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5DMY
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BU of 5dmy by Molmil
Beta-galactosidase - construct 33-930
Descriptor: 1,2-ETHANEDIOL, Beta-galactosidase, MAGNESIUM ION, ...
Authors:Watson, K.A, Lazidou, A.
Deposit date:2015-09-09
Release date:2016-10-05
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Rational protein engineering toward the development of a beta-galactosidase with improved functional properties
To Be Published
4DUX
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BU of 4dux by Molmil
E. coli (lacZ) beta-galactosidase (N460S) in complex with L-ribose
Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ...
Authors:Wheatley, R.W, Lo, S, Janzcewicz, L.J, Dugdale, M.L, Huber, R.E.
Deposit date:2012-02-22
Release date:2013-03-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural explanation for allolactose (lac operon inducer) synthesis by lacZ beta-galactosidase and the evolutionary relationship between allolactose synthesis and the lac repressor.
J.Biol.Chem., 288, 2013
5CZK
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BU of 5czk by Molmil
Structure of E. coli beta-glucuronidase bound with a novel, potent inhibitor 1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea
Descriptor: 1-[(6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea, Beta-glucuronidase
Authors:Roberts, A.R, Wallace, B.R, Redinbo, M.R.
Deposit date:2015-07-31
Release date:2015-10-14
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure and Inhibition of Microbiome beta-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.
Chem.Biol., 22, 2015
5EUV
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BU of 5euv by Molmil
Crystal structure of a cold-adapted dimeric beta-D-galactosidase from Paracoccus sp. 32d strain
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Beta-D-galactosidase, ...
Authors:Rutkiewicz-Krotewicz, M, Bujacz, A, Pietrzyk, A.J, Sekula, B, Bujacz, G.
Deposit date:2015-11-19
Release date:2016-09-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural studies of a cold-adapted dimeric beta-D-galactosidase from Paracoccus sp. 32d.
Acta Crystallogr D Struct Biol, 72, 2016
3OB8
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BU of 3ob8 by Molmil
Structure of the beta-galactosidase from Kluyveromyces lactis in complex with galactose
Descriptor: Beta-galactosidase, MAGNESIUM ION, MANGANESE (II) ION, ...
Authors:Fernandez-Leiro, R, Pereira-Rodriguez, A, Becerra, M, Gonzalez-Siso, I, Cerdan, M.E, Sanz-Aparicio, J.
Deposit date:2010-08-06
Release date:2011-08-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of specificity in tetrameric Kluyveromyces lactis beta-galactosidase.
J.Struct.Biol., 177, 2012
3MUZ
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BU of 3muz by Molmil
E.Coli (lacZ) beta-galactosidase (R599A) in complex with IPTG
Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ...
Authors:Dugdale, M.L, Vance, M.L, Driedger, M.R, Nibber, A, Tran, A, Huber, R.E.
Deposit date:2010-05-03
Release date:2011-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Importance of Arg-599 of b-galactosidase (Escherichia coli) as an anchor for the open conformations of Phe-601 and the active-site loop
Biochem.Cell Biol., 88, 2010
8GEN
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BU of 8gen by Molmil
E. eligens beta-glucuronidase bound to UNC10201652-glucuronide
Descriptor: 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, Beta-glucuronidase
Authors:Simpson, J.B, Redinbo, M.R.
Deposit date:2023-03-07
Release date:2024-02-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Cell Host Microbe, 32, 2024
6SD0
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BU of 6sd0 by Molmil
Structure of beta-galactosidase from Thermotoga maritima.
Descriptor: Beta-galactosidase, MAGNESIUM ION
Authors:Jimenez-Ortega, E, Ramirez-Escudero, M, Sanz-Aparicio, J.
Deposit date:2019-07-26
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:The cryo-EM Structure ofThermotoga maritimabeta-Galactosidase: Quaternary Structure Guides Protein Engineering.
Acs Chem.Biol., 15, 2020
8GEQ
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BU of 8geq by Molmil
E. eligens beta-glucuronidase bound to ceritinib-glucuronide
Descriptor: 4-amino-5-chloro-2-{4-(1-beta-D-glucopyranuronosylpiperidin-4-yl)-5-methyl-2-[(propan-2-yl)oxy]anilino}pyrimidine, Beta-glucuronidase
Authors:Simpson, J.B, Kowalewski, M.K, Redinbo, M.R.
Deposit date:2023-03-07
Release date:2024-02-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Cell Host Microbe, 32, 2024
8GES
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BU of 8ges by Molmil
R. hominis 2 beta-glucuronidase bound to UNC10201652-glucuronide
Descriptor: 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Simpson, J.B, Redinbo, M.R.
Deposit date:2023-03-07
Release date:2024-02-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Cell Host Microbe, 32, 2024
8GER
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BU of 8ger by Molmil
E. eligens beta-glucuronidase bound to norquetiapine-glucuronide
Descriptor: 11-(4-beta-D-glucopyranuronosylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine, Beta-glucuronidase
Authors:Simpson, J.B, Lietzan, A.D, Redinbo, M.R.
Deposit date:2023-03-07
Release date:2024-03-20
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Cell Host Microbe, 32, 2024
8GEO
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BU of 8geo by Molmil
E. eligens beta-glucuronidase bound to 3-OH-desloratidine-glucuronide
Descriptor: 8-chloro-11-(1-beta-D-glucopyranuronosylpiperidin-4-ylidene)-3-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Beta-glucuronidase, GLYCEROL
Authors:Simpson, J.B, Redinbo, M.R.
Deposit date:2023-03-07
Release date:2024-03-20
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Cell Host Microbe, 32, 2024
8GET
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BU of 8get by Molmil
R. hominis 2 beta-glucuronidase bound to norquetiapine-glucuronide
Descriptor: 11-(4-beta-D-glucopyranuronosylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Simpson, J.B, Redinbo, M.R.
Deposit date:2023-03-07
Release date:2024-03-20
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Cell Host Microbe, 32, 2024
5Z19
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BU of 5z19 by Molmil
The crystal structure of Ruminococcus gnavus beta-glucuronidase in complex with uronic isofagomine
Descriptor: (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid, Beta-glucuronidase
Authors:Dashnyam, P, Lin, H.Y, Lin, C.H.
Deposit date:2017-12-25
Release date:2018-12-12
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Dissection of the substrate preference and structure of gut microbial beta-glucuronidases identifies the major bacteria causing xenobiotic toxicity
To Be Published
6U7J
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BU of 6u7j by Molmil
Uncultured Clostridium sp. Beta-glucuronidase
Descriptor: Beta-glucuronidase, CALCIUM ION
Authors:Ervin, S.M, Redinbo, M.R.
Deposit date:2019-09-03
Release date:2019-10-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Gut microbial beta-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens.
J.Biol.Chem., 294, 2019
5Z1A
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BU of 5z1a by Molmil
The crystal structure of Bacteroides fragilis beta-glucuronidase in complex with uronic isofagomine
Descriptor: (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid, Putative beta-galactosidase
Authors:Dashnyam, P, Lin, H.Y, Lin, C.H.
Deposit date:2017-12-25
Release date:2018-12-12
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.859 Å)
Cite:Dissection of the substrate preference and structure of gut microbial-glucuronidases identifies the major bacteria causing xenobiotic toxicity
To Be Published
6TSH
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BU of 6tsh by Molmil
Beta-galactosidase in complex with deoxygalacto-nojirimycin
Descriptor: (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, Beta-galactosidase, MAGNESIUM ION
Authors:Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A.
Deposit date:2019-12-20
Release date:2020-01-08
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Fragment-based drug discovery using cryo-EM.
Drug Discov Today, 25, 2020
5Z18
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BU of 5z18 by Molmil
The crystal structure of Ruminococcus gnavus beta-glucuronidase
Descriptor: Beta-glucuronidase
Authors:Dashnyam, P, Lin, H.Y, Lin, C.H.
Deposit date:2017-12-25
Release date:2018-12-12
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Dissection of the substrate preference and structure of gut microbial beta-glucuronidases identifies the major bacteria causing xenobiotic toxicity
To Be Published
6TTE
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BU of 6tte by Molmil
Beta-galactosidase in complex with PETG
Descriptor: 2-phenylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, MAGNESIUM ION
Authors:Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A.
Deposit date:2019-12-27
Release date:2020-01-15
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Fragment-based drug discovery using cryo-EM.
Drug Discov Today, 25, 2020
5Z1B
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BU of 5z1b by Molmil
Structure of Bifidobacterium dentium beta-glucuronidase complexed with coumarin-3-O-glucuronide
Descriptor: 3-HYDROXY-2H-CHROMEN-2-ONE, Glycosyl hydrolase family 2, TIM barrel domain protein, ...
Authors:Dashnyam, P, Lin, H.Y, Lin, C.H.
Deposit date:2017-12-25
Release date:2018-12-12
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Dissection of the substrate preference and structure of gut microbial-glucuronidases identifies the major bacteria causing xenobiotic toxicity
To Be Published
6TSK
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BU of 6tsk by Molmil
Beta-galactosidase in complex with L-ribose
Descriptor: Beta-galactosidase, MAGNESIUM ION, beta-L-ribopyranose
Authors:Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A.
Deposit date:2019-12-20
Release date:2020-01-08
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Fragment-based drug discovery using cryo-EM.
Drug Discov Today, 25, 2020
6U7I
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BU of 6u7i by Molmil
Faecalibacterium prausnitzii Beta-glucuronidase
Descriptor: Beta-glucuronidase
Authors:Ervin, S.M, Redinbo, M.R.
Deposit date:2019-09-03
Release date:2019-10-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Gut microbial beta-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens.
J.Biol.Chem., 294, 2019
6B6L
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BU of 6b6l by Molmil
The crystal structure of glycosyl hydrolase family 2 (GH2) member from Bacteroides cellulosilyticus DSM 14838
Descriptor: 1,2-ETHANEDIOL, FORMIC ACID, Glycosyl hydrolase family 2, ...
Authors:Tan, K, Joachimiak, G, Nocek, B, Enddres, M, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2017-10-02
Release date:2017-10-11
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of glycosyl hydrolase family 2 (GH2) member from Bacteroides cellulosilyticus DSM 14838
To Be Published
6BJQ
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BU of 6bjq by Molmil
Eubacterium eligens beta-glucuronidase bound to glucuronic acid
Descriptor: Glycoside Hydrolase Family 2 candidate b-glucuronidase, beta-D-glucopyranuronic acid
Authors:Pellock, S.J, Walton, W.G, Redinbo, M.R.
Deposit date:2017-11-06
Release date:2018-07-25
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Gut Microbial beta-Glucuronidase Inhibition via Catalytic Cycle Interception.
ACS Cent Sci, 4, 2018
3DYM
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BU of 3dym by Molmil
E. coli (lacZ) beta-galactosidase (H418E)
Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ...
Authors:Juers, D.H, Huber, R.E, Matthews, B.W.
Deposit date:2008-07-28
Release date:2008-10-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Direct and indirect roles of His-418 in metal binding and in the activity of beta-galactosidase (E. coli).
Protein Sci., 18, 2009

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PDB entries from 2024-09-18

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