1A76
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FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
Descriptor:FLAP ENDONUCLEASE-1 PROTEIN, MANGANESE (II) ION
Authors:Hwang, K.Y., Baek, K., Kim, H., Cho, Y.
Deposit date:1998-03-20
Release date:1999-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
1A77
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FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
Descriptor:FLAP ENDONUCLEASE-1 PROTEIN, MAGNESIUM ION
Authors:Hwang, K.Y., Baek, K., Kim, H., Cho, Y.
Deposit date:1998-03-20
Release date:1999-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
1B43
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FEN-1 FROM P. FURIOSUS
Descriptor:PROTEIN (FEN-1)
Authors:Hosfield, D.J., Mol, C.D., Shen, B., Tainer, J.A.
Deposit date:1999-01-05
Release date:2000-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Cell(Cambridge,Mass.), 95, 1998
1MC8
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CRYSTAL STRUCTURE OF FLAP ENDONUCLEASE-1 R42E MUTANT FROM PYROCOCCUS HORIKOSHII
Descriptor:Flap Endonuclease-1
Authors:Matsui, E., Musti, K.V., Abe, J., Yamazaki, K., Matsui, I., Harata, K.
Deposit date:2002-08-06
Release date:2002-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular Structure and Novel DNA Binding Sites Located in Loops of Flap Endonuclease-1 from Pyrococcus horikoshii
J.BIOL.CHEM., 277, 2002
1RXV
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CRYSTAL STRUCTURE OF A. FULGIDUS FEN-1 BOUND TO DNA
Descriptor:5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG), Flap structure-specific endonuclease
Authors:Chapados, B.R., Hosfield, D.J., Han, S., Qiu, J., Yelent, B., Shen, B., Tainer, J.A.
Deposit date:2003-12-18
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
1RXW
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CRYSTAL STRUCTURE OF A. FULGIDUS FEN-1 BOUND TO DNA
Descriptor:5'-d(*C*pG*pA*pT*pG*pC*pT*pA)-3', 5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG)-3', Flap structure-specific endonuclease
Authors:Chapados, B.R., Hosfield, D.J., Han, S., Qiu, J., Yelent, B., Shen, B., Tainer, J.A.
Deposit date:2003-12-18
Release date:2004-01-27
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
3ORY
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CRYSTAL STRUCTURE OF FLAP ENDONUCLEASE 1 FROM HYPERTHERMOPHILIC ARCHAEON DESULFUROCOCCUS AMYLOLYTICUS
Descriptor:flap endonuclease 1, PHOSPHATE ION
Authors:Mase, T., Kubota, K., Miyazono, K., Kawarabayashii, Y., Tanokura, M.
Deposit date:2010-09-08
Release date:2011-02-09
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of flap endonuclease 1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus
Acta Crystallogr.,Sect.F, 67, 2011
3QE9
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (D173A) IN COMPLEX WITH DNA (COMPLEX I)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Orans, J., McSweeney, E.A., Iyer, R.R., Hast, M.A., Hellinga, H.W., Modrich, P., Beese, L.S.
Deposit date:2011-01-20
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
3QEA
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH DNA (COMPLEX II)
Descriptor:Exonuclease 1, DNA (5'-D(P*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Orans, J., McSweeney, E.A., Iyer, R.R., Hast, M.A., Hellinga, H.W., Modrich, P., Beese, L.S.
Deposit date:2011-01-20
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
3QEB
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH DNA AND MN2+ (COMPLEX III)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Orans, J., McSweeney, E.A., Iyer, R.R., Hast, M.A., Hellinga, H.W., Modrich, P., Beese, L.S.
Deposit date:2011-01-20
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
4WA8
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METHANOPYRUS KANDLERI FEN-1 NUCLEASE
Descriptor:Flap endonuclease 1, CHLORIDE ION
Authors:Shah, S., Dunten, P., Horton, N.C.
Deposit date:2014-08-28
Release date:2014-11-12
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and specificity of FEN-1 from Methanopyrus kandleri.
Proteins, 83, 2015
5FV7
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HUMAN FEN1 IN COMPLEX WITH AN N-HYDROXYUREA COMPOUND
Descriptor:FLAP ENDONUCLEASE 1, MAGNESIUM ION, 1-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Authors:Exell, J.C., Thompson, M.J., Finger, L.D., Shaw, S.K., Abbott, W.M., McWhirter, C., Debreczeni, J.E., Jones, C.D., Nissink, J.W.M., Ward, T.A., Sioberg, C.W.L., Molina, D.M., Durant, S.T., Grasby, J.A.
Deposit date:2016-02-03
Release date:2016-08-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Cellular Active N-Hydroxyurea Fen1 Inhibitors Block Substrate Entry to the Active Site
Nat.Chem.Biol., 12, 2016
5T9J
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CRYSTAL STRUCTURE OF HUMAN GEN1 IN COMPLEX WITH HOLLIDAY JUNCTION DNA IN THE UPPER INTERFACE
Descriptor:Flap endonuclease GEN homolog 1, DNA (5'-D(*DGP*DAP*DAP*DTP*DTP*DCP*DCP*DGP*DGP*DAP*DTP*DTP*DAP*DGP*DGP*DGP*DAP*DTP*DGP*DC)-3'), DNA (5'-D(*DGP*DCP*DAP*DTP*DCP*DCP*DCP*DTP*DAP*DAP*DGP*DCP*DTP*DCP*DCP*DAP*DTP*DCP*DGP*DT)-3'), ...
Authors:Lee, S.-H., Biertumpfel, C.
Deposit date:2016-09-09
Release date:2016-09-21
Method:X-RAY DIFFRACTION (3.000127 Å)
Cite:Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.
Elife, 4, 2015
5UZV
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH 5' RECESSED-END DNA (RI)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*C)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-27
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V04
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH 5' RECESSED-END DNA (RII)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-28
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V05
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH 5' RECESSED-END DNA (RIII)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-28
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.902 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V06
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH 5' RECESSED-END DNA (RIV)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-28
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V07
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (D173A) IN COMPLEX WITH 5' RECESSED-END DNA (RV)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-28
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V08
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (D173A) IN COMPLEX WITH 5' RECESSED-END DNA (RVI)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-28
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.812 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V09
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (D225A) IN COMPLEX WITH 5' RECESSED-END DNA (RVII)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(P*AP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-28
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V0A
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (D225A) IN COMPLEX WITH 5' RECESSED-END DNA (RVIII)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(P*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-28
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V0B
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH 5' RECESSED-END DNA (RIX)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-28
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V0C
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH 5' FLAP DNA (F2I)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*A)-3'), DNA (5'-D(P*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-28
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V0D
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH 5' FLAP DNA (F2II)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*AP*CP*TP*CP*A)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-28
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V0E
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH 5' FLAP DNA (F5I)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*GP*AP*TP*AP*C)-3'), DNA (5'-D(P*CP*TP*CP*GP*TP*CP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Shi, Y., Beese, L.S.
Deposit date:2017-02-28
Release date:2017-05-24
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.744 Å)
Cite:Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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