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3WMG

Crystal structure of an inward-facing eukaryotic ABC multidrug transporter G277V/A278V/A279V mutant in complex with an cyclic peptide inhibitor, aCAP

Functional Information from GO Data
ChainGOidnamespacecontents
A0005524molecular_functionATP binding
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0055085biological_processtransmembrane transport
A0140359molecular_functionABC-type transporter activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE DMU A 801
ChainResidue
ATRP114
ATHR119
AVAL122
AMET456
ADMU804

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE DMU A 802
ChainResidue
AGLY179
AALA183

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE DMU A 804
ChainResidue
ADMU801
AARG107
ATRP114

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE TRS A 805
ChainResidue
AGLY471
AMET631
AALA632
ASER633
AVAL636
AASP652

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE DMU B 101
ChainResidue
BPHE8
BLEU14

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR CHAIN B OF ANTI-CMABCB1 PEPTIDE
ChainResidue
AARG144
ALYS162
ATYR163
AILE257
AASN375
AASN378
BDMU101

Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAI
ChainResidueDetails
ALEU585-ILE599

229380

PDB entries from 2024-12-25

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