6TAM
X-RAY STRUCTURE OF HUMAN K-RAS G12C IN COMPLEX WITH COVALENT ISOQUINOLINONE INHIBITOR (COMPOUND 3)
Summary for 6TAM
Entry DOI | 10.2210/pdb6tam/pdb |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | kras, inhibitor, covalent binding, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20202.69 |
Authors | Friberg, A.,Nguyen, D. (deposition date: 2019-10-30, release date: 2020-04-08, Last modification date: 2020-06-03) |
Primary citation | Mortier, J.,Friberg, A.,Badock, V.,Moosmayer, D.,Schroeder, J.,Steigemann, P.,Siegel, F.,Gradl, S.,Bauser, M.,Hillig, R.C.,Briem, H.,Eis, K.,Bader, B.,Nguyen, D.,Christ, C.D. Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C. Chemmedchem, 15:827-832, 2020 Cited by PubMed: 32237114DOI: 10.1002/cmdc.201900727 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.64 Å) |
Structure validation
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