5FV7

Human Fen1 in complex with an N-hydroxyurea compound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	FLAP ENDONUCLEASE 1	polymer	353	39796.6	2	UniProt (P39748) Pfam (PF00752) Pfam (PF00867)	HOMO SAPIENS (HUMAN)	FEN-1, DNASE IV, FLAP STRUCTURE-SPECIFIC ENDONUCLEASE 1, MATURATION FACTOR 1, MF1, HFEN-1
2	C, D, F, G (A, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
3	E, H (A, B)	1-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione	non-polymer		332.3	2	Chemie (R3Z)
4	I (A)	water	water		18.0	1	Chemie (HOH)

Sequence modifications

A, B: 1 - 336 (UniProt: P39748)

PDB	External Database	Details
Leu 337	-	expression tag
Glu 338	-	expression tag
Val 339	-	expression tag
Leu 340	-	expression tag
Phe 341	-	expression tag
Gln 342	-	expression tag
Gly 343	-	expression tag
Pro 344	-	expression tag
Gly 345	-	expression tag
Gly 346	-	expression tag
Gly 347	-	expression tag
His 348	-	expression tag
His 349	-	expression tag
His 350	-	expression tag
His 351	-	expression tag
His 352	-	expression tag
His 353	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	79593.1
Non-Polymers*	Number of molecules	6
	Total formula weight	761.9
All*	Total formula weight	80355.0

*Water molecules are not included.