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2E5Q
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Solution structure of the TUDOR domain of PHD finger protein 19, isoform b [Homo sapiens]
Descriptor: PHD finger protein 19
Authors:Dang, W, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-12-22
Release date:2007-06-26
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the TUDOR domain of PHD finger protein 19, isoform b [Homo sapiens]
To be Published
2M0O
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BU of 2m0o by Molmil
The solution structure of human PHF1 in complex with H3K36me3
Descriptor: H3K36me3 peptide, PHD finger protein 1
Authors:Song, J, Patel, D.J.
Deposit date:2012-10-30
Release date:2013-01-16
Last modified:2013-02-27
Method:SOLUTION NMR
Cite:An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting.
Mol.Cell, 49, 2013
2M16
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P75/LEDGF PWWP Domain
Descriptor: PC4 and SFRS1-interacting protein
Authors:Crowe, B.L, Foster, M.P.
Deposit date:2012-11-18
Release date:2013-02-27
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes.
Nucleic Acids Res., 41, 2013
2MSR
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BU of 2msr by Molmil
Solution structure of LEDGF/p75 IBD in complex with MLL1 peptide (140-160)
Descriptor: Histone-lysine N-methyltransferase 2A, PC4 and SFRS1-interacting protein
Authors:Cermakova, K, Tesina, P, Demeulemeester, J, El Ashkar, S, Mereau, H, Schwaller, J, Rezacova, P, Veverka, V, De Rijck, J.
Deposit date:2014-08-05
Release date:2014-08-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Validation and Structural Characterization of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia.
Cancer Res., 74, 2014
2N3A
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Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404)
Descriptor: PC4 and SFRS1-interacting protein, Pogo transposable element with ZNF domain
Authors:Tesina, P, Cermakova, K, Horejsi, M, Prochazkova, K, Fabry, M, Sharma, S, Christ, F, Demeulemeester, J, Debyser, Z, De Rijck, J, Veverka, V, Rezacova, P.
Deposit date:2015-05-26
Release date:2015-08-19
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.
Nat Commun, 6, 2015
2OQ6
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Crystal structure of JMJD2A complexed with histone H3 peptide trimethylated at Lys9
Descriptor: JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ...
Authors:Pilka, E.S, Ng, S.S, Kavanagh, K.L, McDonough, M.A, Savitsky, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-01-31
Release date:2007-03-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Nature, 448, 2007
2OQ7
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The crystal structure of JMJD2A complexed with Ni and N-oxalylglycine
Descriptor: JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ...
Authors:Kavanagh, K.L, Ng, S.S, Pilka, E, McDonough, M.A, Savitsky, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-01-31
Release date:2007-03-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Nature, 448, 2007
2OS2
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Crystal structure of JMJD2A complexed with histone H3 peptide trimethylated at Lys36
Descriptor: JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ...
Authors:Kavanagh, K.L, Ng, S.S, Pilka, E, McDonough, M.A, Savitsky, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-02-05
Release date:2007-03-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Nature, 448, 2007
2OT7
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Crystal structure of JMJD2A complexed with histone H3 peptide monomethylated at Lys9
Descriptor: JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ...
Authors:Kavanagh, K.L, Ng, S.S, Pilka, E, McDonough, M.A, Savitsky, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-02-07
Release date:2007-03-13
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.135 Å)
Cite:Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Nature, 448, 2007
2OX0
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Crystal structure of JMJD2A complexed with histone H3 peptide dimethylated at Lys9
Descriptor: CHLORIDE ION, JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, ...
Authors:Pilka, E.S, Ng, S.S, Kavanagh, K.L, McDonough, M.A, Savitsky, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-02-19
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Nature, 448, 2007
2Q8C
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Crystal structure of JMJD2A in ternary complex with an histone H3K9me3 peptide and 2-oxoglutarate
Descriptor: 2-OXOGLUTARIC ACID, HISTONE 3 PEPTIDE, JmjC domain-containing histone demethylation protein 3A, ...
Authors:Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
2Q8D
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BU of 2q8d by Molmil
Crystal structure of JMJ2D2A in ternary complex with histone H3-K36me2 and succinate
Descriptor: HISTONE 3 peptide, JmjC domain-containing histone demethylation protein 3A, NICKEL (II) ION, ...
Authors:Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
2Q8E
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Specificity and Mechanism of JMJD2A, a Trimethyllysine-Specific Histone Demethylase
Descriptor: JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ...
Authors:Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
2X35
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Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.
Descriptor: PEREGRIN
Authors:Vezzoli, A, Bonadies, N, Allen, M.D, Freund, S.M.V, Santiveri, C.M, Kvinlaug, B, Huntly, B.J.P, Gottgens, B, Bycroft, M.
Deposit date:2010-01-21
Release date:2010-02-02
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Basis of Histone H3K36Me3 Recognition by the Pwwp Domain of Brpf1.
Nat.Struct.Mol.Biol., 17, 2010
2X4W
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Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.
Descriptor: FORMIC ACID, HISTONE H3.2, PEREGRIN
Authors:Vezzoli, A, Bonadies, N, Allen, M.D, Freund, S.M.V, Santiveri, C.M, Kvinlaug, B, Huntly, B.J.P, Gottgens, B, Bycroft, M.
Deposit date:2010-02-02
Release date:2010-04-21
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular Basis of Histone H3K36Me3 Recognition by the Pwwp Domain of Brpf1.
Nat.Struct.Mol.Biol., 17, 2010
2X4X
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Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.
Descriptor: HISTONE H3.2, PEREGRIN, SULFATE ION
Authors:Vezzoli, A, Bonadies, N, Allen, M.D, Freund, S.M.V, Santiveri, C.M, Kvinlaug, B, Huntly, B.J.P, Gottgens, B, Bycroft, M.
Deposit date:2010-02-02
Release date:2010-04-21
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular Basis of Histone H3K36Me3 Recognition by the Pwwp Domain of Brpf1.
Nat.Struct.Mol.Biol., 17, 2010
2X4Y
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Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.
Descriptor: HISTONE H3.2, PEREGRIN, SULFATE ION
Authors:Vezzoli, A, Bonadies, N, Allen, M.D, Freund, S.M.V, Santiveri, C.M, Kvinlaug, B, Huntly, B.J.P, Gottgens, B, Bycroft, M.
Deposit date:2010-02-02
Release date:2010-04-21
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular Basis of Histone H3K36Me3 Recognition by the Pwwp Domain of Brpf1.
Nat.Struct.Mol.Biol., 17, 2010
2YB8
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Crystal structure of Nurf55 in complex with Su(z)12
Descriptor: POLYCOMB PROTEIN SU(Z)12, PROBABLE HISTONE-BINDING PROTEIN CAF1, SULFATE ION
Authors:Schmitges, F.W, Prusty, A.B, Faty, M, Stutzer, A, Lingaraju, G.M, Aiwazian, J, Sack, R, Hess, D, Li, L, Zhou, S, Bunker, R.D, Wirth, U, Bouwmeester, T, Bauer, A, Ly-Hartig, N, Zhao, K, Chan, H, Gu, J, Gut, H, Fischle, W, Muller, J, Thoma, N.H.
Deposit date:2011-03-02
Release date:2011-05-18
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Histone Methylation by Prc2 is Inhibited by Active Chromatin Marks.
Mol.Cell, 42, 2011
2YBA
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Crystal structure of Nurf55 in complex with histone H3
Descriptor: HISTONE H3, PROBABLE HISTONE-BINDING PROTEIN CAF1
Authors:Schmitges, F.W, Prusty, A.B, Faty, M, Stutzer, A, Lingaraju, G.M, Aiwazian, J, Sack, R, Hess, D, Li, L, Zhou, S, Bunker, R.D, Wirth, U, Bouwmeester, T, Bauer, A, Ly-Hartig, N, Zhao, K, Chan, H, Gu, J, Gut, H, Fischle, W, Muller, J, Thoma, N.H.
Deposit date:2011-03-02
Release date:2011-05-11
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Histone Methylation by Prc2 is Inhibited by Active Chromatin Marks
Mol.Cell, 42, 2011
2YBK
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JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE
Descriptor: (2R)-2-hydroxypentanedioic acid, CHLORIDE ION, LYSINE-SPECIFIC DEMETHYLASE 4A, ...
Authors:Chowdhury, R, McDonough, M.A, Schofield, C.J.
Deposit date:2011-03-08
Release date:2011-04-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YBP
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JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)
Descriptor: (2R)-2-hydroxypentanedioic acid, GLYCEROL, HISTONE H3.1T, ...
Authors:Chowdhury, R, McDonough, M.A, Schofield, C.J.
Deposit date:2011-03-09
Release date:2011-03-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
2YBS
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JMJD2A COMPLEXED WITH S-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)
Descriptor: (2S)-2-HYDROXYPENTANEDIOIC ACID, GLYCEROL, HISTONE H3.1T, ...
Authors:Chowdhury, R, Schofield, C.J.
Deposit date:2011-03-10
Release date:2011-03-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep., 12, 2011
3MO8
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PWWP Domain of Human Bromodomain and PHD finger-containing protein 1 In Complex with Trimethylated H3K36 Peptide
Descriptor: Histone H3.2 TRIMETHYLATED H3K36 PEPTIDE, Peregrin
Authors:Lam, R, Zeng, H, Ni, S, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2010-04-22
Release date:2010-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural and Histone Binding Ability Characterizations of Human PWWP Domains.
Plos One, 6, 2011
4A7J
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Symmetric Dimethylation of H3 Arginine 2 is a Novel Histone Mark that Supports Euchromatin Maintenance
Descriptor: HISTONE H3.1T, WD REPEAT-CONTAINING PROTEIN 5
Authors:Migliori, V, Muller, J, Phalke, S, Low, D, Bezzi, M, ChuenMok, W, Gunaratne, J, Capasso, P, Bassi, C, Cecatiello, V, DeMarco, A, Blackstock, W, Kuznetsov, V, Amati, B, Mapelli, M, Guccione, E.
Deposit date:2011-11-14
Release date:2012-01-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Symmetric Dimethylation of H3R2 is a Newly Identified Histone Mark that Supports Euchromatin Maintenance
Nat.Struct.Mol.Biol., 19, 2012
4AI9
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JMJD2A Complexed with Daminozide
Descriptor: CHLORIDE ION, DAMINOZIDE, GLYCEROL, ...
Authors:Chowdhury, R, Schofield, C.J.
Deposit date:2012-02-08
Release date:2012-10-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
J. Med. Chem., 55, 2012

 

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