3WMG

Crystal structure of an inward-facing eukaryotic ABC multidrug transporter G277V/A278V/A279V mutant in complex with an cyclic peptide inhibitor, aCAP

Summary for 3WMG

Entry DOI	10.2210/pdb3wmg/pdb
Related	3WME 3WMF
Related PRD ID	PRD_001229
Descriptor	ATP-binding cassette, sub-family B, member 1, anti-CmABCB1 peptide, DECYL-BETA-D-MALTOPYRANOSIDE, ... (5 entities in total)
Functional Keywords	rec fold, multi drug transporter, macrocyclic peptide, transport protein-inhibitor complex, transport protein/inhibitor
Biological source	Cyanidioschyzon merolae More
Total number of polymer chains	2
Total formula weight	72066.43
Authors	Kodan, A.,Yamaguchi, T.,Nakatsu, T.,Sakiyama, K.,Hipolito, C.J.,Fujioka, A.,Hirokane, R.,Ikeguchi, K.,Watanabe, B.,Hirtake, J.,Kimura, Y.,Suga, H.,Ueda, K.,Kato, H. (deposition date: 2013-11-18, release date: 2014-04-30, Last modification date: 2017-11-22)
Primary citation	Kodan, A.,Yamaguchi, T.,Nakatsu, T.,Sakiyama, K.,Hipolito, C.J.,Fujioka, A.,Hirokane, R.,Ikeguchi, K.,Watanabe, B.,Hiratake, J.,Kimura, Y.,Suga, H.,Ueda, K.,Kato, H. Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog. Proc.Natl.Acad.Sci.USA, 111:4049-4054, 2014 Cited by PubMed: 24591620 DOI: 10.1073/pnas.1321562111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation