5BT3
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CRYSTAL STRUCTURE OF EP300 BROMODOMAIN IN COMPLEX WITH SGC-CBP30 CHEMICAL PROBE
Descriptor:Histone acetyltransferase p300, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, ISOPROPYL ALCOHOL
Authors:Tallant, C., Hay, D., Krojer, T., Nunez-Alonso, G., Picaud, S., Newman, J.A., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2015-06-02
Release date:2015-07-01
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Crystal structure of EP300 bromodomain in complex with a 3,5-dimethylisoxazol ligand
To Be Published
6V8B
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CRYSTAL STRUCTURE OF THE P300 ACETYLTRANSFERASE DOMAIN WITH ACCOA COMPETITIVE INHIBITOR 1
Descriptor:Histone acetyltransferase p300, 4-(2-{[(1R)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino}ethyl)benzene-1-sulfonamide, CHLORIDE ION, ...
Authors:Gardberg, A.S.
Deposit date:2019-12-10
Release date:2020-04-01
Last modified:2020-06-17
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.
Chemmedchem, 15, 2020
6V8K
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CRYSTAL STRUCTURE OF THE P300 ACETYLTRANSFERASE DOMAIN WITH PEPTIDE-COMPETITIVE INHIBITOR 2
Descriptor:Histone acetyltransferase p300, COENZYME A, 1-(2-methyl-1H-indol-3-yl)-2-[(2R)-2-methylpiperidin-1-yl]ethan-1-one, ...
Authors:Gardberg, A.S.
Deposit date:2019-12-11
Release date:2020-04-01
Last modified:2020-06-17
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.
Chemmedchem, 15, 2020
6V8N
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CRYSTAL STRUCTURE OF THE P300 ACETYLTRANSFERASE DOMAIN WITH ACCOA COMPETITIVE INHIBITOR 17
Descriptor:Histone acetyltransferase p300, SULFATE ION, CHLORIDE ION, ...
Authors:Gardberg, A.S., Wilson, J.E.
Deposit date:2019-12-11
Release date:2020-04-01
Last modified:2020-06-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.
Chemmedchem, 15, 2020
6V90
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CRYSTAL STRUCTURE OF THE P300 ACETYLTRANSFERASE DOMAIN WITH ACCOA COMPETITIVE INHIBITOR 12
Descriptor:Histone acetyltransferase p300, (2R)-2-{[2-(4-cyanophenyl)ethyl]amino}-N-[5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl]-2-phenylacetamide, SULFATE ION, ...
Authors:Gardberg, A.S.
Deposit date:2019-12-12
Release date:2020-04-01
Last modified:2020-06-17
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.
Chemmedchem, 15, 2020
5NU5
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CRYSTAL STRUCTURE OF THE HUMAN BROMODOMAIN OF EP300 BOUND TO THE INHIBITOR XDM-CBP
Descriptor:Histone acetyltransferase p300, ~{N}-[[2,8-bis(oxidanyl)naphthalen-1-yl]methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide, 1,2-ETHANEDIOL
Authors:Huegle, M., Wohlwend, D.
Deposit date:2017-04-28
Release date:2017-08-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Angew. Chem. Int. Ed. Engl., 56, 2017
3I3J
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN EP300
Descriptor:Histone acetyltransferase p300, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Filippakopoulos, P., Picaud, S., Phillips, C., Pike, A.C.W., Muniz, J., Roos, A., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-06-30
Release date:2009-07-28
Last modified:2013-05-08
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
5LPK
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN EP300 BOUND TO THE INHIBITOR XDM1
Descriptor:Histone acetyltransferase p300, ~{N}-[(3-chlorophenyl)methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide, SULFATE ION, ...
Authors:Huegle, M., Wohlwend, D.
Deposit date:2016-08-13
Release date:2017-08-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Angew. Chem. Int. Ed. Engl., 56, 2017
5LPM
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN EP300 BOUND TO THE INHIBITOR XDM3D
Descriptor:Histone acetyltransferase p300, ~{N}-[(1~{S},2~{S})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide, ACETATE ION
Authors:Huegle, M., Wohlwend, D., Gerhardt, S.
Deposit date:2016-08-13
Release date:2017-08-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Angew. Chem. Int. Ed. Engl., 56, 2017
4YK0
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CRYSTAL STRUCTURE OF THE CBP BROMODOMAIN IN COMPLEX WITH CPI098
Descriptor:CREB-binding protein, (4R)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, 1,2-ETHANEDIOL
Authors:Bellon, S.F., Jayaram, H.
Deposit date:2015-03-03
Release date:2016-04-20
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
J.Biol.Chem., 291, 2016
5DBM
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CRYSTAL STRUCTURE OF THE CBP BROMODOMAIN IN COMPLEX WITH CPI703
Descriptor:CREB-binding protein, (4R)-6-(1-tert-butyl-1H-pyrazol-4-yl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one
Authors:Setser, J.W., Poy, F., Bellon, S.F.
Deposit date:2015-08-21
Release date:2016-04-20
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
J.Biol.Chem., 291, 2016
5I83
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP BOUND TO THE BENZODIAZEPINONE G02773986
Descriptor:CREB-binding protein, THIOCYANATE ION, (4R)-4-methyl-7-[(1R)-1-phenylethoxy]-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one
Authors:Jayaram, H., Poy, F., Setser, J.W., Bellon, S.F.
Deposit date:2016-02-18
Release date:2016-04-20
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Acs Med.Chem.Lett., 7, 2016
5I86
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP BOUND TO THE BENZODIAZEPINONE G02778174
Descriptor:CREB-binding protein, 1,2-ETHANEDIOL, THIOCYANATE ION, ...
Authors:Jayaram, H., Poy, F., Setser, J.W., Bellon, S.F.
Deposit date:2016-02-18
Release date:2016-04-20
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Acs Med.Chem.Lett., 7, 2016
5I89
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP BOUND TO THE BENZODIAZEPINONE G02857790
Descriptor:CREB-binding protein, ACETATE ION, CALCIUM ION, ...
Authors:Setser, J.W., Poy, F., Bellon, S.F.
Deposit date:2016-02-18
Release date:2016-04-20
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Acs Med.Chem.Lett., 7, 2016
5I8B
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CBP IN COMPLEX WITH CPD23 ((R)-6-(3-(BENZYLOXY)PHENYL)-4-METHYL-1,3,4,5-TETRAHYDRO-2H-BENZO[B][1,4]DIAZEPIN-2-ONE)
Descriptor:CREB-binding protein, ZINC ION, (4R)-6-[3-(benzyloxy)phenyl]-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, ...
Authors:Murray, J.M.
Deposit date:2016-02-18
Release date:2016-04-20
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (1.5218 Å)
Cite:Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Acs Med.Chem.Lett., 7, 2016
5I8G
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CBP IN COMPLEX WITH CPD637 ((R)-4-METHYL-6-(1-METHYL-3-(1-METHYL-1H-PYRAZOL-4-YL)-1H-INDAZOL-5-YL)-1,3,4,5-TETRAHYDRO-2H-BENZO[B][1,4]DIAZEPIN-2-ONE)
Descriptor:CREB-binding protein, ZINC ION, (4R)-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, ...
Authors:Murray, J.M.
Deposit date:2016-02-18
Release date:2016-04-20
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Acs Med.Chem.Lett., 7, 2016
5KTU
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP BOUND TO PYRAZOLOPIPERIDINE SCAFFOLD
Descriptor:CREB-binding protein, 1-(3-phenylazanyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone, DIMETHYL SULFOXIDE
Authors:Jayaram, H., Poy, F., Setser, J.W., Bellon, S.F.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
5KTW
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CREBBP BROMODOMAIN IN COMPLEX WITH CPD 44 (3-((5-ACETYL-1-(CYCLOPROPYLMETHYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-3-YL)AMINO)-N-ISOPROPYLBENZAMIDE)
Descriptor:CREB-binding protein, 3-[[1-(cyclopropylmethyl)-5-ethanoyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]amino]-~{N}-propan-2-yl-benzamide, 1,2-ETHANEDIOL
Authors:Murray, J.M., Boenig, G.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.087 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
5KTX
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CREBBP BROMODOMAIN IN COMPLEX WITH CPD59 ((S)-1-(3-((2-FLUORO-4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)AMINO)-1-(TETRAHYDROFURAN-3-YL)-6,7-DIHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-5(4H)-YL)ETHANONE)
Descriptor:CREB-binding protein, 1-[3-[[2-fluoranyl-4-(1-methylpyrazol-4-yl)phenyl]amino]-1-[(3~{S})-oxolan-3-yl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-5-yl]ethanone, 1,2-ETHANEDIOL, ...
Authors:Murray, J.M., Noland, C.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
5KU3
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BRD4 BROMODOMAIN IN COMPLEX WITH CPD59 ((S)-1-(3-((2-FLUORO-4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)AMINO)-1-(TETRAHYDROFURAN-3-YL)-6,7-DIHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-5(4H)-YL)ETHANONE)
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
Authors:Murray, J.M., Huang, W.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
5XXH
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CRYSTAL STRUCTURE ANALYSIS OF THE CBP
Descriptor:CREB-binding protein, (3S)-1-[2-(3-ethanoylindol-1-yl)ethanoyl]piperidine-3-carboxylic acid, 1,2-ETHANEDIOL, ...
Authors:Xiang, Q., Zhang, Y., Wang, C., Song, M.
Deposit date:2017-07-04
Release date:2018-06-13
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer.
Eur J Med Chem, 147, 2018
1P4Q
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SOLUTION STRUCTURE OF THE CITED2 TRANSACTIVATION DOMAIN IN COMPLEX WITH THE P300 CH1 DOMAIN
Descriptor:Cbp/p300-interacting transactivator 2, E1A-associated protein p300, ZINC ION
Authors:Freedman, S.J., Sun, Z.-Y.J., Kung, A.L., France, D.S., Wagner, G., Eck, M.J.
Deposit date:2003-04-23
Release date:2003-07-01
Last modified:2017-02-01
Method:SOLUTION NMR
Cite:Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2.
Nat.Struct.Biol., 10, 2003
2K8F
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STRUCTURAL BASIS FOR THE REGULATION OF P53 FUNCTION BY P300
Descriptor:Histone acetyltransferase p300, Cellular tumor antigen p53
Authors:Bai, Y., Feng, H., Jenkins, L.M., Durell, S.R., Wiodawer, A., Appella, E.
Deposit date:2008-09-08
Release date:2009-03-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation.
Structure, 17, 2009
2MH0
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SOLUTION NMR STRUCTURE OF THE P300 TAZ2:ETAD1 COMPLEX
Descriptor:Transcription factor E2-alpha, Histone acetyltransferase p300
Authors:Langelaan, D.N., Smith, S.P., Chitayat, S.
Deposit date:2013-11-12
Release date:2014-11-12
Method:SOLUTION NMR
Cite:Solution NMR structure of the p300 Taz2:ETAD1 complex
To be Published
2MZD
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CHARACTERIZATION OF THE P300 TAZ2-P53 TAD2 COMPLEX AND COMPARISON WITH THE P300 TAZ2-P53 TAD1 COMPLEX
Descriptor:Histone acetyltransferase p300, Cellular tumor antigen p53
Authors:Miller Jenkins, L.M., Feng, H., Durell, S.R., Tagad, H.D., Mazur, S.J., Tropea, J.E., Bai, Y., Appella, E.
Deposit date:2015-02-11
Release date:2015-03-25
Last modified:2015-04-08
Method:SOLUTION NMR
Cite:Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex.
Biochemistry, 54, 2015
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168889
PDB entries from 2020-09-16