1YDN
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CRYSTAL STRUCTURE OF THE HMG-COA LYASE FROM BRUCELLA MELITENSIS, NORTHEAST STRUCTURAL GENOMICS TARGET LR35.
Descriptor:HYDROXYMETHYLGLUTARYL-COA LYASE, CALCIUM ION
Authors:Forouhar, F., Abashidze, M., Hussain, M., Vorobiev, S.M., Xiao, R., Ciano, M., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-12-24
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds.
J.Biol.Chem., 281, 2006
1YDO
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CRYSTAL STRUCTURE OF THE BACILLIS SUBTILIS HMG-COA LYASE, NORTHEAST STRUCTURAL GENOMICS TARGET SR181.
Descriptor:HMG-CoA Lyase, IODIDE ION
Authors:Forouhar, F., Hussain, M., Edstrom, W., Vorobiev, S.M., Xiao, R., Ciano, M., Shih, L., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-12-24
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds.
J.Biol.Chem., 281, 2006
2CW6
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CRYSTAL STRUCTURE OF HUMAN HMG-COA LYASE: INSIGHTS INTO CATALYSIS AND THE MOLECULAR BASIS FOR HYDROXYMETHYLGLUTARIC ACIDURIA
Descriptor:Hydroxymethylglutaryl-CoA lyase, mitochondrial, MAGNESIUM ION, ...
Authors:Fu, Z., Runquist, J.A., Hunt, J.F., Miziorko, H.M., Kim, J.-J.P.
Deposit date:2005-06-17
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria
J.Biol.Chem., 281, 2006
2FTP
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CRYSTAL STRUCTURE OF HYDROXYMETHYLGLUTARYL-COA LYASE FROM PSEUDOMONAS AERUGINOSA
Descriptor:hydroxymethylglutaryl-CoA lyase, SODIUM ION, GLYCEROL
Authors:Xiao, T., Evdokimova, E., Liu, Y., Kudritska, M., Savchenko, A., Pai, E.F., Edwards, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2006-01-24
Release date:2006-03-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa
To be Published
2NX9
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CRYSTAL STRUCTURE OF THE CARBOXYLTRANSFERASE DOMAIN OF THE OXALOACETATE DECARBOXYLASE NA+ PUMP FROM VIBRIO CHOLERAE
Descriptor:Oxaloacetate decarboxylase 2, subunit alpha, ZINC ION
Authors:Studer, R., Dimroth, P.
Deposit date:2006-11-17
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of the Carboxyltransferase Domain of the Oxaloacetate Decarboxylase Na(+) Pump from Vibrio cholerae.
J.Mol.Biol., 367, 2007
2ZTJ
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CRYSTAL STRUCTURE OF HOMOCITRATE SYNTHASE FROM THERMUS THERMOPHILUS COMPLEXED WITH ALPHA-KETOGLUTARATE
Descriptor:Homocitrate synthase, 2-OXOGLUTARIC ACID, COPPER (II) ION
Authors:Okada, T., Tomita, T., Kuzuyama, T., Nishiyama, M.
Deposit date:2008-10-06
Release date:2009-10-13
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from Thermus thermophilus
J.Biol.Chem., 285, 2010
2ZTK
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CRYSTAL STRUCTURE OF HOMOCITRATE SYNTHASE FROM THERMUS THERMOPHILUS COMPLEXED WITH HOMOCITRATE
Descriptor:Homocitrate synthase, 3-HYDROXY-3-CARBOXY-ADIPIC ACID, COPPER (II) ION
Authors:Okada, T., Tomita, T., Kuzuyama, T., Nishiyama, M.
Deposit date:2008-10-06
Release date:2009-10-13
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from Thermus thermophilus
J.Biol.Chem., 285, 2010
2ZYF
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CRYSTAL STRUCTURE OF HOMOCITRATE SYNTHASE FROM THERMUS THERMOPHILUS COMPLEXED WITH MAGNESUIM ION AND ALPHA-KETOGLUTARATE
Descriptor:Homocitrate synthase, 2-OXOGLUTARIC ACID, MAGNESIUM ION
Authors:Okada, T., Tomita, T., Kuzuyama, T., Nishiyama, M.
Deposit date:2009-01-20
Release date:2009-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from thermus thermophilus
J.Biol.Chem., 2009
3A9I
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CRYSTAL STRUCTURE OF HOMOCITRATE SYNTHASE FROM THERMUS THERMOPHILUS COMPLEXED WITH LYS
Descriptor:Homocitrate synthase, COBALT (II) ION, LYSINE
Authors:Okada, T., Tomita, T., Kuzuyama, T., Nishiyama, M.
Deposit date:2009-10-28
Release date:2009-12-22
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from Thermus thermophilus
J.Biol.Chem., 285, 2010
3BLE
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LICMS IN COMPLEXED WITH MALONATE
Descriptor:Citramalate synthase from Leptospira interrogans, ZINC ION, MALONATE ION
Authors:Zhang, P., Ma, J.
Deposit date:2007-12-11
Release date:2008-11-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans
Biochem.J., 415, 2008
3BLF
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LICMS IN COMPLEXED WITH PYRUVATE
Descriptor:Citramalate synthase from Leptospira interrogans, ZINC ION, PYRUVIC ACID
Authors:Zhang, P., Ma, J.
Deposit date:2007-12-11
Release date:2008-11-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans
Biochem.J., 415, 2008
3BLI
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LICMS IN COMPLEXED WITH PYRUVATE AND ACETYL-COA
Descriptor:Citramalate synthase from Leptospira interrogans, ZINC ION, ACETYL COENZYME *A, ...
Authors:Zhang, P., Ma, J.
Deposit date:2007-12-11
Release date:2008-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans
Biochem.J., 415, 2008
3EEG
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CRYSTAL STRUCTURE OF A 2-ISOPROPYLMALATE SYNTHASE FROM CYTOPHAGA HUTCHINSONII
Descriptor:2-isopropylmalate synthase
Authors:Sugadev, R., Burley, S.K., Swaminathan, S., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-09-04
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Crystal structure of a 2-isopropylmalate synthase from Cytophaga hutchinsonii
To be Published
3EWB
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF PUTATIVE 2-ISOPROPYLMALATE SYNTHASE FROM LISTERIA MONOCYTOGENES
Descriptor:2-isopropylmalate synthase
Authors:Ramagopal, U.A., Toro, R., Gilmore, M., Hu, S., Maletic, M., Rodgers, L., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-10-14
Release date:2008-12-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of N-terminal domain of putative 2-isopropylmalate synthase from Listeria monocytogenes.
To be Published
3HPX
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LEUA ACTIVE SITE DOMAIN 1-425 (TRUNCATION MUTANT DELTA:426-644)
Descriptor:2-isopropylmalate synthase, NICKEL (II) ION, GLYCEROL
Authors:Koon, N., Squire, C.J., Baker, E.N.
Deposit date:2009-06-05
Release date:2010-05-19
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Biochemistry, 51, 2012
3IVS
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HOMOCITRATE SYNTHASE LYS4
Descriptor:Homocitrate synthase, mitochondrial, COBALT (II) ION, ...
Authors:Bulfer, S.L., Scott, E.M., Couture, J.-F., Pillus, L., Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3IVT
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HOMOCITRATE SYNTHASE LYS4 BOUND TO 2-OG
Descriptor:Homocitrate synthase, mitochondrial, ZINC ION, ...
Authors:Bulfer, S.L., Scott, E.M., Couture, J.-F., Pillus, L., Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3IVU
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HOMOCITRATE SYNTHASE LYS4 BOUND TO 2-OG
Descriptor:Homocitrate synthase, mitochondrial, COBALT (II) ION, ...
Authors:Bulfer, S.L., Scott, E.M., Couture, J.-F., Pillus, L., Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3MI3
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HOMOCITRATE SYNTHASE LYS4 BOUND TO LYSINE
Descriptor:Homocitrate synthase, mitochondrial, LYSINE, ...
Authors:Bulfer, S.L., Scott, E.M., Pillus, L., Trievel, R.C.
Deposit date:2010-04-09
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Basis for L-lysine Feedback Inhibition of Homocitrate Synthase
J.Biol.Chem., 285, 2010
3MP3
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CRYSTAL STRUCTURE OF HUMAN LYASE IN COMPLEX WITH INHIBITOR HG-COA
Descriptor:Hydroxymethylglutaryl-CoA lyase, 3-HYDROXYPENTANEDIOIC ACID, MAGNESIUM ION, ...
Authors:Fu, Z., Runquist, J.A., Montgomery, C., Miziorko, H.M., Kim, J.-J.P.
Deposit date:2010-04-24
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
3MP4
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CRYSTAL STRUCTURE OF HUMAN LYASE R41M MUTANT
Descriptor:Hydroxymethylglutaryl-CoA lyase
Authors:Fu, Z., Runquist, J.A., Montgomery, C., Miziorko, H.M., Kim, J.-J.P.
Deposit date:2010-04-24
Release date:2010-06-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
3MP5
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CRYSTAL STRUCTURE OF HUMAN LYASE R41M IN COMPLEX WITH HMG-COA
Descriptor:Hydroxymethylglutaryl-CoA lyase, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, MAGNESIUM ION
Authors:Fu, Z., Runquist, J.A., Montgomery, C., Miziorko, H.M., Kim, J.-J.P.
Deposit date:2010-04-24
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
3RMJ
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CRYSTAL STRUCTURE OF TRUNCATED ALPHA-ISOPROPYLMALATE SYNTHASE FROM NEISSERIA MENINGITIDIS
Descriptor:2-isopropylmalate synthase, MANGANESE (II) ION, MAGNESIUM ION, ...
Authors:Huisman, F.H.A., Baker, H.M., Koon, N., Baker, E.N., Parker, E.J.
Deposit date:2011-04-20
Release date:2012-03-14
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Biochemistry, 51, 2012
3U6W
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TRUNCATED M. TUBERCULOSIS LEUA (1-425) COMPLEXED WITH KIV
Descriptor:2-isopropylmalate synthase, MANGANESE (II) ION, 3-METHYL-2-OXOBUTANOIC ACID, ...
Authors:Koon, N., Baker, E.N., Squire, C.J.
Deposit date:2011-10-13
Release date:2012-03-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding.
Biochemistry, 51, 2012
4OV4
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ISOPROPYLMALATE SYNTHASE BINDING WITH KETOISOVALERATE
Descriptor:2-isopropylmalate synthase, ZINC ION, 3-METHYL-2-OXOBUTANOIC ACID
Authors:Zhang, Z., Wu, J., Wang, C., Zhang, P.
Deposit date:2014-02-20
Release date:2014-08-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subdomain II of alpha-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition.
J.Biol.Chem., 289, 2014
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