4G7T
| Rat Heme Oxygenase-1 in complex with Heme and CO with 1 hr Illumination: Laser on | Descriptor: | CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... | Authors: | Sugishima, M, Moffat, K, Noguchi, M. | Deposit date: | 2012-07-20 | Release date: | 2012-10-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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4G7P
| Rat Heme Oxygenase-1 in complex with Heme and CO with 1 hr Illumination at 100 K: Laser off | Descriptor: | CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... | Authors: | Sugishima, M, Moffat, K, Noguchi, M. | Deposit date: | 2012-07-20 | Release date: | 2012-10-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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4G7U
| Rat Heme Oxygenase-1 in complex with Heme and CO with 16 hr Illumination: Laser off | Descriptor: | CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... | Authors: | Sugishima, M, Moffat, K, Noguchi, M. | Deposit date: | 2012-07-20 | Release date: | 2012-10-31 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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3TGM
| X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 1-(1H-imidazol-1-yl)-4,4-diphenyl-2 butanone | Descriptor: | 1-(1H-imidazol-1-yl)-4,4-diphenylbutan-2-one, HEXANE-1,6-DIOL, Heme oxygenase 1, ... | Authors: | Rahman, M.N, Jia, Z. | Deposit date: | 2011-08-17 | Release date: | 2012-02-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A novel, "double-clamp" binding mode for human heme oxygenase-1 inhibition. Plos One, 7, 2012
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3MOO
| Crystal structure of the HmuO, heme oxygenase from Corynebacterium diphtheriae, in complex with azide-bound verdoheme | Descriptor: | 5-OXA-PROTOPORPHYRIN IX CONTAINING FE, AZIDE ION, Heme oxygenase, ... | Authors: | Omori, K, Matsui, T, Unno, M, Ikeda-Saito, M. | Deposit date: | 2010-04-22 | Release date: | 2011-03-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Enzymatic ring-opening mechanism of verdoheme by the heme oxygenase: a combined X-ray crystallography and QM/MM study. J.Am.Chem.Soc., 132, 2010
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3K4F
| X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 4-Phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone | Descriptor: | 4-phenyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one, HEXANE-1,6-DIOL, Heme oxygenase 1, ... | Authors: | Rahman, M.N, Jia, Z. | Deposit date: | 2009-10-05 | Release date: | 2009-12-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Heme Oxygenase Inhibition by 2-Oxy-substituted 1-Azolyl-4-phenylbutanes: Effect of Variation of the Azole Moiety. X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 4-Phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone. Chem.Biol.Drug Des., 75, 2010
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3I9T
| Crystal structure of the rat heme oxygenase (HO-1) in complex with heme binding dithiothreitol (DTT) | Descriptor: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Matsui, T, Unno, M, Ikeda-Saito, M. | Deposit date: | 2009-07-13 | Release date: | 2010-05-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Dioxygen activation for the self-degradation of heme: reaction mechanism and regulation of heme oxygenase. Inorg.Chem., 49, 2010
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3I9U
| Crystal structure of the rat heme oxygenase (HO-1) in complex with heme binding dithioerythritol (DTE) | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Matsui, T, Unno, M, Ikeda-Saito, M. | Deposit date: | 2009-07-13 | Release date: | 2010-05-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Dioxygen activation for the self-degradation of heme: reaction mechanism and regulation of heme oxygenase. Inorg.Chem., 49, 2010
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3I8R
| Crystal structure of the heme oxygenase from Corynebacterium diphtheriae (HmuO) in complex with heme binding ditiothreitol (DTT) | Descriptor: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Heme oxygenase, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Matsui, T, Unno, M, Ikeda-Saito, M. | Deposit date: | 2009-07-10 | Release date: | 2010-05-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Dioxygen activation for the self-degradation of heme: reaction mechanism and regulation of heme oxygenase. Inorg.Chem., 49, 2010
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3HOK
| X-ray Crystal Structure of Human Heme Oxygenase-1 with (2R, 4S)-2-[2-(4-Chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: A Novel, Inducible Binding Mode | Descriptor: | 2-({[(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)-5-(trifluoromethyl)pyridine, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Rahman, M.N, Jia, Z. | Deposit date: | 2009-06-02 | Release date: | 2009-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | X-ray crystal structure of human heme oxygenase-1 with (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: a novel, inducible binding mode. J.Med.Chem., 52, 2009
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2ZVU
| Crystal structure of rat heme oxygenase-1 in complex with ferrous verdoheme | Descriptor: | 5-OXA-PROTOPORPHYRIN IX CONTAINING FE, FORMIC ACID, Heme oxygenase 1 | Authors: | Sato, H, Sugishima, M, Fukuyama, K, Noguchi, M. | Deposit date: | 2008-11-21 | Release date: | 2009-02-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of rat haem oxygenase-1 in complex with ferrous verdohaem: presence of a hydrogen-bond network on the distal side Biochem.J., 419, 2009
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3CZY
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2RGZ
| Ensemble refinement of the protein crystal structure of human heme oxygenase-2 C127A (HO-2) with bound heme | Descriptor: | Heme oxygenase 2, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Bianchetti, C.M, Bingman, C.A, Bitto, E, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2007-10-05 | Release date: | 2007-10-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2. J.Biol.Chem., 282, 2007
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2QPP
| Crystal structure of human heme oxygenase-2 C127A (HO-2) with bound heme | Descriptor: | Heme oxygenase 2, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Bianchetti, C.M, Bingman, C.A, Bitto, E, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2007-07-24 | Release date: | 2007-08-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2. J.Biol.Chem., 282, 2007
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2Z68
| Crystal Structure Of An Artificial Metalloprotein: Cr[N-salicylidene-4-amino-3-hydroxyhydrocinnamic acid]/Wild Type Heme oxygenase | Descriptor: | Heme oxygenase, SODIUM ION, SULFATE ION, ... | Authors: | Yokoi, N, Unno, M, Ueno, T, Ikeda-Saito, M, Watanabe, Y. | Deposit date: | 2007-07-24 | Release date: | 2007-08-28 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Ligand design for the improvement of stability of metal complex.protein hybrids. Chem.Commun.(Camb.), 2008
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2Q32
| Crystal structure of human heme oxygenase-2 C127A (HO-2) | Descriptor: | Heme oxygenase 2, OXTOXYNOL-10 | Authors: | Bianchetti, C.M, Bingman, C.A, Bitto, E, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2007-05-29 | Release date: | 2007-06-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2. J.Biol.Chem., 282, 2007
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2E7E
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2DY5
| Crystal structure of rat heme oxygenase-1 in complex with heme and 2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane | Descriptor: | 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE, CHLORIDE ION, Heme oxygenase 1, ... | Authors: | Sugishima, M, Takahashi, H, Fukuyama, K. | Deposit date: | 2006-09-06 | Release date: | 2007-05-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase Biochemistry, 46, 2007
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1WZF
| Crystal Structure Of An Artificial Metalloprotein: Fe(10-COOH-Salophen)/Wild Type Heme oxygenase | Descriptor: | GLYCEROL, Heme oxygenase, SULFATE ION, ... | Authors: | Unno, M, Yokoi, N, Ueno, T, Watanabe, Y, Ikeda-Saito, M. | Deposit date: | 2005-03-04 | Release date: | 2006-02-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Design of metal cofactors activated by a protein-protein electron transfer system. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1WZD
| Crystal Structure Of An Artificial Metalloprotein: Fe(10-CH2CH2COOH-Salophen)/Wild Type Heme oxygenase | Descriptor: | GLYCEROL, Heme oxygenase, SULFATE ION, ... | Authors: | Unno, M, Yokoi, N, Ueno, T, Watanabe, Y, Ikeda-Saito, M. | Deposit date: | 2005-03-04 | Release date: | 2006-02-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Design of metal cofactors activated by a protein-protein electron transfer system. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1WZG
| Crystal Structure Of An Artificial Metalloprotein: Fe(Salophen)/Wild Type Heme oxygenase | Descriptor: | 2,2'-[1,2-PHENYLENEBIS(NITRILOMETHYLIDYNE)]BIS[PHENOLATO]](2-)-N,N',O,O']-IRON, GLYCEROL, Heme oxygenase, ... | Authors: | Unno, M, Yokoi, N, Ueno, T, Watanabe, Y, Ikeda-Saito, M. | Deposit date: | 2005-03-04 | Release date: | 2006-02-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Design of metal cofactors activated by a protein-protein electron transfer system. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1XK2
| NADPH- and Ascorbate-Supported Heme Oxygenase Reactions are Distinct. Regiospecificity of Heme Cleavage by the R183E Mutant | Descriptor: | Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Wang, J, Lad, L, Poulos, T.L, Ortiz de montellano, P.R. | Deposit date: | 2004-09-26 | Release date: | 2004-11-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Regiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant. J.Biol.Chem., 280, 2005
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1XK0
| Crystal Structures of the G139A, G139A-NO and G143H Mutants of Human Heme Oxygenase-1 | Descriptor: | Heme oxygenase 1, NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Lad, L, Koshkin, A, Ortiz de Montellano, P.R, Poulos, T.L. | Deposit date: | 2004-09-26 | Release date: | 2005-12-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Crystal structures of the G139A, G139A-NO and G143H mutants of human heme oxygenase-1. A finely tuned hydrogen-bonding network controls oxygenase versus peroxidase activity. J.Biol.Inorg.Chem., 10, 2005
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1XK3
| NADPH- and Ascorbate-Supported Heme Oxygenase Reactions are Distinct. Regiospecificity of Heme Cleavage by the R183E Mutant | Descriptor: | Heme oxygenase 1, NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Wang, J, Lad, L, Poulos, T.L, Ortiz de montellano, P.R. | Deposit date: | 2004-09-26 | Release date: | 2004-11-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Regiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant. J.Biol.Chem., 280, 2005
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1XK1
| Crystal Structures of the G139A, G139A-NO and G143H Mutants of Human Heme Oxygenase-1 | Descriptor: | Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Lad, L, Ortiz de Montellano, P.R, Poulos, T.L. | Deposit date: | 2004-09-26 | Release date: | 2005-12-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Crystal structures of the G139A, G139A-NO and G143H mutants of human heme oxygenase-1. A finely tuned hydrogen-bonding network controls oxygenase versus peroxidase activity. J.Biol.Inorg.Chem., 10, 2005
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