflux pump membrane transporter, TETRAETHYLENE GLYCOL, UNDECYL-MALTOSIDE
Authors:Kato, T, Hung, L.-W, Yamashita, E, Okada, U, Terwilliger, T.C, Murakami, S.
Deposit date:2022-01-13
Release date:2023-07-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Crystal structures of multidrug efflux transporters from Burkholderia pseudomallei suggest details of transport mechanism.
Proc.Natl.Acad.Sci.USA, 120, 2023
7WLV
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BU of 7wlv by Molmil
Crystal Structure of the Multidrug effulx transporter BpeF from Burkholderia pseudomallei.
Descriptor: DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter
Authors:Kato, T, Hung, L.-W, Yamashita, E, Okada, U, Terwilliger, T.C, Murakami, S.
Deposit date:2022-01-13
Release date:2023-07-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of multidrug efflux transporters from Burkholderia pseudomallei suggest details of transport mechanism.
Proc.Natl.Acad.Sci.USA, 120, 2023
5YIL
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BU of 5yil by Molmil
Hoisting-loop in bacterial multidrug exporter AcrB is a highly flexible hinge that enables the large motion of the subdomains
Descriptor: Multidrug efflux pump subunit AcrB
Authors:Zwama, M, Sakurai, K, Hayashi, K, Nakashima, R, Kitagawa, K, Nishino, K, Yamaguchi, A.
Deposit date:2017-10-05
Release date:2017-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains.
Front Microbiol, 8, 2017
6NZI
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BU of 6nzi by Molmil
Low resolution crystal structure of the bacterial multidrug efflux transporter AcrB in the presence of cadmium
Descriptor: CADMIUM ION, Efflux pump membrane transporter
Authors:Smith, A.T, Rosenzweig, A.C.
Deposit date:2019-02-13
Release date:2019-02-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (4.44 Å)
Cite:Low resolution crystal structure of the bacterial multidrug efflux transporter AcrB in the presence of cadmium
To Be Published
5JMN
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BU of 5jmn by Molmil
Fusidic acid bound AcrB
Descriptor: 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15-PENTAOXAHEPTADECANE, DARPin, ...
Authors:Oswald, C, Tam, H.K, Pos, K.M.
Deposit date:2016-04-29
Release date:2016-12-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB.
Nat Commun, 7, 2016
6OWS
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BU of 6ows by Molmil
Cryo-EM structure of an Acinetobacter baumannii multidrug efflux pump
Descriptor: Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE
Authors:Su, C.-C.
Deposit date:2019-05-10
Release date:2019-06-19
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump.
Mbio, 10, 2019
5LQ3
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BU of 5lq3 by Molmil
Structures and transport dynamics of the Campylobacter jejuni multidrug efflux pump CmeB
Descriptor: CmeB
Authors:Su, C.C.
Deposit date:2016-08-15
Release date:2017-08-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump.
Nat Commun, 8, 2017
8P1I
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BU of 8p1i by Molmil
Single particle cryo-EM co-structure of Klebsiella pneumoniae AcrB with the BDM91288 efflux pump inhibitor at 2.97 Angstrom resolution
Descriptor: 1,2-DIOCTANOYL-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL), 3-chloranyl-2,6-di(piperazin-4-ium-1-yl)quinoline, Efflux pump membrane transporter, ...
Authors:Boernsen, C, Mueller, R.T, Pos, K.M, Frangakis, A.S.
Deposit date:2023-05-12
Release date:2024-01-17
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae.
Embo Mol Med, 16, 2024
8PX7
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BU of 8px7 by Molmil
Structure of Bacterial Multidrug Efflux transporter AcrB, solved at wavelength 3.02 A
Descriptor: Multidrug efflux pump subunit AcrB
Authors:El Omari, K, Duman, R, Mykhaylyk, V, Orr, C, Qu, F, Beis, K, Wagner, A.
Deposit date:2023-07-22
Release date:2023-10-25
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
Commun Chem, 6, 2023
6BAJ
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BU of 6baj by Molmil
Cryo-EM structure of lipid bilayer in the native cell membrane nanoparticles of AcrB
Descriptor: DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE
Authors:Qiu, W, Fu, Z, Guo, Y.
Deposit date:2017-10-13
Release date:2018-12-19
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure and activity of lipid bilayer within a membrane-protein transporter.
Proc.Natl.Acad.Sci.USA, 115, 2018
3K0I
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BU of 3k0i by Molmil
Crystal structure of Cu(I)CusA
Descriptor: COPPER (I) ION, Cation efflux system protein cusA
Authors:Su, C.-C.
Deposit date:2009-09-24
Release date:2010-10-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (4.116 Å)
Cite:Crystal structure of CusA
To be Published
3K07
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BU of 3k07 by Molmil
Crystal structure of CusA
Descriptor: Cation efflux system protein cusA
Authors:Su, C.-C.
Deposit date:2009-09-24
Release date:2010-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.521 Å)
Cite:Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport.
Nature, 467, 2010
3NOG
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BU of 3nog by Molmil
Designed ankyrin repeat protein (DARPin) Binders to AcrB: Plasticity of the Interface
Descriptor: Acriflavine resistance protein B, Designed ankyrin repeat protein
Authors:Monroe, N, Briand, C, Gruetter, M.G.
Deposit date:2010-06-25
Release date:2011-05-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Designed ankyrin repeat protein binders for the crystallization of AcrB: Plasticity of the dominant interface
J.Struct.Biol., 174, 2011
3NOC
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BU of 3noc by Molmil
Designed ankyrin repeat protein (DARPin) binders to AcrB: Plasticity of the Interface
Descriptor: Acriflavine resistance protein B, Designed ankyrin repeat protein
Authors:Monroe, N, Briand, C, Gruetter, M.G.
Deposit date:2010-06-25
Release date:2011-05-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Designed ankyrin repeat protein binders for the crystallization of AcrB: Plasticity of the dominant interface
J.Struct.Biol., 174, 2011
6IIA
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BU of 6iia by Molmil
MexB in complex with LMNG
Descriptor: Lauryl Maltose Neopentyl Glycol, Multidrug resistance protein MexB
Authors:Nakashima, R, Sakurai, K, Nakao, K.
Deposit date:2018-10-04
Release date:2019-03-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Crystal structures of multidrug efflux pump MexB bound with high-molecular-mass compounds.
Sci Rep, 9, 2019
3W9H
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BU of 3w9h by Molmil
Structural basis for the inhibition of bacterial multidrug exporters
Descriptor: Acriflavine resistance protein B, [{2-[({[(3R)-1-{8-[(4-tert-butyl-1,3-thiazol-2-yl)carbamoyl]-4-oxo-3-[(E)-2-(1H-tetrazol-5-yl)ethenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}piperidin-3-yl]oxy}carbonyl)amino]ethyl}(dimethyl)ammonio]acetate
Authors:Sakurai, K, Nagata, C, Nakashima, R, Yamaguchi, A.
Deposit date:2013-04-04
Release date:2013-07-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural basis for the inhibition of bacterial multidrug exporters
Nature, 500, 2013

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