9CGN

Pikromycin Thioesterase with heptaketide adduct

This is a non-PDB format compatible entry.

Summary for 9CGN

• Entry DOI: 10.2210/pdb9cgn/pdb
• Descriptor: Narbonolide/10-deoxymethynolide synthase PikA4, module 6, (2S,4R,5S,6S,8R,12R,13R)-5,13-dihydroxy-2,4,6,8,12-pentamethyl-3,9-dioxopentadecanal (3 entities in total)
• Functional Keywords: thioesterase, unnatural amino acid, pks, natural products, hydrolase
• Biological source: Streptomyces venezuelae
• Total number of polymer chains: 2
• Total formula weight: 61220.98

Authors

Smith, J.L.,Choudhary, V. (deposition date: 2024-06-30, release date: 2024-09-18)

• Primary citation: McCullough, T.M.,Choudhary, V.,Akey, D.L.,Skiba, M.A.,Bernard, S.M.,Kittendorf, J.D.,Schmidt, J.J.,Sherman, D.H.,Smith, J.L.; Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation; Acs Catalysis, 14:-, 2024; DOI: 10.1021/acscatal.4c03637

Experimental method

X-RAY DIFFRACTION (2.8 Å)