6CLV
Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004156 | molecular_function | dihydropteroate synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0042558 | biological_process | pteridine-containing compound metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0004156 | molecular_function | dihydropteroate synthase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0042558 | biological_process | pteridine-containing compound metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| C | 0004156 | molecular_function | dihydropteroate synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| C | 0042558 | biological_process | pteridine-containing compound metabolic process |
| C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| D | 0004156 | molecular_function | dihydropteroate synthase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| D | 0042558 | biological_process | pteridine-containing compound metabolic process |
| D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 6MB A 300 |
| Chain | Residue |
| A | ARG52 |
| A | ARG204 |
| A | ARG239 |
| A | HOH404 |
| A | ASP84 |
| A | ASN103 |
| A | MET128 |
| A | ASP167 |
| A | GLY171 |
| A | PHE172 |
| A | ALA199 |
| A | LYS203 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue 6MB B 300 |
| Chain | Residue |
| A | ASP38 |
| B | ARG52 |
| B | ASP84 |
| B | ASN103 |
| B | MET128 |
| B | ASP167 |
| B | GLY171 |
| B | PHE172 |
| B | LEU197 |
| B | ALA199 |
| B | ARG202 |
| B | LYS203 |
| B | ARG204 |
| B | ARG239 |
| B | HOH417 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue 6MB C 300 |
| Chain | Residue |
| C | SER16 |
| C | LEU17 |
| C | ASP84 |
| C | ASN103 |
| C | VAL126 |
| C | MET128 |
| C | ASP167 |
| C | GLY171 |
| C | PHE172 |
| C | ALA199 |
| C | LYS203 |
| C | ARG204 |
| C | ARG219 |
| C | ARG239 |
| D | GLU27 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9149138","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9149138","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1AD4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
