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8TCE
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BU of 8tce by Molmil
Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3353871
Descriptor: (2S)-3-phenyl-2-[(3R)-pyrrolidin-3-yl]propanoic acid, Apolipoprotein(a)
Authors:Hendle, J, Weichert, K, Sauder, J.M.
Deposit date:2023-06-30
Release date:2024-05-08
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nature, 629, 2024
6OSN
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BU of 6osn by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: ACETATE ION, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-01
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.083 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSH
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BU of 6osh by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: Antibody Light chain variable region, Antibody heavy chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-01
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.117 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
8V9B
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BU of 8v9b by Molmil
Lipoprotein(a) Kringle IV domain 7 - Lp(a) KIV7 in complex with LY3441732
Descriptor: (2S,2'S)-3,3'-[carbonylbis(azanediyl-3,1-phenylene)]bis{2-[(3R)-pyrrolidin-1-ium-3-yl]propanoate}, Apolipoprotein(a), MAGNESIUM ION, ...
Authors:Hendle, J, Weichert, K, Sauder, J.M.
Deposit date:2023-12-07
Release date:2024-05-08
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nature, 629, 2024
6OSV
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BU of 6osv by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: Antibody heavy chain variable region, Antibody light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-02
Release date:2020-04-01
Last modified:2020-05-13
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
7TNG
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BU of 7tng by Molmil
Kringle domain of human Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1)
Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1
Authors:Guarino, S.R, Di Bello, A, Palamini, M, Forneris, F.
Deposit date:2022-01-21
Release date:2022-05-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1)
Acta Crystallogr.,Sect.F, 78, 2022
1I71
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BU of 1i71 by Molmil
HIGH RESOLUTION CRYSTAL STRUCTURE OF APOLIPOPROTEIN(A) KRINGLE IV TYPE 7: INSIGHTS INTO LIGAND BINDING
Descriptor: APOLIPOPROTEIN(A), SULFATE ION
Authors:Ye, Q, Rahman, M.N, Koschinsky, M.L, Jia, Z.
Deposit date:2001-03-07
Release date:2001-06-13
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:High-resolution crystal structure of apolipoprotein(a) kringle IV type 7: insights into ligand binding.
Protein Sci., 10, 2001
4BVC
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BU of 4bvc by Molmil
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
Descriptor: 3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE, APOLIPOPROTEIN(A), CHLORIDE ION, ...
Authors:Sandmark, J, Althage, M, Andersson, G.M.K, Antonsson, T, Blaho, S, Bodin, C, Bostrom, J, Chen, Y, Dahlen, A, Eriksson, P.O, Evertsson, E, Fex, T, Fjellstrom, O, Gustafsson, D, Hallberg, C, Hicks, R, Jarkvist, E, Johansson, C, Kalies, I, Kang, D, Svalstedt Karlsson, B, Kartberg, F, Legnehed, A, Lindqvist, A.M, Martinsson, S.A, Moberg, A, Petersson, A.U, Ridderstrom, M, Thelin, A, Tigerstrom, A, Vinblad, J, Xu, B, Knecht, W.
Deposit date:2013-06-25
Release date:2014-07-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
6BA5
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BU of 6ba5 by Molmil
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain Heavy chain, antibody R11, ...
Authors:Park, H, Rader, C.
Deposit date:2017-10-12
Release date:2018-06-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6RX7
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BU of 6rx7 by Molmil
Structure of the KIV type 2 (KIV-2) domain of lipoprotein (a)
Descriptor: Apolipoprotein(a), GLYCEROL, SULFATE ION
Authors:Santonastaso, A, Maggi, M, Scotti, C.
Deposit date:2019-06-07
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:High resolution structure of human apolipoprotein (a) kringle IV type 2: beyond the lysine binding site.
J.Lipid Res., 61, 2020
5HPG
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BU of 5hpg by Molmil
STRUCTURE AND LIGAND DETERMINANTS OF THE RECOMBINANT KRINGLE 5 DOMAIN OF HUMAN PLASMINOGEN
Descriptor: PLASMINOGEN
Authors:Tulinsky, A, Mochalkin, I, Castellino, F.J.
Deposit date:1997-09-19
Release date:1998-03-25
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen.
Biochemistry, 37, 1998
1KRN
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BU of 1krn by Molmil
STRUCTURE OF KRINGLE 4 AT 4C TEMPERATURE AND 1.67 ANGSTROMS RESOLUTION
Descriptor: PLASMINOGEN, SULFATE ION
Authors:Stec, B, Teeter, M.M, Whitlow, M, Yamano, A.
Deposit date:1995-06-21
Release date:1997-01-11
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structure of human plasminogen kringle 4 at 1.68 a and 277 K. A possible structural role of disordered residues.
Acta Crystallogr.,Sect.D, 53, 1997
4BVD
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BU of 4bvd by Molmil
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
Descriptor: 5-chloro-2-fluoro-N-[1-(4-piperidyl)pyrazol-4-yl]benzenesulfonamide, APOLIPOPROTEIN(A), CHLORIDE ION
Authors:Sandmark, J, Althage, M, Andersson, G.M.K, Antonsson, T, Blaho, S, Bodin, C, Bostrom, J, Chen, Y, Dahlen, A, Eriksson, P.O, Evertsson, E, Fex, T, Fjellstrom, O, Gustafsson, D, Hallberg, C, Hicks, R, Jarkvist, E, Johansson, C, Kalies, I, Kang, D, Svalstedt Karlsson, B, Kartberg, F, Legnehed, A, Lindqvist, A.M, Martinsson, S.A, Moberg, A, Petersson, A.U, Ridderstrom, M, Thelin, A, Tigerstrom, A, Vinblad, J, Xu, B, Knecht, W.
Deposit date:2013-06-25
Release date:2014-07-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
7OCM
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BU of 7ocm by Molmil
K1K1H6, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hepatocyte growth factor alpha chain,Hepatocyte growth factor alpha chain
Authors:de Jonge, H, de Nola, G, Gherardi, E.
Deposit date:2021-04-27
Release date:2021-07-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist.
Life Sci Alliance, 5, 2022
6OG4
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BU of 6og4 by Molmil
plasminogen binding group A streptococcal M protein
Descriptor: Plasminogen, Plasminogen-binding group A streptococcal M-like protein PAM, SULFATE ION
Authors:Law, R.H.P, Quek, A.J, Whisstock, J.C, Caradoc-Davies, T.T.
Deposit date:2019-04-01
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding.
J.Mol.Biol., 431, 2019
4BV7
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BU of 4bv7 by Molmil
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
Descriptor: 3-(4-piperidyl)propanoic acid, ACETATE ION, APOLIPOPROTEIN(A)
Authors:Sandmark, J, Althage, M, Andersson, G.M.K, Antonsson, T, Blaho, S, Bodin, C, Bostrom, J, Chen, Y, Dahlen, A, Eriksson, P.O, Evertsson, E, Fex, T, Fjellstrom, O, Gustafsson, D, Hallberg, C, Hicks, R, Jarkvist, E, Johansson, C, Kalies, I, Kang, D, Svalstedt Karlsson, B, Kartberg, F, Legnehed, A, Lindqvist, A.M, Martinsson, S.A, Moberg, A, Petersson, A.U, Ridderstrom, M, Thelin, A, Tigerstrom, A, Vinblad, J, Xu, B, Knecht, W.
Deposit date:2013-06-25
Release date:2014-07-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
7ME4
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BU of 7me4 by Molmil
Structure of the extracellular WNT-binding module in Drosophila Ror2/Nrk
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITOLEIC ACID, Tyrosine-protein kinase transmembrane receptor Ror2
Authors:Mendrola, J.M, Shi, F, Perry, K, Stayrook, S.E, Lemmon, M.A.
Deposit date:2021-04-06
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.
Cell Rep, 37, 2021
1KI0
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BU of 1ki0 by Molmil
The X-ray Structure of Human Angiostatin
Descriptor: ANGIOSTATIN, BICINE
Authors:Abad, M.C, Arni, R.K, Grella, D.K, Castellino, F.J, Tulinsky, A, Geiger, J.H.
Deposit date:2001-12-02
Release date:2002-05-29
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin.
J.Mol.Biol., 318, 2002
4CIK
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BU of 4cik by Molmil
plasminogen kringle 1 in complex with inhibitor
Descriptor: 5-[(2R,4S)-2-(phenylmethyl)piperidin-4-yl]-1,2-oxazol-3-one, PLASMINOGEN
Authors:Xue, Y, Johansson, C, Cheng, L, Pettersen, D, Gustafsson, D.
Deposit date:2013-12-10
Release date:2014-06-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Discovery of the Fibrinolysis Inhibitor Azd6564, Acting Via Interference of a Protein-Protein Interaction.
Acs Med.Chem.Lett., 5, 2014
7OCL
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BU of 7ocl by Molmil
K1K1, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic
Descriptor: Hepatocyte growth factor alpha chain,Hepatocyte growth factor alpha chain
Authors:de Jonge, H, de Nola, G, Gherardi, E.
Deposit date:2021-04-27
Release date:2021-07-21
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist.
Life Sci Alliance, 5, 2022
3KIV
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BU of 3kiv by Molmil
RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)
Descriptor: 6-AMINOHEXANOIC ACID, APOLIPOPROTEIN
Authors:Mochalkin, I, Tulinsky, A, Scanu, A.
Deposit date:1998-09-08
Release date:1999-05-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance.
Biochemistry, 38, 1999
4BVV
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BU of 4bvv by Molmil
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
Descriptor: 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, APOLIPOPROTEIN(A), SULFATE ION
Authors:Sandmark, J, Althage, M, Andersson, G.M.K, Antonsson, T, Blaho, S, Bodin, C, Bostrom, J, Chen, Y, Dahlen, A, Eriksson, P.O, Evertsson, E, Fex, T, Fjellstrom, O, Gustafsson, D, Hallberg, C, Hicks, R, Jarkvist, E, Johansson, C, Kalies, I, Kang, D, Svalstedt Karlsson, B, Kartberg, F, Legnehed, A, Lindqvist, A.M, Martinsson, S.A, Moberg, A, Petersson, A.U, Ridderstrom, M, Thelin, A, Tigerstrom, A, Vinblad, J, Xu, B, Knecht, W.
Deposit date:2013-06-28
Release date:2014-07-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
2QJ2
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BU of 2qj2 by Molmil
A Mechanistic Basis for Converting a Receptor Tyrosine Kinase Agonist to an Antagonist
Descriptor: Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D, Daugherty, J, Gao, C.-F, Xe, Q, Miranti, C, Gherardi, E, Vande Woude, G, Xu, H.E.
Deposit date:2007-07-06
Release date:2007-09-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Proc.Natl.Acad.Sci.Usa, 104, 2007
3K65
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BU of 3k65 by Molmil
Crystal Structure of Prethombin-2/Fragment-2 Complex
Descriptor: 1,4-BUTANEDIOL, Prothrombin
Authors:Adams, T.E, Huntington, J.A.
Deposit date:2009-10-08
Release date:2010-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural transitions during prothrombin activation: On the importance of fragment 2.
Biochimie, 122, 2016
3SP8
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BU of 3sp8 by Molmil
Crystal structure of NK2 in complex with fractionated Heparin DP10
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Recacha, R, Mulloy, B, Gherardi, E.
Deposit date:2011-07-01
Release date:2012-07-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of NK2 in complex with fractionated Heparin DP10
TO BE PUBLISHED

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