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5KAZ
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BU of 5kaz by Molmil
Human SH2D1B structure
Descriptor: SH2 domain-containing protein 1B, SULFATE ION
Authors:Taha, M, Nezerwa, E, Nam, H.-J.
Deposit date:2016-06-02
Release date:2017-04-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The X-ray Crystallographic Structure of Human EAT2 (SH2D1B).
Protein Pept. Lett., 23, 2016
2QMS
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BU of 2qms by Molmil
Crystal structure of a signaling molecule
Descriptor: Growth factor receptor-bound protein 7, SULFATE ION
Authors:Porter, C.J, Wilce, M.C, Wilce, J.A.
Deposit date:2007-07-16
Release date:2008-07-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.
Bmc Struct.Biol., 7, 2007
1JYR
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BU of 1jyr by Molmil
Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide
Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, peptide: PSpYVNVQN
Authors:Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A.
Deposit date:2001-09-13
Release date:2002-03-13
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
J.Mol.Biol., 315, 2002
2GE9
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BU of 2ge9 by Molmil
Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase
Descriptor: Tyrosine-protein kinase BTK
Authors:Cheng, J.-W, Huang, K.-C.
Deposit date:2006-03-18
Release date:2006-10-24
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase
J.Biomol.Nmr, 36, 2006
7CIO
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BU of 7cio by Molmil
Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase
Descriptor: Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha
Authors:Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M.
Deposit date:2020-07-08
Release date:2020-12-09
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
Mol.Immunol., 131, 2021
6ICG
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BU of 6icg by Molmil
Grb2 SH2 domain in phosphopeptide free form
Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, SULFATE ION
Authors:Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M.
Deposit date:2018-09-06
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structural and functional properties of Grb2 SH2 dimer in CD28 binding.
Biophys Physicobio., 16, 2019
3WA4
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BU of 3wa4 by Molmil
Grb2 SH2 domain/CD28-derived peptide complex
Descriptor: ACETIC ACID, CADMIUM ION, Growth factor receptor-bound protein 2, ...
Authors:Higo, K, Oda, M, Ito, N.
Deposit date:2013-04-23
Release date:2014-02-26
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28
Plos One, 8, 2013
1WQU
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BU of 1wqu by Molmil
Solution structure of the human FES SH2 domain
Descriptor: Proto-oncogene tyrosine-protein kinase FES/FPS
Authors:Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-10-02
Release date:2005-06-14
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes
J.Biomol.NMR, 31, 2005
5DF6
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BU of 5df6 by Molmil
Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide
Descriptor: Tyrosine-protein phosphatase non-receptor type 11, UNKNOWN ATOM OR ION, txnip
Authors:Dong, A, Li, W, Tempel, W, Liu, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2015-08-26
Release date:2015-09-23
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
Biochem.J., 473, 2016
2YSX
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BU of 2ysx by Molmil
Solution structure of the human SHIP SH2 domain
Descriptor: Signaling inositol polyphosphate phosphatase SHIP II
Authors:Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-04
Release date:2008-04-08
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the human SHIP SH2 domain
To be Published
6SM5
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BU of 6sm5 by Molmil
MbC/SHP1-C-SH2 complex
Descriptor: MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6
Authors:Mann, G, Hantschel, O.
Deposit date:2019-08-21
Release date:2021-01-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:MbC/SHP1-C-SH2 complex
To Be Published
2YU7
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BU of 2yu7 by Molmil
Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
Descriptor: Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A
Authors:Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-05
Release date:2008-04-15
Last modified:2024-11-13
Method:SOLUTION NMR
Cite:Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
To be Published
7RNV
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BU of 7rnv by Molmil
SH2 domain of guanine nucleotide exchange factor Vav2 in complex with an actin peptide with phosphorylated tyrosine 53
Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ...
Authors:Dai, S, Horton, J.R, Cheng, X.
Deposit date:2021-07-29
Release date:2021-08-11
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin
To Be Published
7RNS
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BU of 7rns by Molmil
nSH2 domain of p85-alpha subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53
Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ...
Authors:Dai, S, Horton, J.R, Cheng, X.
Deposit date:2021-07-29
Release date:2021-08-11
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin
To Be Published
7RNU
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BU of 7rnu by Molmil
nSH2 domain of p85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53
Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ...
Authors:Dai, S, Horton, J.R, Cheng, X.
Deposit date:2021-07-29
Release date:2021-08-11
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin
To Be Published
8ATK
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BU of 8atk by Molmil
The SH2 domain of mouse SH2B1
Descriptor: SH2B adapter protein 1
Authors:Fowler, N.J, Williamson, M.P, Albalwi, M.F.
Deposit date:2022-08-23
Release date:2023-05-24
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: The SH2 domain of SH2B1.
Structure, 31, 2023
1CWD
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BU of 1cwd by Molmil
HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE
Descriptor: (PHOSPHONOMETHYL)PHENYLALANINE-CONTAINING PEPTIDE PRO-GLU-GLY-ASP-PM3-GLU-GLU-VAL-LEU, P56LCK TYROSINE KINASE
Authors:Mikol, V.
Deposit date:1995-09-06
Release date:1996-12-07
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
J.Mol.Biol., 246, 1995
1CSZ
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BU of 1csz by Molmil
SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR
Descriptor: ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE
Authors:Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C.
Deposit date:1995-10-03
Release date:1996-11-08
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Structure, 3, 1995
1CSY
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BU of 1csy by Molmil
SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR
Descriptor: ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE
Authors:Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C.
Deposit date:1995-10-03
Release date:1996-11-08
Last modified:2024-11-13
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Structure, 3, 1995
1CWE
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BU of 1cwe by Molmil
HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE
Descriptor: P56LCK TYROSINE KINASE, PHOSPHOPEPTIDE ACQ-PMP-GLU-GLU-ILE-PRO
Authors:Mikol, V.
Deposit date:1995-09-06
Release date:1996-12-07
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
J.Mol.Biol., 246, 1995
7SA7
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BU of 7sa7 by Molmil
Crystal structure of the apo SH2 domains of Syk
Descriptor: Tyrosine-protein kinase SYK
Authors:Hobbs, H.T, Badroos, J, Gee, C.L, Kuriyan, J.
Deposit date:2021-09-22
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein Sci., 30, 2021
3S8N
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BU of 3s8n by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide
Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ...
Authors:Clements, J.H, Stephen, F.M.
Deposit date:2011-05-29
Release date:2011-11-02
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area.
J.Am.Chem.Soc., 133, 2011
3S9K
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BU of 3s9k by Molmil
Crystal structure of the Itk SH2 domain.
Descriptor: CITRIC ACID, Tyrosine-protein kinase ITK/TSK
Authors:Joseph, R.E, Ginder, N.D, Hoy, J.A, Nix, J.C, Fulton, B.D, Honzatko, R.B, Andreotti, A.H.
Deposit date:2011-06-01
Release date:2012-02-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.354 Å)
Cite:Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.
Acta Crystallogr.,Sect.F, 68, 2012
3S8L
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BU of 3s8l by Molmil
Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing Hydrophobic Surface Area
Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ...
Authors:Clements, J.H, Stephen, F.M.
Deposit date:2011-05-29
Release date:2011-11-02
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area.
J.Am.Chem.Soc., 133, 2011
3S8O
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BU of 3s8o by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide
Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, SODIUM ION, ...
Authors:Clements, J.H, Stephen, F.M.
Deposit date:2011-05-29
Release date:2011-11-02
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area.
J.Am.Chem.Soc., 133, 2011

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