3IFV
Crystal structure of the Haloferax volcanii proliferating cell nuclear antigen
Summary for 3IFV
| Entry DOI | 10.2210/pdb3ifv/pdb |
| Descriptor | PCNA, SODIUM ION (3 entities in total) |
| Functional Keywords | processivity factor, sliding clamp, halophilic, replication |
| Biological source | Haloferax volcanii (Haloferax volcanii) |
| Total number of polymer chains | 3 |
| Total formula weight | 80294.89 |
| Authors | Winter, J.A.,Christofi, P.,Morroll, S.,Bunting, K.A. (deposition date: 2009-07-26, release date: 2009-09-01, Last modification date: 2023-11-01) |
| Primary citation | Winter, J.A.,Christofi, P.,Morroll, S.,Bunting, K.A. The crystal structure of Haloferax volcanii proliferating cell nuclear antigen reveals unique surface charge characteristics due to halophilic adaptation Bmc Struct.Biol., 9:55-55, 2009 Cited by PubMed Abstract: The high intracellular salt concentration required to maintain a halophilic lifestyle poses challenges to haloarchaeal proteins that must stay soluble, stable and functional in this extreme environment. Proliferating cell nuclear antigen (PCNA) is a fundamental protein involved in maintaining genome integrity, with roles in both DNA replication and repair. To investigate the halophilic adaptation of such a key protein we have crystallised and solved the structure of Haloferax volcanii PCNA (HvPCNA) to a resolution of 2.0 A. PubMed: 19698123DOI: 10.1186/1472-6807-9-55 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report
