2MSR
Solution structure of LEDGF/p75 IBD in complex with MLL1 peptide (140-160)
Summary for 2MSR
| Entry DOI | 10.2210/pdb2msr/pdb |
| NMR Information | BMRB: 25130 |
| Descriptor | Histone-lysine N-methyltransferase 2A, PC4 and SFRS1-interacting protein (2 entities in total) |
| Functional Keywords | ledgf/p75, mll, mixed lineage leukemia, protein binding |
| Biological source | Homo sapiens (human) More |
| Cellular location | Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164 Nucleus: O75475 |
| Total number of polymer chains | 2 |
| Total formula weight | 12532.30 |
| Authors | Cermakova, K.,Tesina, P.,Demeulemeester, J.,El Ashkar, S.,Mereau, H.,Schwaller, J.,Rezacova, P.,Veverka, V.,De Rijck, J. (deposition date: 2014-08-05, release date: 2014-08-20, Last modification date: 2023-06-14) |
| Primary citation | Cermakova, K.,Tesina, P.,Demeulemeester, J.,El Ashkar, S.,Mereau, H.,Schwaller, J.,Rezacova, P.,Veverka, V.,De Rijck, J. Validation and Structural Characterization of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia. Cancer Res., 74:5139-5151, 2014 Cited by PubMed: 25082813DOI: 10.1158/0008-5472.CAN-13-3602 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
Download full validation report
