4D8A
Crystal structure of B. anthracis DHPS with compound 21
Summary for 4D8A
| Entry DOI | 10.2210/pdb4d8a/pdb |
| Related | 1TWS 4D8Z 4D9P 4DAF 4DAI 4DB7 |
| Descriptor | Dihydropteroate synthase, LYSINE, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | tim barrel, tim narrel, synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Bacillus anthracis (anthrax) |
| Total number of polymer chains | 2 |
| Total formula weight | 67241.67 |
| Authors | Hammoudeh, D.,Lee, R.E.,White, S.W. (deposition date: 2012-01-10, release date: 2012-04-04, Last modification date: 2023-09-13) |
| Primary citation | Zhao, Y.,Hammoudeh, D.,Yun, M.K.,Qi, J.,White, S.W.,Lee, R.E. Structure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased Affinity. Chemmedchem, 7:861-870, 2012 Cited by PubMed: 22416048DOI: 10.1002/cmdc.201200049 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.183 Å) |
Structure validation
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