6A6M
 
 | | Crystal structure of an outward-open nucleotide-bound state of the eukaryotic ABC multidrug transporter CmABCB1 | | Descriptor: | ATP-binding cassette, sub-family B, member 1, ... | | Authors: | Kato, H, Nakatsu, T, Kodan, A. | | Deposit date: | 2018-06-28 | | Release date: | 2019-02-20 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1.
Nat Commun, 10, 2019
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7DQV
 | | Crystal structure of a CmABCB1 mutant | | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, MAGNESIUM ION, NITRATE ION, ... | | Authors: | Matsuoka, K, Nakatsu, T, Kato, H. | | Deposit date: | 2020-12-24 | | Release date: | 2021-03-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The crystal structure of the CmABCB1 G132V mutant, which favors the outward-facing state, reveals the mechanism of the pivotal joint between TM1 and TM3.
Protein Sci., 30, 2021
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7FC9
 | | Crystal structure of CmABCB1 in lipidic mesophase revealed by LCP-SFX | | Descriptor: | ACETATE ION, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Pan, D, Oyama, R, Sato, T, Nakane, T, Mizunuma, R, Matsuoka, K, Joti, Y, Tono, K, Nango, E, Iwata, S, Nakatsu, T, Kato, H. | | Deposit date: | 2021-07-14 | | Release date: | 2022-02-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX.
Iucrj, 9, 2022
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4MRS
 | | Structure of a bacterial Atm1-family ABC transporter | | Descriptor: | ABC transporter related protein, LAURYL DIMETHYLAMINE-N-OXIDE, OXIDIZED GLUTATHIONE DISULFIDE, ... | | Authors: | Lee, J.Y, Yang, J.G, Zhitnitsky, D, Lewinson, O, Rees, D.C. | | Deposit date: | 2013-09-17 | | Release date: | 2014-03-19 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural basis for heavy metal detoxification by an Atm1-type ABC exporter.
Science, 343, 2014
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3WMG
 | | Crystal structure of an inward-facing eukaryotic ABC multidrug transporter G277V/A278V/A279V mutant in complex with an cyclic peptide inhibitor, aCAP | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ATP-binding cassette, sub-family B, ... | | Authors: | Kodan, A, Yamaguchi, T, Nakatsu, T, Sakiyama, K, Hipolito, C.J, Fujioka, A, Hirokane, R, Ikeguchi, K, Watanabe, B, Hirtake, J, Kimura, Y, Suga, H, Ueda, K, Kato, H. | | Deposit date: | 2013-11-18 | | Release date: | 2014-04-30 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.
Proc.Natl.Acad.Sci.USA, 111, 2014
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8Y6H
 | | P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent | | Descriptor: | ATP-dependent translocase ABCB1,mNeonGreen, UIC2 Fab heavy chain, UIC2 Fab light chain, ... | | Authors: | Hamaguchi-Suzuki, N, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Anzai, N, Senda, T, Murata, T. | | Deposit date: | 2024-02-02 | | Release date: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (2.49 Å) | | Cite: | Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules.
Biochem.Biophys.Res.Commun., 709, 2024
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4MRV
 | | Structure of a bacterial Atm1-family ABC transporter | | Descriptor: | ABC transporter related protein, LAURYL DIMETHYLAMINE-N-OXIDE, PHOSPHATE ION, ... | | Authors: | Lee, J.Y, Yang, J.G, Zhitnitsky, D, Lewinson, O, Rees, D.C. | | Deposit date: | 2013-09-17 | | Release date: | 2014-03-19 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for heavy metal detoxification by an Atm1-type ABC exporter.
Science, 343, 2014
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4MRP
 | | Structure of a bacterial Atm1-family ABC transporter | | Descriptor: | ABC transporter related protein, GLUTATHIONE, LAURYL DIMETHYLAMINE-N-OXIDE, ... | | Authors: | Lee, J.Y, Yang, J.G, Zhitnitsky, D, Lewinson, O, Rees, D.C. | | Deposit date: | 2013-09-17 | | Release date: | 2014-03-19 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for heavy metal detoxification by an Atm1-type ABC exporter.
Science, 343, 2014
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4MRN
 | | Structure of a bacterial Atm1-family ABC transporter | | Descriptor: | ABC transporter related protein, LAURYL DIMETHYLAMINE-N-OXIDE, PHOSPHATE ION | | Authors: | Lee, J.Y, Yang, J.G, Zhitnitsky, D, Lewinson, O, Rees, D.C. | | Deposit date: | 2013-09-17 | | Release date: | 2014-03-19 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for heavy metal detoxification by an Atm1-type ABC exporter.
Science, 343, 2014
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4Q4H
 | | TM287/288 in its apo state | | Descriptor: | ABC transporter, Uncharacterized ABC transporter ATP-binding protein TM_0288 | | Authors: | Hohl, M, Gruetter, M.G, Seeger, M.A. | | Deposit date: | 2014-04-14 | | Release date: | 2014-07-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.527 Å) | | Cite: | Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.
Proc.Natl.Acad.Sci.USA, 111, 2014
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8Y6I
 | | P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, ATP-dependent translocase ABCB1,mNeonGreen, CHOLESTEROL, ... | | Authors: | Hamaguchi-Suzuki, N, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Anzai, N, Senda, T, Murata, T. | | Deposit date: | 2024-02-02 | | Release date: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules.
Biochem.Biophys.Res.Commun., 709, 2024
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7ZK4
 | | The ABCB1 L335C mutant (mABCB1) in the outward facing state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent translocase ABCB1, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Parey, K, Januliene, D, Gewering, T, Moeller, A. | | Deposit date: | 2022-04-12 | | Release date: | 2023-04-26 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Tracing the substrate translocation mechanism in P-glycoprotein.
Elife, 12, 2024
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7ZK5
 | | ABCB1 L335C mutant (mABCB1) in the outward facing state bound to AAC | | Descriptor: | (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent translocase ABCB1, ... | | Authors: | Parey, K, Januliene, D, Gewering, T, Moeller, A. | | Deposit date: | 2022-04-12 | | Release date: | 2023-04-26 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Tracing the substrate translocation mechanism in P-glycoprotein.
Elife, 12, 2024
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3WMF
 | | Crystal structure of an inward-facing eukaryotic ABC multitrug transporter G277V/A278V/A279V mutant | | Descriptor: | ATP-binding cassette, sub-family B, member 1, ... | | Authors: | Kodan, A, Yamaguchi, T, Nakatsu, T, Kato, H. | | Deposit date: | 2013-11-18 | | Release date: | 2014-03-19 | | Last modified: | 2022-08-24 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4Q4A
 | | Improved model of AMP-PNP bound TM287/288 | | Descriptor: | ABC transporter, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Hohl, M, Gruetter, M.G, Seeger, M.A. | | Deposit date: | 2014-04-14 | | Release date: | 2014-07-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.
Proc.Natl.Acad.Sci.USA, 111, 2014
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8UBR
 | | Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with CFTRinh-172 and ATP/Mg | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Young, P.G, Fiedorczuk, K, Chen, J. | | Deposit date: | 2023-09-24 | | Release date: | 2024-02-21 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural basis for CFTR inhibition by CFTR inh -172.
Proc.Natl.Acad.Sci.USA, 121, 2024
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6TEJ
 | | Structure of apo IrtAB devoid SID in complex with sybody Syb_NL5 | | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, Drug ABC transporter ATP-binding protein, NICKEL (II) ION, ... | | Authors: | Gonda, I, Arnold, F.M, Hutter, C.A.J, Weber, M.S, Seeger, M.A, Hurlimann, L.M. | | Deposit date: | 2019-11-12 | | Release date: | 2020-04-01 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The ABC exporter IrtAB imports and reduces mycobacterial siderophores.
Nature, 580, 2020
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7SVD
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8SX7
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4PL0
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5MKK
 | | Crystal structure of the heterodimeric ABC transporter TmrAB, a homolog of the antigen translocation complex TAP | | Descriptor: | Multidrug resistance ABC transporter ATP-binding and permease protein, SULFATE ION | | Authors: | Noell, A, Thomas, C, Tomasiak, T.M, Olieric, V, Wang, M, Diederichs, K, Stroud, R.M, Pos, K.M, Tampe, R. | | Deposit date: | 2016-12-05 | | Release date: | 2017-01-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7ZDT
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3WME
 | | Crystal structure of an inward-facing eukaryotic ABC multidrug transporter | | Descriptor: | ATP-binding cassette, sub-family B, member 1, ... | | Authors: | Kodan, A, Yamaguchi, T, Nakatsu, T, Kato, H. | | Deposit date: | 2013-11-18 | | Release date: | 2014-03-19 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.751 Å) | | Cite: | Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.
Proc.Natl.Acad.Sci.USA, 111, 2014
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7ZDG
 | | IF(heme/confined) conformation of CydDC (Dataset-5) | | Descriptor: | ATP-binding/permease protein CydC, ATP-binding/permease protein CydD, HEME B/C | | Authors: | Wu, D, Safarian, S. | | Deposit date: | 2022-03-29 | | Release date: | 2023-04-19 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Dissecting the conformational complexity and mechanism of a bacterial heme transporter.
Nat.Chem.Biol., 19, 2023
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8EIO
 | | The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445), lumacaftor (VX-809) and ATP/Mg | | Descriptor: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | | Authors: | Fiedorczuk, K, Chen, J. | | Deposit date: | 2022-09-15 | | Release date: | 2022-10-19 | | Last modified: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
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