8BLR

G13D mutant of KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation

Summary for 8BLR

• Entry DOI: 10.2210/pdb8blr/pdb
• Descriptor: GTPase KRas, N-terminally processed, GUANOSINE-5'-DIPHOSPHATE (3 entities in total)
• Functional Keywords: kras, colorectal cancer, ras signalling, cancer stem cells, ras-driven metastasis, kras structure, kras mutations, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 19906.11

Authors

Moche, M.,Jungholm, O.,Strandback, E.,Ampah-Korsah, H.,Nyman, T.,Orwar, O. (deposition date: 2022-11-10, release date: 2024-05-22)

• Primary citation: Moche, M.,Jungholm, O.,Strandback, E.,Nyman, T.,Orwar, O.,Ampah-Korsah, H.; The 1.4 A crystal structure of K-Ras4A mutant G13D in open conformation; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.4 Å)