5FV7
Human Fen1 in complex with an N-hydroxyurea compound
Summary for 5FV7
Entry DOI | 10.2210/pdb5fv7/pdb |
Descriptor | FLAP ENDONUCLEASE 1, MAGNESIUM ION, 1-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, ... (4 entities in total) |
Functional Keywords | hydrolase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 1: Nucleus, nucleolus. Isoform FENMIT: Mitochondrion : P39748 |
Total number of polymer chains | 2 |
Total formula weight | 80355.02 |
Authors | Exell, J.C.,Thompson, M.J.,Finger, L.D.,Shaw, S.K.,Abbott, W.M.,McWhirter, C.,Debreczeni, J.E.,Jones, C.D.,Nissink, J.W.M.,Ward, T.A.,Sioberg, C.W.L.,Molina, D.M.,Durant, S.T.,Grasby, J.A. (deposition date: 2016-02-03, release date: 2016-08-17, Last modification date: 2024-05-08) |
Primary citation | Exell, J.C.,Thompson, M.J.,Finger, L.D.,Shaw, S.K.,Abbott, W.M.,Mcwhirter, C.,Debreczeni, J.E.,Jones, C.D.,Nissink, J.W.M.,Ward, T.A.,Sioberg, C.W.L.,Molina, D.M.,Durant, S.T.,Grasby, J.A. Cellular Active N-Hydroxyurea Fen1 Inhibitors Block Substrate Entry to the Active Site Nat.Chem.Biol., 12:815-, 2016 Cited by PubMed: 27526030DOI: 10.1038/NCHEMBIO.2148 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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