1AD1
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DIHYDROPTEROATE SYNTHETASE (APO FORM) FROM STAPHYLOCOCCUS AUREUS
Descriptor:DIHYDROPTEROATE SYNTHETASE, POTASSIUM ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Kostrewa, D., Oefner, C., D'Arcy, A.
Deposit date:1997-02-19
Release date:1998-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and function of the dihydropteroate synthase from Staphylococcus aureus.
J.Mol.Biol., 268, 1997
1AD4
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DIHYDROPTEROATE SYNTHETASE COMPLEXED WITH OH-CH2-PTERIN-PYROPHOSPHATE FROM STAPHYLOCOCCUS AUREUS
Descriptor:DIHYDROPTEROATE SYNTHETASE, MANGANESE (II) ION, POTASSIUM ION, ...
Authors:Oefner, C., Kostrewa, D.
Deposit date:1997-02-20
Release date:1998-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and function of the dihydropteroate synthase from Staphylococcus aureus.
J.Mol.Biol., 268, 1997
1AJ0
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI DIHYDROPTEROATE SYNTHASE
Descriptor:DIHYDROPTEROATE SYNTHASE, SULFATE ION, 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, ...
Authors:Achari, A., Somers, D.O., Champness, J.N., Bryant, P.K., Rosemond, J., Stammers, D.K.
Deposit date:1997-05-14
Release date:1998-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.
Nat.Struct.Biol., 4, 1997
1AJ2
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CRYSTAL STRUCTURE OF A BINARY COMPLEX OF E. COLI DIHYDROPTEROATE SYNTHASE
Descriptor:DIHYDROPTEROATE SYNTHASE, SULFATE ION, [7,8-DIHYDRO-PTERIN-6-YL METHANYL]-PHOSPHONOPHOSPHATE
Authors:Achari, A., Somers, D.O., Champness, J.N., Bryant, P.K., Rosemond, J., Stammers, D.K.
Deposit date:1997-05-14
Release date:1998-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.
Nat.Struct.Biol., 4, 1997
1AJZ
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STRUCTURE OF DIHYDROPTEROATE PYROPHOSPHORYLASE
Descriptor:DIHYDROPTEROATE SYNTHASE, SULFATE ION
Authors:Achari, A., Somers, D.O., Champness, J.N., Bryant, P.K., Rosemond, J., Stammers, D.K.
Deposit date:1997-05-13
Release date:1998-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.
Nat.Struct.Biol., 4, 1997
1EYE
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1.7 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF 6-HYDROXYMETHYL-7,8-DIHYDROPTEROATE SYNTHASE (DHPS) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH 6-HYDROXYMETHYLPTERIN MONOPHOSPHATE
Descriptor:DIHYDROPTEROATE SYNTHASE I, MAGNESIUM ION, PTERIN-6-YL-METHYL-MONOPHOSPHATE
Authors:Baca, A.M., Sirawaraporn, R., Turley, S., Sirawaraporn, W., Hol, W.G.J.
Deposit date:2000-05-05
Release date:2000-10-11
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action.
J.Mol.Biol., 302, 2000
1F6Y
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MAD CRYSTAL STRUCTURE ANALYSIS OF METHYLTETRAHYDROFOLATE: CORRINOID/IRON-SULFUR PROTEIN METHYLTRANSFERASE (METR)
Descriptor:5-METHYLTETRAHYDROFOLATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE
Authors:Doukov, T.I., Seravalli, J., Stezowski, J.J., Ragsdale, S.W.
Deposit date:2000-06-23
Release date:2000-08-31
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase.
Structure Fold.Des., 8, 2000
1TWS
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DIHYDROPTEROATE SYNTHETASE FROM BACILLUS ANTHRACIS
Descriptor:DHPS, Dihydropteroate synthase, SULFATE ION
Authors:Babaoglu, K., Qi, J., Lee, R.E., White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
1TWW
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DIHYDROPTEROATE SYNTHETASE, WITH BOUND SUBSTRATE ANALOGUE PTPP, FROM BACILLUS ANTHRACIS
Descriptor:DHPS, Dihydropteroate synthase, SULFATE ION, ...
Authors:Babaoglu, K., Qi, J., Lee, R.E., White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
1TWZ
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DIHYDROPTEROATE SYNTHETASE, WITH BOUND SUBSTRATE ANALOGUE PTP, FROM BACILLUS ANTHRACIS
Descriptor:DHPS, Dihydropteroate synthase, SULFATE ION, ...
Authors:Babaoglu, K., Qi, J., Lee, R.L., White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
1TX0
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DIHYDROPTEROATE SYNTHETASE, WITH BOUND PRODUCT ANALOGUE PTEROIC ACID, FROM BACILLUS ANTHRACIS
Descriptor:DHPS, Dihydropteroate synthase, SULFATE ION, ...
Authors:Babaoglu, K., Qi, J., Lee, R.E., White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
1TX2
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DIHYDROPTEROATE SYNTHETASE, WITH BOUND INHIBITOR MANIC, FROM BACILLUS ANTHRACIS
Descriptor:DHPS, Dihydropteroate synthase, SULFATE ION, ...
Authors:Babaoglu, K., Qi, J., Lee, R.E., White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
2DQW
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CRYSTAL STRUCTURE OF DIHYDROPTEROATE SYNTHASE (FOLP) FROM THERMUS THERMOPHILUS HB8
Descriptor:Dihydropteroate synthase
Authors:Bagautdinov, B., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-05-31
Release date:2006-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of Dihydropteroate Synthase (FolP) from Thermus thermophilus HB8
To be Published
2DZA
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CRYSTAL STRUCTURE OF DIHYDROPTEROATE SYNTHASE FROM THERMUS THERMOPHILUS HB8 IN COMPLEX WITH 4-AMINOBENZOATE
Descriptor:Dihydropteroate synthase, 4-AMINOBENZOIC ACID
Authors:Bagautdinov, B., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-09-27
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Dihydropteroate Synthase (FolP) from Thermus thermophilus HB8
To be Published
2DZB
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CRYSTAL STRUCTURE OF DIHYDROPTEROATE SYNTHASE FROM THERMUS THERMOPHILUS HB8 IN COMPLEX WITH 6HMPPP
Descriptor:Dihydropteroate synthase, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE
Authors:Bagautdinov, B., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-09-27
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Dihydropteroate Synthase (FolP) from Thermus thermophilus HB8
To be Published
2E7F
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5-METHYLTETRAHYDROFOLATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE COMPLEXED WITH METHYLTETRAHYDROFOLATE TO 2.2 ANGSROM RESOLUTION
Descriptor:5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase, CALCIUM ION, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID
Authors:Doukov, T.I., Drennan, C.L., Hemmi, H., Ragsdale, S.W.
Deposit date:2007-01-09
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases.
J.Biol.Chem., 282, 2007
2OGY
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ASN199ALA MUTANT OF THE 5-METHYLTETRAHYDROFOLATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE COMPLEXED WITH METHYLTETRAHYDROFOLATE TO 2.3 ANGSTROM RESOLUTION
Descriptor:5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase, CALCIUM ION, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID
Authors:Doukov, T.I., Drennan, C.L., Hemmi, H., Ragsdale, S.W.
Deposit date:2007-01-09
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases.
J.Biol.Chem., 282, 2007
2VEF
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DIHYDROPTEROATE SYNTHASE FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:DIHYDROPTEROATE SYNTHASE, PHOSPHATE ION
Authors:Derrick, J.P., Levy, C.
Deposit date:2007-10-24
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dihydropteroate Synthase from Streptococcus Pneumoniae: Structure, Ligand Recognition and Mechanism of Sulfonamide Resistance.
Biochem.J., 412, 2008
2VEG
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DIHYDROPTEROATE SYNTHASE FROM STREPTOCOCCUS PNEUMONIAE: COMPLEX WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN MONOPHOSPHATE
Descriptor:DIHYDROPTEROATE SYNTHASE, PTERIN-6-YL-METHYL-MONOPHOSPHATE, PHOSPHATE ION
Authors:Derrick, J., Levy, C.
Deposit date:2007-10-24
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dihydropteroate Synthase from Streptococcus Pneumoniae: Structure, Ligand Recognition and Mechanism of Sulfonamide Resistance.
Biochem.J., 412, 2008
2VP8
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS RV1207
Descriptor:DIHYDROPTEROATE SYNTHASE 2, 1,2-ETHANEDIOL
Authors:Gengenbacher, M., Xu, T., Niyomwattanakit, P., Spraggon, G., Dick, T.
Deposit date:2008-02-27
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Biochemical and Structural Characterization of the Putative Dihydropteroate Synthase Ortholog Rv1207 of Mycobacterium Tuberculosis.
Fems Microbiol.Lett., 287, 2008
2Y5J
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CRYSTAL STRUCTURE OF BURKHOLDERIA CENOCEPACIA DIHYDROPTEROATE SYNTHASE.
Descriptor:DIHYDROPTEROATE SYNTHASE, 1,2-ETHANEDIOL
Authors:Morgan, R.E., Batot, G.O., Dement, J.M., Rao, V.A., Eadsforth, T.C., Hunter, W.N.
Deposit date:2011-01-13
Release date:2011-01-26
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Crystal Structures of Burkholderia Cenocepacia Dihydropteroate Synthase in the Apo-Form and Complexed with the Product 7,8-Dihydropteroate.
Bmc Struct.Biol., 11, 2011
2Y5S
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CRYSTAL STRUCTURE OF BURKHOLDERIA CENOCEPACIA DIHYDROPTEROATE SYNTHASE COMPLEXED WITH 7,8-DIHYDROPTEROATE.
Descriptor:DIHYDROPTEROATE SYNTHASE, 7,8-DIHYDROPTEROATE, CHLORIDE ION, ...
Authors:Morgan, R.E., Batot, G.O., Dement, J.M., Rao, V.A., Eadsforth, T.C., Hunter, W.N.
Deposit date:2011-01-17
Release date:2011-01-26
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structures of Burkholderia Cenocepacia Dihydropteroate Synthase in the Apo-Form and Complexed with the Product 7,8-Dihydropteroate.
Bmc Struct.Biol., 11, 2011
2YCI
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METHYLTRANSFERASE NATIVE
Descriptor:5-METHYLTETRAHYDROFOLATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE, SULFATE ION
Authors:Goetzl, S., Jeoung, J.H., Hennig, S.E., Dobbek, H.
Deposit date:2011-03-16
Release date:2011-06-08
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural Basis for Electron and Methyl-Group Transfer in a Methyltransferase System Operating in the Reductive Acetyl-Coa Pathway
J.Mol.Biol., 411, 2011
2YCJ
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METHYLTRANSFERASE BOUND WITH METHYLTETRAHYDROFOLATE
Descriptor:5-METHYLTETRAHYDROFOLATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE, SULFATE ION, GLYCEROL, ...
Authors:Goetzl, S., Jeoung, J.-H., Hennig, S.E., Dobbek, H.
Deposit date:2011-03-16
Release date:2011-06-08
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural Basis for Electron and Methyl-Group Transfer in a Methyltransferase System Operating in the Reductive Acetyl-Coa Pathway
J.Mol.Biol., 411, 2011
2YCK
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METHYLTRANSFERASE BOUND WITH TETRAHYDROFOLATE
Descriptor:5-METHYLTETRAHYDROFOLATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE, SULFATE ION, GLYCEROL, ...
Authors:Goetzl, S., Jeoung, J.-H., Hennig, S.E., Dobbek, H.
Deposit date:2011-03-16
Release date:2011-06-08
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Basis for Electron and Methyl-Group Transfer in a Methyltransferase System Operating in the Reductive Acetyl-Coa Pathway
J.Mol.Biol., 411, 2011
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