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6J3C
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BU of 6j3c by Molmil
Crystal structure of human DHODH in complex with inhibitor 1291
Descriptor: (6R)-1-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-01-04
Release date:2019-08-21
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.
Febs Open Bio, 9, 2019
6JMD
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BU of 6jmd by Molmil
Crystal structure of human DHODH in complex with inhibitor 1223
Descriptor: 3-[3,5-bis(fluoranyl)-4-[3-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-03-08
Release date:2020-03-18
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.781 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6JME
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BU of 6jme by Molmil
Crystal structure of human DHODH in complex with inhibitor 0946
Descriptor: 3-[3,5-bis(fluoranyl)-4-(2-fluorophenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-03-08
Release date:2020-03-18
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
1D3G
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BU of 1d3g by Molmil
HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG
Descriptor: 2-BIPHENYL-4-YL-6-FLUORO-3-METHYL-QUINOLINE-4-CARBOXYLIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ...
Authors:Liu, S, Neidhardt, E.A, Grossman, T.H, Ocain, T, Clardy, J.
Deposit date:1999-09-29
Release date:2000-09-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8, 2000
1D3H
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BU of 1d3h by Molmil
HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH ANTIPROLIFERATIVE AGENT A771726
Descriptor: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ...
Authors:Liu, S, Neidhardt, E.A, Grossman, T.H, Ocain, T, Clardy, J.
Deposit date:1999-09-29
Release date:2000-08-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8, 2000
6LP7
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BU of 6lp7 by Molmil
Crystal structure of human DHODH in complex with inhibitor 0944
Descriptor: 3-[3,5-bis(fluoranyl)-4-(3-methoxyphenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Chen, Q, Yu, Y.
Deposit date:2020-01-09
Release date:2020-09-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6LZL
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BU of 6lzl by Molmil
Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine
Descriptor: (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Liu, Z.H, Wu, D, Lu, W.Q, Huang, J.
Deposit date:2020-02-19
Release date:2020-04-15
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine
To Be Published
1F76
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BU of 1f76 by Molmil
ESCHERICHIA COLI DIHYDROOROTATE DEHYDROGENASE
Descriptor: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, FORMIC ACID, ...
Authors:Norager, S, Jensen, K.F, Bjornberg, O, Larsen, S.
Deposit date:2000-06-26
Release date:2002-10-16
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinction between different classes of dihydroorotate dehydrogenases
Structure, 10, 2002
6LP6
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BU of 6lp6 by Molmil
Crystal structure of human DHODH in complex with inhibitor 1214
Descriptor: 3-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Chen, Q, Yu, Y.
Deposit date:2020-01-09
Release date:2020-09-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.795 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6LP8
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BU of 6lp8 by Molmil
Crystal structure of human DHODH in complex with inhibitor 1243
Descriptor: 3-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Chen, Q, Yu, Y.
Deposit date:2020-01-09
Release date:2020-09-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6M2B
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BU of 6m2b by Molmil
Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416
Descriptor: 2-[(E)-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-methyl-hydrazinylidene]methyl]benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Zhu, L, Li, H.
Deposit date:2020-02-27
Release date:2021-03-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Protein Cell, 11, 2020
1DOR
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BU of 1dor by Molmil
DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS
Descriptor: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE
Authors:Rowland, P, Larsen, S.
Deposit date:1997-01-14
Release date:1997-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis.
Structure, 5, 1997
5ZFB
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BU of 5zfb by Molmil
Structure of human dihydroorotate dehydrogenase in complex with ascofuranone (open-form)
Descriptor: 3-chloro-4,6-dihydroxy-5-[(2Z,6Z,8E)-11-hydroxy-3,7,11-trimethyl-10-oxododeca-2,6,8-trien-1-yl]-2-methylbenzaldehyde, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
5XFW
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BU of 5xfw by Molmil
Crystal structures of FMN-free form of dihydroorotate dehydrogenase from Trypanosoma brucei
Descriptor: Dihydroorotate dehydrogenase (fumarate), MALONATE ION
Authors:Kubota, T, Tani, O, Yamaguchi, T, Namatame, I, Sakashita, H, Furukawa, K, Yamasaki, K.
Deposit date:2017-04-11
Release date:2018-04-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase fromTrypanosoma brucei.
FEBS Open Bio, 8, 2018
6AJ5
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BU of 6aj5 by Molmil
Crystal structure of ligand-free type DHODH from Eimeria tenella
Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Shiba, T, Inaoka, D.K, Sato, D, Hartuti, E.D, Amalia, E, Nagahama, M, Yoshioka, Y, Matsubayashi, M, Balogun, E.O, Tsuji, N, Kita, K, Harada, S.
Deposit date:2018-08-27
Release date:2019-08-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.
Genes (Basel), 11, 2020
5ZF9
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BU of 5zf9 by Molmil
Structure of human dihydroorotate dehydrogenase in complex with 280-12
Descriptor: 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzaldehyde, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
5ZF4
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BU of 5zf4 by Molmil
Structure of human dihydroorotate dehydrogenase in complex with 275-10-COOMe
Descriptor: ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
5ZFA
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BU of 5zfa by Molmil
Structure of human dihydroorotate dehydrogenase in complex with 287-12-OCOiPr
Descriptor: (2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,6-dimethylocta-2,6-dien-1-yl 2-methylpropanoate, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
5ZF8
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BU of 5zf8 by Molmil
Structure of human dihydroorotate dehydrogenase in complex with 277-11-OAc
Descriptor: (2S,3E,7E)-9-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,7-dimethylnona-3,7-dien-2-yl acetate, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
6AJE
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BU of 6aje by Molmil
Crystal structure of DHODH in complex with ferulenol from Eimeria tenella
Descriptor: 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Shiba, T, Inaoka, D.K, Sato, D, Hartuti, E.D, Amalia, E, Nagahama, M, Yoshioka, Y, Matsubayashi, M, Balogun, E.O, Tsuji, N, Kita, K, Harada, S.
Deposit date:2018-08-27
Release date:2019-08-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.
Genes (Basel), 11, 2020
5ZF7
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BU of 5zf7 by Molmil
Structure of human dihydroorotate dehydrogenase in complex with 277-9-OH
Descriptor: 3-chloro-4,6-dihydroxy-5-[(2E,6E,8S)-8-hydroxy-3,7-dimethylnona-2,6-dien-1-yl]-2-methylbenzaldehyde, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
6B8S
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BU of 6b8s by Molmil
Crystal Structure of Dihydroorotate Dehydrogenase from Helicobacter pylori with bound FMN
Descriptor: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, TRIETHYLENE GLYCOL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-10-09
Release date:2017-11-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of Dihydroorotate Dehydrogenase from Helicobacter pylori with bound FMN
to be published
2DJL
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BU of 2djl by Molmil
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with succinate
Descriptor: COBALT HEXAMMINE(III), FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K.
Deposit date:2006-04-04
Release date:2007-06-26
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with succinate
To be Published
2BXV
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BU of 2bxv by Molmil
Dual binding mode of a novel series of DHODH inhibitors
Descriptor: 2-({[3-FLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ...
Authors:Baumgartner, R, Walloschek, M, Karlik, M, Gotschlich, A, Tasler, S, Mies, J, Leban, J.
Deposit date:2005-07-27
Release date:2006-08-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Dual binding mode of a novel series of DHODH inhibitors.
J. Med. Chem., 49, 2006
2DJX
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BU of 2djx by Molmil
Crystal structure of native Trypanosoma cruzi dihydroorotate dehydrogenase
Descriptor: COBALT HEXAMMINE(III), Dihydroorotate Dehydrogenase, FLAVIN MONONUCLEOTIDE
Authors:Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K.
Deposit date:2006-04-05
Release date:2007-06-26
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structure of native Trypanosoma cruzi dihydroorotate dehydrogenase
To be Published

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