PDB Search results for query - Protein Data Bank Japan

PDB: 339 results Info pages Status search Chemie search BIRD

STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME
Descriptor:	INTERLEUKIN-1 BETA CONVERTING ENZYME, TETRAPEPTIDE ALDEHYDE
Authors:	Wilson, K.P, Griffith, J.P, Kim, E.E, Navia, M.A.
Deposit date:	1994-09-29
Release date:	1995-07-28
Last modified:	2012-12-12
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structure and mechanism of interleukin-1 beta converting enzyme. Nature, 370, 1994

3BIJ

Crystal structure of protein GSU0716 from Geobacter sulfurreducens. Northeast Structural Genomics target GsR13
Descriptor:	Uncharacterized protein GSU0716
Authors:	Forouhar, F, Neely, H, Su, M, Seetharaman, J, Benach, J, Conover, K, Fang, Y, Xiao, R, Owen, L.A, Maglaqui, M, Cunningham, K, Baran, M.C, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:	2007-11-30
Release date:	2007-12-11
Last modified:	2017-10-25
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal structure of protein GSU0716 from Geobacter sulfurreducens. To be Published

1JXQ

Structure of cleaved, CARD domain deleted Caspase-9
Descriptor:	Caspase-9, benzoxycarbonyl-Val-Ala-Asp-fluoromethyl ketone Inhibitor
Authors:	Renatus, M, Stennicke, H.R, Scott, F.L, Liddington, R.C, Salvesen, G.S.
Deposit date:	2001-09-08
Release date:	2001-12-12
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Dimer formation drives the activation of the cell death protease caspase 9. Proc.Natl.Acad.Sci.USA, 98, 2001

3D6M

Crystal structure of human caspase-1 with a naturally-occurring Lys319->Arg substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:	2008-05-19
Release date:	2010-03-02
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008

3D6F

Crystal structure of human caspase-1 with a naturally-occurring Arg240->Gln substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:	2008-05-19
Release date:	2010-03-02
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published

3D6H

Crystal structure of human caspase-1 with a naturally-occurring Asn263->Ser substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, Caspase-1 precursor, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:	2008-05-19
Release date:	2010-03-02
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008

1K86

Crystal structure of caspase-7
Descriptor:	caspase-7
Authors:	Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y.
Deposit date:	2001-10-23
Release date:	2001-11-21
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding Cell(Cambridge,Mass.), 107, 2001

3DEJ

Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors
Descriptor:	(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3
Authors:	Wu, J, Du, J, Li, J, Ding, J.
Deposit date:	2008-06-10
Release date:	2008-09-02
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008

1K88

Crystal structure of procaspase-7
Descriptor:	procaspase-7
Authors:	Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y.
Deposit date:	2001-10-23
Release date:	2001-11-21
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding Cell(Cambridge,Mass.), 107, 2001

3DEH

Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors
Descriptor:	Caspase-3, isoquinoline-1,3,4(2H)-trione
Authors:	Wu, J, Du, J, Li, J, Ding, J.
Deposit date:	2008-06-10
Release date:	2008-09-02
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008

3DEI

Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors
Descriptor:	(1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3
Authors:	Wu, J, Du, J, Li, J, Ding, J.
Deposit date:	2008-06-10
Release date:	2008-09-02
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008

3DEK

Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors
Descriptor:	Caspase-3, N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
Authors:	Wu, J, Du, J, Li, J, Ding, J.
Deposit date:	2008-06-10
Release date:	2008-09-02
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008

3EDR

The crystal structure of caspase-7 in complex with Acetyl-LDESD-CHO
Descriptor:	Caspase-7, Inhibitor Ac-ldesd-cho peptide
Authors:	Agniswamy, J.
Deposit date:	2008-09-03
Release date:	2008-10-28
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Structural basis for executioner caspase recognition of P5 position in substrates. Apoptosis, 13, 2008

3E4C

Procaspase-1 zymogen domain crystal structure
Descriptor:	Caspase-1, MAGNESIUM ION
Authors:	Elliott, J.M, Rouge, L, Wiesmann, C, Scheer, J.M.
Deposit date:	2008-08-11
Release date:	2008-12-30
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation J.Biol.Chem., 284, 2009

3EDQ

Crystal structure of Caspase-3 with inhibitor AC-LDESD-CHO
Descriptor:	AC-LDESD-CHO peptide, Caspase-3
Authors:	Fu, G.
Deposit date:	2008-09-03
Release date:	2008-10-28
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.61 Å)
Cite:	Structural basis for executioner caspase recognition of P5 position in substrates. Apoptosis, 13, 2008

1M72

Crystal Structure of Caspase-1 from Spodoptera frugiperda
Descriptor:	1,2-ETHANEDIOL, Ace-Asp-Glu-Val-Asp-chloromethylketone, Caspase-1
Authors:	Forsyth, C.M, Lemongello, D, Friesen, P.D, Fisher, A.J.
Deposit date:	2002-07-18
Release date:	2004-01-20
Last modified:	2013-02-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal structure of an invertebrate caspase. J.Biol.Chem., 279, 2004

8EG6

huCaspase-6 in complex with inhibitor 2a
Descriptor:	(3R)-1-(ethanesulfonyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxamide, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:	Zhao, Y, Fan, P, Liu, J, Wang, Y, Van Horn, K, Wang, D, Medina-Cleghorn, D, Lee, P, Bryant, C, Altobelli, C, Jaishankar, P, Ng, R.A, Ambrose, A.J, Tang, Y, Arkin, M.R, Renslo, A.R.
Deposit date:	2022-09-11
Release date:	2023-05-10
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.82 Å)
Cite:	Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. J.Am.Chem.Soc., 145, 2023

8EG5

huCaspase-6 in complex with inhibitor 3a
Descriptor:	(3R,5S)-1-(ethanesulfonyl)-5-phenyl-N-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxamide (bound form), 1,2-ETHANEDIOL, Caspase-6 subunit p11, ...
Authors:	Zhao, Y, Fan, P, Liu, J, Wang, Y, Van Horn, K, Wang, D, Medina-Cleghorn, D, Lee, P, Bryant, C, Altobelli, C, Jaishankar, P, Ng, R.A, Ambrose, A.J, Tang, Y, Arkin, M.R, Renslo, A.R.
Deposit date:	2022-09-11
Release date:	2023-05-10
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.14 Å)
Cite:	Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. J.Am.Chem.Soc., 145, 2023

8F99

Compound 10 bound to procaspase-6
Descriptor:	5-fluoro-2-({[(3M)-3-(1,3-oxazol-4-yl)pyridin-2-yl]amino}methyl)phenol, Procaspase-6
Authors:	Fan, P, Zhao, Y, Renslo, A.R, Arkin, M.R.
Deposit date:	2022-11-23
Release date:	2023-12-13
Method:	X-RAY DIFFRACTION (2.86 Å)
Cite:	A Comprehensive Empirical-Computational Study of Diverse Heteroarene Stacking Interactions Under Physiological Conditions To Be Published

8F97

Compound 5 bound to procaspase-6
Descriptor:	1,2-ETHANEDIOL, 2-({[(2M)-[2,3'-bipyridin]-2'-yl]amino}methyl)-5-fluorophenol, CHLORIDE ION, ...
Authors:	Fan, P, Zhao, Y, Renslo, A.R, Arkin, M.R.
Deposit date:	2022-11-23
Release date:	2023-12-13
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	A Comprehensive Empirical-Computational Study of Diverse Heteroarene Stacking Interactions Under Physiological Conditions To Be Published

8F98

Compound 8 bound to procaspase-6
Descriptor:	5-fluoro-2-({[(3M)-3-(1H-imidazol-4-yl)pyridin-2-yl]amino}methyl)phenol, Procaspase-6
Authors:	Fan, P, Zhao, Y, Renslo, A.R, Arkin, M.R.
Deposit date:	2022-11-23
Release date:	2023-12-13
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	A Comprehensive Empirical-Computational Study of Diverse Heteroarene Stacking Interactions Under Physiological Conditions To Be Published

8F9B

Compound 19 bound to procaspase-6
Descriptor:	5-fluoro-2-({[(3M)-3-(1,2-thiazol-3-yl)pyridin-2-yl]amino}methyl)phenol, Procaspase-6
Authors:	Fan, P, Zhao, Y, Renslo, A.R, Arkin, M.R.
Deposit date:	2022-11-23
Release date:	2023-12-13
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	A Comprehensive Empirical-Computational Study of Diverse Heteroarene Stacking Interactions Under Physiological Conditions To Be Published

8F9A

Compound 11 bound to procaspase-6
Descriptor:	5-fluoro-2-({[(3M)-3-(1,2-oxazol-3-yl)pyridin-2-yl]amino}methyl)phenol, Procaspase-6
Authors:	Fan, P, Zhao, Y, Renslo, A.R, Arkin, M.R.
Deposit date:	2022-11-23
Release date:	2023-12-13
Method:	X-RAY DIFFRACTION (2.55 Å)
Cite:	A Comprehensive Empirical-Computational Study of Diverse Heteroarene Stacking Interactions Under Physiological Conditions To Be Published

8F78

Compound 1 bound to procaspase-6
Descriptor:	5-fluoro-2-({[3-(pyrimidin-2-yl)pyridin-2-yl]amino}methyl)phenol, CHLORIDE ION, Procaspase-6
Authors:	Fan, P, Zhao, Y, Renslo, A.R, Arkin, M.R.
Deposit date:	2022-11-18
Release date:	2023-12-13
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	A Comprehensive Empirical-Computational Study of Diverse Heteroarene Stacking Interactions Under Physiological Conditions To Be Published

8F9C

Compound 20 bound to procaspase-6
Descriptor:	5-fluoro-2-({[(3M)-3-(4H-1,2,4-triazol-3-yl)pyridin-2-yl]amino}methyl)phenol, Procaspase-6
Authors:	Fan, P, Zhao, Y, Renslo, A.R, Arkin, M.R.
Deposit date:	2022-11-23
Release date:	2023-12-13
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	A Comprehensive Empirical-Computational Study of Diverse Heteroarene Stacking Interactions Under Physiological Conditions To Be Published

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Total results:	339
Displayed results:	25
Sorted by:	Hit score (from highest)
Query:	PF00656