5JQ9

Yersinia pestis DHPS with pterine-sulfa conjugate Compound 16

Summary for 5JQ9

Entry DOI	10.2210/pdb5jq9/pdb
Descriptor	Dihydropteroate synthase, 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	dihydropteroate synthesis, antibiotic, pterine-sulfa conjugates, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Yersinia pestis KIM D27
Total number of polymer chains	2
Total formula weight	61306.13
Authors	Wu, Y.,White, S.W. (deposition date: 2016-05-04, release date: 2016-08-10, Last modification date: 2023-09-27)
Primary citation	Zhao, Y.,Shadrick, W.R.,Wallace, M.J.,Wu, Y.,Griffith, E.C.,Qi, J.,Yun, M.K.,White, S.W.,Lee, R.E. Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents. Bioorg.Med.Chem.Lett., 26:3950-3954, 2016 Cited by PubMed: 27423480 DOI: 10.1016/j.bmcl.2016.07.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.101 Å)

Structure validation