PDB: 225158 resultsInfo pagesStatus searchChemie searchBIRD

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8QHV	275A Vipp1 helical tubes in the presence of EPL Descriptor: Membrane-associated protein Vipp1 Authors: Junglas, B, Sachse, C. Deposit date: 2023-09-11 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (7 Å) Cite: Structural basis for Vipp1 membrane binding: From rings and rods to carpets To Be Published
8QBR	Cryo-EM structure of Vipp1 helical filament with lattice 1 (Vipp1_L1) Descriptor: Membrane-associated protein Vipp1 Authors: Naskar, S, Low, H.H. Deposit date: 2023-08-25 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (3.74 Å) Cite: Mechanism for Vipp1 spiral formation, ring biogenesis and membrane repair. To Be Published
9B9Q	Cargo-loaded Myxococcus xanthus EncA encapsulin engineered pore mutant with T=3 icosahedral symmetry Descriptor: Encapsulin nanocompartment cargo protein EncC, Type 1 encapsulin shell protein EncA Authors: Andreas, M.P, Kwon, S, Giessen, T.W. Deposit date: 2024-04-03 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (3.14 Å) Cite: Pore Engineering as a General Strategy to Improve Protein-Based Enzyme Nanoreactor Performance. Acs Nano, 2024
9BD2	MAGE-A3 MHD crystal soaked with KL861 Descriptor: (furan-2-yl)[4-({(5P)-5-(1H-indazol-4-yl)-2-[3-(morpholin-4-yl)propoxy]phenyl}methyl)piperazin-1-yl]methanone, Melanoma-associated antigen 3 Authors: Butrin, A, Krone, M.W, Li, K, Bond, M.J, Linhares, B.M, Crews, C. Deposit date: 2024-04-10 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Development of Ligands and Degraders Targeting MAGE-A3. J.Am.Chem.Soc., 2024
9FJ4	Structure of ubiquitin bound to coiled coil-UIM form 1 Descriptor: 3-[1-(2-oxidanylideneethyl)-1,2,3-triazol-4-yl]propanal, GLU-GLN-GLU-ILE-GLU-GLU-LEU-GLU-ILE-GLU-ILE-ALA-ILE-LEU-LEU-SER-GLU-ILE-GLU-GLY, LYS-GLN-LYS-ILE-ALA-ALA-LEU-LYS-TYR-LYS-ILE-ALA-ALA-LEU-LYS-GLN-LYS-ILE-GLN, ... Authors: Paredes Vergara, P, Huang, D.T. Deposit date: 2024-05-30 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (1.54 Å) Cite: An engineered ubiquitin binding coiled coil peptide Chem Sci, 2024
9FJ3	Structure of ubiquitin bound of coiled-coil UIM form 2 Descriptor: 3-[1-(2-oxidanylideneethyl)-1,2,3-triazol-4-yl]propanal, GLU-GLN-GLU-ILE-GLU-GLU-LEU-GLU-ILE-GLU-ILE-ALA-ILE-LEU-LEU-SER-GLU-ILE-GLU-GLY, LYS-GLN-LYS-ILE-ALA-ALA-LEU-LYS-TYR-LYS-ILE-ALA-ALA-LEU-LYS-GLN-LYS-ILE, ... Authors: Paredes Vergara, P, Huang, D.T. Deposit date: 2024-05-30 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (1.4 Å) Cite: An engineered ubiquitin binding coiled coil peptide Chem Sci, 2024
8IC5	Respiratory complex CIII2, focus-refined of type I, PERK -/- mouse under cold temperature Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, CARDIOLIPIN, ... Authors: Shin, Y.-C, Liao, M. Deposit date: 2023-02-10 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Respiratory complex CIII2, focus-refined of type I, PERK -/- mouse under cold temperature To Be Published
8S7F	Crystal structure of Escherichia coli LpxH in complex with EBL-2805 Descriptor: MANGANESE (II) ION, N-[4-[4-[3,5-bis(chloranyl)phenyl]piperazin-1-yl]sulfonylphenyl]-2-[methyl(methylsulfonyl)amino]benzamide, UDP-2,3-diacylglucosamine hydrolase Authors: Sooriyaarachchi, S, Mowbray, S.L, Bergfors, T, Jones, T.A. Deposit date: 2024-03-01 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors. Eur.J.Med.Chem., 278, 2024
8ZYP	Cryo-EM Structure of E-4031-bound hERG Channel Descriptor: Potassium voltage-gated channel subfamily H member 2, ~{N}-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidin-4-yl]carbonylphenyl]methanesulfonamide Authors: Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. Deposit date: 2024-06-18 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (3.19 Å) Cite: Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors To Be Published
9B1G	Human urate transporter 1 URAT1 in complex with dotinurad Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 22 member 12, dotinurad Authors: Dai, Y, Lee, C.H. Deposit date: 2024-03-13 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Transport mechanism and structural pharmacology of human urate transporter URAT1. Cell Res., 2024
9B1H	Human urate transporter 1 URAT1 in complex with lesinurad Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 22 member 12, lesinurad Authors: Dai, Y, Lee, C.H. Deposit date: 2024-03-13 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Transport mechanism and structural pharmacology of human urate transporter URAT1. Cell Res., 2024
9B1I	Human urate transporter 1 URAT1 in complex with verinurad Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 22 member 12, verinurad Authors: Dai, Y, Lee, C.H. Deposit date: 2024-03-13 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Transport mechanism and structural pharmacology of human urate transporter URAT1. Cell Res., 2024
8WD7	Structural organization of the palisade layer in isolated vaccinia virus cores Descriptor: Core protein OPG136 Authors: Liu, Y, Qu, X, Duan, M, Shi, X, Liu, S, Shi, Y, Gao, G.F. Deposit date: 2023-09-14 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (10 Å) Cite: Cryo-ET reveals A10 protein as a major component of the poxvirus palisade layer To Be Published
8WDC	Structural organization of the palisade layer in intracellular mature vaccinia virions Descriptor: Core protein OPG136 Authors: Liu, Y, Qu, X, Duan, M, Shi, X, Liu, S, Shi, Y, Gao, G.F. Deposit date: 2023-09-14 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (7.7 Å) Cite: Cryo-ET reveals A10 protein as a major component of the poxvirus palisade layer To Be Published
8IB7	Respiratory complex CIII2, focus-refined of type IA, Wild type mouse under cold temperature Descriptor: 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, ... Authors: Shin, Y.-C, Liao, M. Deposit date: 2023-02-09 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Respiratory complex CIII2, focus-refined of type IA, Wild type mouse under cold temperature To Be Published
9CGN	Pikromycin Thioesterase with heptaketide adduct Descriptor: (2S,4R,5S,6S,8R,12R,13R)-5,13-dihydroxy-2,4,6,8,12-pentamethyl-3,9-dioxopentadecanal, Narbonolide/10-deoxymethynolide synthase PikA4, module 6 Authors: Smith, J.L, Choudhary, V. Deposit date: 2024-06-30 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation Acs Catalysis, 14, 2024
9CGL	Pikromycin Thioesterase Doubly Protected DAP Descriptor: 2-{[(1R)-1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethyl]sulfanyl}ethyl formate, Narbonolide/10-deoxymethynolide synthase PikA4, module 6 Authors: McCullough, T.M, Smith, J.L. Deposit date: 2024-06-29 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation Acs Catalysis, 14, 2024
9CIH	Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide across O4-methyl threofuranosyl thymidine in DNA template at extension stage Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), DNA (5'-D(*CP*AP*TP*GP*(A1A0L)P*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Tomar, R, Stone, M.P, Egli, M. Deposit date: 2024-07-03 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta. Biochemistry, 2024
9CJ9	Crystal structure of human polymerase eta with incoming dAMPnPP nucleotide opposite O4-methyl threofuranosyl thymidine in DNA template at insertion stage Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(TFT)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Tomar, R, Stone, M.P, Egli, M. Deposit date: 2024-07-05 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (2.98 Å) Cite: DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta. Biochemistry, 2024
9ENG	Structure of K.pneumoniae LpxH in complex with EBL-3218 Descriptor: MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase, ~{N}-[4-[4-[3,5-bis(chloranyl)phenyl]piperazin-1-yl]sulfonylphenyl]-3-(methylsulfonylamino)benzamide Authors: Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. Deposit date: 2024-03-12 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors. Eur.J.Med.Chem., 278, 2024
9C4M	Crystal Structure of A. baumannii GuaB dCBS with inhibitor G6 (3826) Descriptor: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase, N-[4-chloro-3-(morpholin-4-yl)phenyl]-N~2~-[3-(hydroxymethyl)quinolin-6-yl]-L-alaninamide Authors: Harris, S.F, Wu, P. Deposit date: 2024-06-04 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in Acinetobacter baumannii and Escherichia coli. J.Bacteriol., 2024
9CE4	Structure of CHK1 10-pt. mutant complex with LRRK2 indazole inhibitor compound 6 Descriptor: (1S,4r)-4-[(1P)-5-chloro-1-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-6-yl]-1-(oxetan-3-yl)piperidin-1-ium, 1,2-ETHANEDIOL, Serine/threonine-protein kinase Chk1 Authors: Palte, R.L, Zebisch, M, Henry, C, Barker, J.J. Deposit date: 2024-06-26 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors. J.Med.Chem., 2024
8CQW	Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B Descriptor: 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... Authors: Kolosova, O, Zgadzay, Y, Yusupov, M. Deposit date: 2023-03-07 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement To Be Published
8CRE	Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 Descriptor: 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... Authors: Kolosova, O, Zgadzay, Y, Yusupov, M. Deposit date: 2023-03-08 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (3 Å) Cite: Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement To Be Published
8IBC	Respiratory complex CIII2, focus-refined of type IB, Wild type mouse under cold temperature Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, CARDIOLIPIN, ... Authors: Shin, Y.-C, Liao, M. Deposit date: 2023-02-10 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Respiratory complex CIII2, focus-refined of type IB, Wild type mouse under cold temperature To Be Published

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