9CIH

Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide across O4-methyl threofuranosyl thymidine in DNA template at extension stage

This is a non-PDB format compatible entry.

Summary for 9CIH

• Entry DOI: 10.2210/pdb9cih/pdb
• Descriptor: DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*(A1A0L)P*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), ... (7 entities in total)
• Functional Keywords: dna binding protein, dna polymerase, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 55497.79

Authors

Tomar, R.,Stone, M.P.,Egli, M. (deposition date: 2024-07-03, release date: 2024-09-18, Last modification date: 2024-09-25)

• Primary citation: Tomar, R.,Ghodke, P.P.,Patra, A.,Smyth, E.,Pontarelli, A.,Copp, W.,Guengerich, F.P.,Chaput, J.C.,Wilds, C.J.,Stone, M.P.,Egli, M.; DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.; Biochemistry, 2024; PubMed: 39259676; DOI: 10.1021/acs.biochem.4c00387

Experimental method

X-RAY DIFFRACTION (2.15 Å)