PDB: 121 resultsInfo pagesStatus searchChemie searchBIRD

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8TE1	Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, L(+)-TARTARIC ACID, ... Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer To Be Published
6U8X	Crystal structure of DNMT3B-DNMT3L in complex with CpApG DNA Descriptor: CpApG DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Song, J. Deposit date: 2019-09-06 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.95063877 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
8TE4	Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer To Be Published
6U91	Crystal structure of DNMT3B(Q772R)-DNMT3L in complex with CpGpT DNA Descriptor: CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Song, J. Deposit date: 2019-09-06 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.99998879 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms To Be Published
8TCI	Crystal structure of DNMT3C-DNMT3L in complex with CGG DNA Descriptor: (5'-D(P*CP*AP*TP*G)-R(P*(PYO))-D(P*GP*GP*TP*CP*TP*AP*AP*TP*TP*AP*GP*AP*CP*CP*GP*CP*AP*TP*G)-3'), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3C, ... Authors: Khudaverdyan, N, Song, J. Deposit date: 2023-07-01 Release date: 2024-08-14 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (3.19 Å) Cite: The structure of DNA methyltransferase DNMT3C reveals an activity-tuning mechanism for DNA methylation. J.Biol.Chem., 300, 2024
6U8P	Crystal structure of DNMT3B-DNMT3L in complex with CpGpA DNA Descriptor: CpGpA DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Song, J. Deposit date: 2019-09-05 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
6U90	Crystal structure of DNMT3B(N779A)-DNMT3L in complex with CpGpT DNA Descriptor: CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Song, J. Deposit date: 2019-09-06 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.00081754 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms To Be Published
6U8V	Crystal structure of DNMT3B-DNMT3L in complex with CpGpT DNA Descriptor: CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Zhang, Z.M, Song, J. Deposit date: 2019-09-06 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
6U8W	Crystal structure of DNMT3B(K777A)-DNMT3L in complex with CpGpT DNA Descriptor: CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Zhang, Z.M, Song, J. Deposit date: 2019-09-06 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.94891548 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
6KDL	Crystal structure of human DNMT3B-DNMT3L complex (I) Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-02 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.274 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6KDP	Crystal structure of human DNMT3B-DNMT3L complex (II) Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, FORMIC ACID, ... Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-02 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.93 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6KDB	Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpT site Descriptor: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-01 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.862 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6KDT	Crystal structure of human DNMT3B (Q772R)-DNMT3L complex Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, FORMIC ACID, ... Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-02 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.87 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6KDA	Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpG site Descriptor: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-01 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.909 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6MHT	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND DNA CONTAINING 4'-THIO-2'DEOXYCYTIDINE AT THE TARGET Descriptor: CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(4SC)P*GP*CP*AP*TP*GP*G)-3'), ... Authors: Cheng, X. Deposit date: 1998-08-05 Release date: 1998-08-12 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.05 Å) Cite: DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase. Nucleic Acids Res., 25, 1997
6W89	Structure of DNMT3A (R882H) in complex with CGA DNA Descriptor: CGA DNA (25-MER), CITRIC ACID, DNA (cytosine-5)-methyltransferase 3-like, ... Authors: Anteneh, H, Song, J. Deposit date: 2020-03-20 Release date: 2020-04-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.499 Å) Cite: Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020
6W8J	Structure of DNMT3A (R882H) in complex with CAG DNA Descriptor: CAG DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... Authors: Anteneh, H, Song, J. Deposit date: 2020-03-20 Release date: 2020-04-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.445 Å) Cite: Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020
6W8D	Structure of DNMT3A (R882H) in complex with CGT DNA Descriptor: CGT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... Authors: Anteneh, H, Song, J. Deposit date: 2020-03-20 Release date: 2020-04-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.598 Å) Cite: Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020
7L4C	Crystal structure of the DRM2-CTT DNA complex Descriptor: DNA (5'-D(*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*TP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*AP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... Authors: Fang, J, Song, J. Deposit date: 2020-12-18 Release date: 2021-08-04 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
7L4H	Crystal structure of the DRM2-CTG DNA complex Descriptor: DNA (5'-D(*AP*TP*TP*CP*CP*TP*AP*AP*TP*(C49)P*TP*GP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*CP*AP*GP*AP*TP*TP*AP*GP*GP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... Authors: Fang, J, Song, J. Deposit date: 2020-12-19 Release date: 2021-08-04 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
7L4K	Crystal structure of the DRM2-CCG DNA complex Descriptor: DNA (5'-D(*AP*TP*TP*CP*CP*TP*AP*AP*TP*(C49)P*CP*GP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*CP*GP*GP*AP*TP*TP*AP*GP*GP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... Authors: Fang, J, Song, J. Deposit date: 2020-12-19 Release date: 2021-08-04 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
7L4N	Crystal structure of the DRM2 (C397R)-CCG DNA complex Descriptor: DNA (5'-D(*AP*TP*TP*CP*CP*TP*AP*AP*TP*(C49)P*CP*GP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*CP*GP*GP*AP*TP*TP*AP*GP*GP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... Authors: Fang, J, Song, J. Deposit date: 2020-12-19 Release date: 2021-08-04 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.247 Å) Cite: Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
7L4M	Crystal structure of the DRM2-CCT DNA complex Descriptor: DNA (5'-D(*TP*AP*AP*AP*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*AP*AP*T)-3'), DNA (5'-D(P*AP*TP*TP*CP*CP*TP*CP*CP*TP*(C49)P*CP*TP*CP*CP*TP*TP*TP*A)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... Authors: Fang, J, Song, J. Deposit date: 2020-12-19 Release date: 2021-08-04 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.805 Å) Cite: Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
7L4F	Crystal structure of the DRM2-CAT DNA complex Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*AP*TP*TP*CP*CP*TP*CP*CP*TP*(C49)P*AP*TP*CP*CP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*GP*GP*AP*TP*GP*AP*GP*GP*AP*GP*GP*AP*AP*T)-3'), ... Authors: Fang, J, Song, J. Deposit date: 2020-12-19 Release date: 2021-08-04 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
2ZCJ	Ternary structure of the Glu119Gln M.HhaI, C5-Cytosine DNA methyltransferase, with unmodified DNA and AdoHcy Descriptor: DNA (5'-D(*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), DNA (5'-D(*DTP*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), Modification methylase HhaI, ... Authors: Shieh, F.K, Reich, N.O. Deposit date: 2007-11-09 Release date: 2007-12-04 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.75 Å) Cite: AdoMet-dependent Methyl-transfer: Glu(119) Is Essential for DNA C5-Cytosine Methyltransferase M.HhaI J.Mol.Biol., 373, 2007

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