6CLV

Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure

Summary for 6CLV

Entry DOI	10.2210/pdb6clv/pdb
Descriptor	Dihydropteroate synthase, 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide (3 entities in total)
Functional Keywords	antibiotic resistance mutations, sulfonamide resistance, antimicrobial protein
Biological source	Staphylococcus aureus
Total number of polymer chains	4
Total formula weight	130955.10
Authors	Gajewski, S.,Griffith, E.C.,Wu, Y.,White, S.W. (deposition date: 2018-03-02, release date: 2018-08-22, Last modification date: 2024-03-13)
Primary citation	Griffith, E.C.,Wallace, M.J.,Wu, Y.,Kumar, G.,Gajewski, S.,Jackson, P.,Phelps, G.A.,Zheng, Z.,Rock, C.O.,Lee, R.E.,White, S.W. The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase. Front Microbiol, 9:1369-1369, 2018 Cited by PubMed: 30065703 DOI: 10.3389/fmicb.2018.01369 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation