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4U5X
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BU of 4u5x by Molmil
Structure of plant small GTPase OsRac1 complexed with the non-hydrolyzable GTP analog GMPPNP
Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Ohki, I, Kosami, K, Fujiwara, T, Nakagawa, A, Shimamoto, K, Kojima, C.
Deposit date:2014-07-25
Release date:2014-08-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Crystal Structure of the Plant Small GTPase OsRac1 Reveals Its Mode of Binding to NADPH Oxidase
J.Biol.Chem., 289, 2014
6L6O
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BU of 6l6o by Molmil
Crystal structure of stabilized Rab5a GTPase domain from Leishmania donovani
Descriptor: ACETATE ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Arora, A, Zohib, M, Biswal, B.K, Maheshwari, D, Pal, R.K.
Deposit date:2019-10-29
Release date:2020-11-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the GDP-bound GTPase domain of Rab5a from Leishmania donovani.
Acta Crystallogr.,Sect.F, 76, 2020
8ALK
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BU of 8alk by Molmil
Structure of the Legionella phosphocholine hydrolase Lem3 in complex with its substrate Rab1
Descriptor: 2-[[[5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxyethyl-[3-(2-chloranylethanoylamino)propyl]-dimethyl-azanium, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Kaspers, M.S, Pett, C, Hedberg, C, Itzen, A, Pogenberg, V.
Deposit date:2022-08-01
Release date:2023-04-12
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b.
Nat Commun, 14, 2023
9O0R
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BU of 9o0r by Molmil
Crystal structure of wild-type KRAS (GDP-bound) in complex with MRTX849 (adagrasib)
Descriptor: ACETATE ION, Adagrasib, GTPase KRas, ...
Authors:Chan, A.H, Ashraf, M, Simanshu, D.K.
Deposit date:2025-04-03
Release date:2025-06-25
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints.
J.Biol.Chem., 2025
9O0S
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BU of 9o0s by Molmil
Crystal structure of KRAS-Q61R mutant, GMPPNP-bound
Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Chan, A.H, Davies, D, Abendroth, J, Simanshu, D.K.
Deposit date:2025-04-03
Release date:2025-06-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints.
J.Biol.Chem., 2025
3K9L
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BU of 3k9l by Molmil
Allosteric modulation of H-Ras GTPase
Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
Authors:Fetics, S, Young, M, Buhrman, G, Mattos, C.
Deposit date:2009-10-15
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Allosteric modulation of H-Ras GTPase
To be Published
8BLR
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BU of 8blr by Molmil
G13D mutant of KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation
Descriptor: GTPase KRas, N-terminally processed, GUANOSINE-5'-DIPHOSPHATE
Authors:Moche, M, Jungholm, O, Strandback, E, Ampah-Korsah, H, Nyman, T, Orwar, O.
Deposit date:2022-11-10
Release date:2024-05-22
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody.
Sci Rep, 14, 2024
3SBE
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BU of 3sbe by Molmil
Crystal structure of RAC1 P29S mutant
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2011-06-03
Release date:2012-07-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
3SBD
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BU of 3sbd by Molmil
Crystal structure of RAC1 P29S mutant
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2011-06-03
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
3SFV
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BU of 3sfv by Molmil
Crystal structure of the GDP-bound Rab1a S25N mutant in complex with the coiled-coil domain of LidA from Legionella pneumophila
Descriptor: GUANOSINE-5'-DIPHOSPHATE, LidA protein, substrate of the Dot/Icm system, ...
Authors:Yin, K, Lu, D, Zhu, D, Zhang, H, Li, B, Xu, S, Gu, L.
Deposit date:2011-06-14
Release date:2012-04-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State
Plos Pathog., 8, 2012
5XR7
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BU of 5xr7 by Molmil
Crystal structure of RabA1a (Q72K) in complex with GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein RABA1a
Authors:Yun, J.S, Chang, J.H.
Deposit date:2017-06-07
Release date:2018-06-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure and subcellular localization of RabA1a from Arabidopsis thaliana
To Be Published
8ZNY
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BU of 8zny by Molmil
Small GTPase RhoA Y42C mutant in complex with GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA
Authors:Wu, H, Jiang, H.
Deposit date:2024-05-28
Release date:2025-06-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Magnesium Ion Locking RhoA Mutant in Highly Dynamic Cycling Conformations
To Be Published
2HXS
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BU of 2hxs by Molmil
Crystal Structure of Rab28A GTPase in the Inactive (GDP-3'P-Bound) Form
Descriptor: GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-28
Authors:Lee, S.H, Li, Y, Dominguez, R.
Deposit date:2006-08-03
Release date:2007-08-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:The Crystal Structure of Rab28 GTPase in Active and Inactive Forms
To be Published
5XCO
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BU of 5xco by Molmil
Crystal structure of human K-Ras G12D Mutant in complex with GDP and Cyclic Inhibitory Peptide
Descriptor: 1,2-ETHANEDIOL, ACE-ARG-ARG-ARG-ARG-CYS-PRO-LEU-TYR-ILE-SER-TYR-ASP-PRO-VAL-CYS-ARG-ARG-ARG-ARG-NH2, GTPase KRas, ...
Authors:Sogabe, S, Miwa, M.
Deposit date:2017-03-23
Release date:2017-05-24
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d
ACS Med Chem Lett, 8, 2017
8ZO0
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BU of 8zo0 by Molmil
Samll GTPase RhoA Y42C mutant in complex with GTP analogue
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Transforming protein RhoA
Authors:Jiang, H, Wu, H.
Deposit date:2024-05-28
Release date:2025-06-04
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Magnesium Ion Locking RhoA Mutant in Highly Dynamic Cycling Conformations
To Be Published
5XC3
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BU of 5xc3 by Molmil
Crystal structure of Acanthamoeba polyphaga mimivirus Rab GTPase in complex with GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Probable Rab-related GTPase
Authors:Ku, B, You, J.A, Kim, S.J.
Deposit date:2017-03-22
Release date:2017-10-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase
Arch. Virol., 162, 2017
4UJ5
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BU of 4uj5 by Molmil
Crystal structure of human Rab11-Rabin8-FIP3
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAB-3A-INTERACTING PROTEIN, ...
Authors:Vetter, M, Lorentzen, E.
Deposit date:2015-04-08
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Structure of Rab11-Fip3-Rabin8 Reveals Simultaneous Binding of Fip3 and Rabin8 Effectors to Rab11.
Nat.Struct.Mol.Biol., 22, 2015
5XR6
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BU of 5xr6 by Molmil
Crystal structure of RabA1a in complex with GppNHp
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein RABA1a
Authors:Yun, J.S, Chang, J.H.
Deposit date:2017-06-07
Release date:2018-06-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure and subcellular localization of RabA1a from Arabidopsis thaliana
To Be Published
2IL1
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BU of 2il1 by Molmil
Crystal structure of a predicted human GTPase in complex with GDP
Descriptor: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2006-10-02
Release date:2006-10-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a predicted human GTPase in complex with GDP
To be Published
2IC5
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BU of 2ic5 by Molmil
Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Ugochukwu, E, Yang, X, Zao, Y, Elkins, J, Gileadi, C, Burgess, N, Colebrook, S, Gileadi, O, Fedorov, O, Bunkoczi, G, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, von Delft, F, Doyle, D, Structural Genomics Consortium (SGC)
Deposit date:2006-09-12
Release date:2006-10-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.
To be Published
2IEZ
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BU of 2iez by Molmil
Crystal Structure of mouse Rab27b bound to GDP in monoclinic space group
Descriptor: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-27B
Authors:Chavas, L.M.G, Torii, S, Kamikubo, H, Kawasaki, M, Ihara, K, Kato, R, Kataoka, M, Izumi, T, Wakatsuki, S.
Deposit date:2006-09-19
Release date:2007-05-01
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the small GTPase Rab27b shows an unexpected swapped dimer
Acta Crystallogr.,Sect.D, 63, 2007
1KMQ
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BU of 1kmq by Molmil
Crystal Structure of a Constitutively Activated RhoA Mutant (Q63L)
Descriptor: 1,4-DIETHYLENE DIOXIDE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Longenecker, K, Read, P, Lin, S.-K, Somlyo, A.P, Nakamoto, R.K, Derewenda, Z.S.
Deposit date:2001-12-17
Release date:2003-05-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution.
Acta Crystallogr.,Sect.D, 59, 2003
6T5V
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BU of 6t5v by Molmil
KRasG12C ligand complex
Descriptor: 1-[4-[6-chloranyl-7-(5-methyl-1~{H}-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl]propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Phillips, C.
Deposit date:2019-10-17
Release date:2020-02-19
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C.
J.Med.Chem., 63, 2020
6TAM
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BU of 6tam by Molmil
X-RAY STRUCTURE OF HUMAN K-RAS G12C IN COMPLEX WITH COVALENT ISOQUINOLINONE INHIBITOR (COMPOUND 3)
Descriptor: 7-[2,4-bis(fluoranyl)phenyl]-3-[(3~{R})-1-propanoylpyrrolidin-3-yl]-4~{H}-isoquinolin-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Friberg, A, Nguyen, D.
Deposit date:2019-10-30
Release date:2020-04-08
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C.
Chemmedchem, 15, 2020
6TAN
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BU of 6tan by Molmil
X-RAY STRUCTURE OF HUMAN K-RAS G12C IN COMPLEX WITH COVALENT ISOQUINOLINONE INHIBITOR (COMPOUND 17)
Descriptor: 7-(2-fluoranyl-6-oxidanyl-phenyl)-3-[(3~{R})-1-propanoylpyrrolidin-3-yl]-4~{H}-2,6-naphthyridin-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Hillig, R.C, Eis, K, Badock, V.
Deposit date:2019-10-30
Release date:2020-04-08
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C.
Chemmedchem, 15, 2020

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