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6K2M
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Crystal structure of the complex of Proliferating Cell Nuclear Antigen from Leishmania donovani with arginine at 3.19 A resolution.
Descriptor: ARGININE, Proliferating cell nuclear antigen
Authors:Viswanathan, V, Iqbal, N, Sharma, S, Singh, T.P.
Deposit date:2019-05-15
Release date:2019-05-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Crystal structure of the complex of Proliferating Cell Nuclear Antigen from Leishmania donovani with arginine at 3.19 A resolution.
To Be Published
6K3A
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BU of 6k3a by Molmil
Crystal structure of human PCNA in complex with DNMT1 PIP box motif.
Descriptor: Peptide from DNA (cytosine-5)-methyltransferase 1, Proliferating cell nuclear antigen
Authors:Jimenji, T, Kori, S, Arita, K.
Deposit date:2019-05-17
Release date:2019-06-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of PCNA in complex with DNMT1 PIP box reveals the basis for the molecular mechanism of the interaction.
Biochem.Biophys.Res.Commun., 516, 2019
7QNZ
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BU of 7qnz by Molmil
human Lig1-DNA-PCNA complex reconstituted in absence of ATP
Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Oligo13P, ...
Authors:Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A.
Deposit date:2021-12-23
Release date:2023-01-11
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.58 Å)
Cite:Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Nat Commun, 13, 2022
7QO1
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BU of 7qo1 by Molmil
complex of DNA ligase I and FEN1 on PCNA and DNA
Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Flap endonuclease 1, ...
Authors:Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A.
Deposit date:2021-12-23
Release date:2023-01-11
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Nat Commun, 13, 2022
7RPW
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Archaeal DNA ligase and heterotrimeric PCNA in complex with adenylated DNA
Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase, DNA polymerase sliding clamp 1, ...
Authors:Sverzhinsky, A, Pascal, J.M.
Deposit date:2021-08-04
Release date:2021-11-17
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.38 Å)
Cite:Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
Structure, 30, 2022
7RPO
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Archaeal DNA ligase and heterotrimeric PCNA in complex with non-ligatable DNA
Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase, DNA polymerase sliding clamp 1, ...
Authors:Sverzhinsky, A, Pascal, J.M.
Deposit date:2021-08-03
Release date:2021-11-17
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (4.16 Å)
Cite:Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
Structure, 30, 2022
7RPX
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BU of 7rpx by Molmil
Archaeal DNA ligase and heterotrimeric PCNA in complex with end-joined DNA
Descriptor: DNA ligase, DNA polymerase sliding clamp 1, DNA polymerase sliding clamp 2, ...
Authors:Sverzhinsky, A, Pascal, J.M.
Deposit date:2021-08-04
Release date:2021-11-17
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
Structure, 30, 2022
6T7X
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BU of 6t7x by Molmil
Crystal structure of PCNA from P. abyssi
Descriptor: DNA polymerase sliding clamp
Authors:Madru, C, Raia, P, Hugonneau Beaufet, I, Delarue, M, Carroni, M, Sauguet, L.
Deposit date:2019-10-23
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.
Nat Commun, 11, 2020
3VKX
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BU of 3vkx by Molmil
Structure of PCNA
Descriptor: 3,5,3'TRIIODOTHYRONINE, CHLORIDE ION, Proliferating cell nuclear antigen, ...
Authors:Hashimoto, H, Hishiki, A, Shimizu, T, Sato, M, Punchihewa, C, Connelly, M, Actis, M, Waddell, B, Pagala, V, Fujii, N.
Deposit date:2011-11-26
Release date:2012-03-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
J.Biol.Chem., 287, 2012
8P9O
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BU of 8p9o by Molmil
PCNA from Chaetomium thermophilum in complex with PolD3 peptide
Descriptor: Proliferating cell nuclear antigen, Synthetic peptide corresponding to amino acids 437 to 451 of PolD3 from Chaetomium thermophilum
Authors:Alphey, M.S, Wolford, C.B, MacNeill, S.A.
Deposit date:2023-06-06
Release date:2023-12-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Canonical binding of Chaetomium thermophilum DNA polymerase delta / zeta subunit PolD3 and flap endonuclease Fen1 to PCNA.
Front Mol Biosci, 10, 2023
8Q7I
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BU of 8q7i by Molmil
PCNA from Chaetomium thermophilum in complex with Fen1 peptide
Descriptor: Flap endonuclease 1, Proliferating cell nuclear antigen, SODIUM ION
Authors:Alphey, M.S, Wolford, C.B, MacNeill, S.A.
Deposit date:2023-08-16
Release date:2023-12-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Canonical binding of Chaetomium thermophilum DNA polymerase delta / zeta subunit PolD3 and flap endonuclease Fen1 to PCNA.
Front Mol Biosci, 10, 2023
6KNC
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BU of 6knc by Molmil
PolD-PCNA-DNA (form B)
Descriptor: DNA polymerase D DP2 (DNA polymerase II large) subunit, DNA polymerase II small subunit, DNA polymerase sliding clamp 1, ...
Authors:Mayanagi, K, Oki, K, Miyazaki, N, Ishino, S, Yamagami, T, Iwasaki, K, Kohda, D, Morikawa, K, Shirai, T, Ishino, Y.
Deposit date:2019-08-05
Release date:2020-08-05
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (9.3 Å)
Cite:Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy.
Bmc Biol., 18, 2020
6KNB
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BU of 6knb by Molmil
PolD-PCNA-DNA (form A)
Descriptor: DNA polymerase D DP2 (DNA polymerase II large) subunit, DNA polymerase II small subunit, DNA polymerase sliding clamp 1, ...
Authors:Mayanagi, K, Oki, K, Miyazaki, N, Ishino, S, Yamagami, T, Iwasaki, K, Kohda, D, Morikawa, K, Shirai, T, Ishino, Y.
Deposit date:2019-08-05
Release date:2020-08-05
Last modified:2021-02-17
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy.
Bmc Biol., 18, 2020
2HII
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BU of 2hii by Molmil
heterotrimeric PCNA sliding clamp
Descriptor: PCNA1 (SSO0397), PCNA2 (SSO1047), PCNA3 (SSO0405)
Authors:Pascal, J.M, Tsodikov, O.V, Ellenberger, T.
Deposit date:2006-06-29
Release date:2006-11-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA.
Mol.Cell, 24, 2006
2HIK
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BU of 2hik by Molmil
heterotrimeric PCNA sliding clamp
Descriptor: PCNA1 (SSO0397), PCNA2 (SSO1047), PCNA3 (SSO0405)
Authors:Pascal, J.M, Tsodikov, O.V, Ellenberger, T.
Deposit date:2006-06-29
Release date:2006-11-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA.
Mol.Cell, 24, 2006
3GPM
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BU of 3gpm by Molmil
Structure of the trimeric form of the E113G PCNA mutant protein
Descriptor: Proliferating cell nuclear antigen
Authors:Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T.
Deposit date:2009-03-23
Release date:2009-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions.
Acta Crystallogr.,Sect.D, 65, 2009
5E0T
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BU of 5e0t by Molmil
Human PCNA mutant - S228I
Descriptor: Proliferating cell nuclear antigen
Authors:Duffy, C.M, Hilbert, B.J, Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6653 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
3HI8
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BU of 3hi8 by Molmil
Crystal structure of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii
Descriptor: Proliferating cell nuclear antigen PcnA
Authors:Morgunova, E, Gray, F.C, MacNeill, S.A, Ladenstein, R.
Deposit date:2009-05-19
Release date:2009-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.202 Å)
Cite:Structural insights into the adaptation of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii to a high-salt environment.
Acta Crystallogr.,Sect.D, 65, 2009
2IO4
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BU of 2io4 by Molmil
Crystal structure of PCNA12 dimer from Sulfolobus solfataricus.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, DNA polymerase sliding clamp B, ...
Authors:Hlinkova, V, Ling, H.
Deposit date:2006-10-09
Release date:2008-04-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of monomeric, dimeric and trimeric PCNA: PCNA-ring assembly and opening.
Acta Crystallogr.,Sect.D, 64, 2008
3IFV
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BU of 3ifv by Molmil
Crystal structure of the Haloferax volcanii proliferating cell nuclear antigen
Descriptor: PCNA, SODIUM ION
Authors:Winter, J.A, Christofi, P, Morroll, S, Bunting, K.A.
Deposit date:2009-07-26
Release date:2009-09-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of Haloferax volcanii proliferating cell nuclear antigen reveals unique surface charge characteristics due to halophilic adaptation
Bmc Struct.Biol., 9, 2009
5DA7
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BU of 5da7 by Molmil
monomeric PCNA bound to a small protein inhibitor
Descriptor: DNA polymerase sliding clamp 1, Proliferating cell nuclear antigen, SULFATE ION, ...
Authors:Ladner, J.E, Altieri, A.S, Kelman, Z.
Deposit date:2015-08-19
Release date:2016-05-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clamp.
Nucleic Acids Res., 44, 2016
5E0U
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BU of 5e0u by Molmil
Human PCNA variant (S228I) complexed with p21 at 1.9 Angstroms
Descriptor: Cyclin-dependent kinase inhibitor 1, Proliferating cell nuclear antigen
Authors:Duffy, C.M, Hilbert, B.J, Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
5E0V
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BU of 5e0v by Molmil
Human PCNA variant (S228I) complexed with FEN1 at 2.1 Angstroms
Descriptor: Flap endonuclease 1, Proliferating cell nuclear antigen
Authors:Duffy, C.M, Hilbert, B.J, Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.074 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
2IJX
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BU of 2ijx by Molmil
Crystal structure of PCNA3 monomer from Sulfolobus solfataricus.
Descriptor: 1,2-ETHANEDIOL, DNA polymerase sliding clamp A
Authors:Hlinkova, V, Ling, H.
Deposit date:2006-10-01
Release date:2007-10-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of monomeric, dimeric and trimeric PCNA: PCNA-ring assembly and opening.
Acta Crystallogr.,Sect.D, 64, 2008
2IZO
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BU of 2izo by Molmil
Structure of an Archaeal PCNA1-PCNA2-FEN1 Complex
Descriptor: DNA POLYMERASE SLIDING CLAMP B, DNA POLYMERASE SLIDING CLAMP C, FLAP STRUCTURE-SPECIFIC ENDONUCLEASE, ...
Authors:Dore, A.S, Kilkenny, M.L, Roe, S.M, Pearl, L.H.
Deposit date:2006-07-25
Release date:2006-09-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of an Archaeal PCNA1-PCNA2-Fen1 Complex: Elucidating PCNA Subunit and Client Enzyme Specificity.
Nucleic Acids Res., 34, 2006

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